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Mediterranean diet, retinopathy, nephropathy, and microvascular diabetes complications: a post hoc analysis of a randomized trial.

OBJECTIVE: To date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephr... Full description

Main Author: Díaz‑López, Andrés
Other Authors: Babio, Nancy , Martínez - González, Miguel A. , Dolores, Corella , Amor, Antonio J. , Fitó Colomer, Montserrat , Estruch, Ramón , Arós, Fernando , Gómez - Gracia, Enrique , Fiol, Miquel , Lapetra, José , Serra - Majem, Luis , Basora, J. , Basterra - Gortari, F. Javier , Zanon - Moreno, Vicente , Muñoz, Miguel Ángel , Salas - Salvadó, Jordi , Predimed Investigators
Format: Electronic Article Electronic Article
Language: English
Subjects:
Created: 2015
ID: ISSN: 0149-5992 ; DOI: 10.2337/dc15-1117
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recordid: upf10230/25963
title: Mediterranean diet, retinopathy, nephropathy, and microvascular diabetes complications: a post hoc analysis of a randomized trial.
format: Article
creator:
  • Díaz‑López, Andrés
  • Babio, Nancy
  • Martínez - González, Miguel A.
  • Dolores, Corella
  • Amor, Antonio J.
  • Fitó Colomer, Montserrat
  • Estruch, Ramón
  • Arós, Fernando
  • Gómez - Gracia, Enrique
  • Fiol, Miquel
  • Lapetra, José
  • Serra - Majem, Luis
  • Basora, J.
  • Basterra - Gortari, F. Javier
  • Zanon - Moreno, Vicente
  • Muñoz, Miguel Ángel
  • Salas - Salvadó, Jordi
  • Predimed Investigators
subjects:
  • Dieta -- Mediterrània, Regió de la
  • Retinopatia diabètica
ispartof:
description: OBJECTIVE: To date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat control diet. RESEARCH DESIGN AND METHODS: This was a post hoc analysis of a cohort of patients with type 2 diabetes participating in the PREvención con DIeta MEDiterránea (PREDIMED) study, a multicenter randomized nutritional intervention trial conducted in a population at high cardiovascular risk. Individuals with type 2 diabetes who were free of microvascular complications at enrollment (n = 3,614, aged 55-80 years) were randomly assigned to one of three dietary interventions: MedDiet supplemented with extravirgin olive oil (MedDiet+EVOO), MedDiet supplemented with mixed nuts (MedDiet+Nuts), or a low-fat control diet. Two independent outcomes were considered: new onset of diabetic retinopathy and nephropathy. Hazard ratios (HRs) were calculated using multivariable-adjusted Cox regression./nRESULTS: During a median follow-up of 6.0 years, we identified 74 new cases of retinopathy and 168 of nephropathy. Compared with the control diet, multivariable-adjusted HRs for diabetic retinopathy were 0.56 (95% CI 0.32-0.97) for the MedDiet+EVOO and 0.63 (0.35-1.11) for the MedDiet+Nuts. No between-group differences were found for nephropathy. When the yearly updated information on adherence to the MedDiet was considered, the HR for retinopathy in the highest versus the lowest quintile was 0.34 (0.13-0.89; P = 0.001 for trend). No significant associations were found for nephropathy. CONCLUSIONS: A MedDiet enriched with EVOO may protect against diabetic retinopathy but not diabetic nephropathy.
language: eng
source:
identifier: ISSN: 0149-5992 ; DOI: 10.2337/dc15-1117
fulltext: fulltext_linktorsrc
issn:
  • 01495992
  • 0149-5992
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titleMediterranean diet, retinopathy, nephropathy, and microvascular diabetes complications: a post hoc analysis of a randomized trial.
creatorDíaz‑López, Andrés ; Babio, Nancy ; Martínez - González, Miguel A. ; Dolores, Corella ; Amor, Antonio J. ; Fitó Colomer, Montserrat ; Estruch, Ramón ; Arós, Fernando ; Gómez - Gracia, Enrique ; Fiol, Miquel ; Lapetra, José ; Serra - Majem, Luis ; Basora, J. ; Basterra - Gortari, F. Javier ; Zanon - Moreno, Vicente ; Muñoz, Miguel Ángel ; Salas - Salvadó, Jordi ; Predimed Investigators
creationdate2015
identifier ISSN: 0149-5992 ; DOI: 10.2337/dc15-1117
subjectDieta -- Mediterrània, Regió de la ; Retinopatia diabètica
descriptionOBJECTIVE: To date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat control diet. RESEARCH DESIGN AND METHODS: This was a post hoc analysis of a cohort of patients with type 2 diabetes participating in the PREvención con DIeta MEDiterránea (PREDIMED) study, a multicenter randomized nutritional intervention trial conducted in a population at high cardiovascular risk. Individuals with type 2 diabetes who were free of microvascular complications at enrollment (n = 3,614, aged 55-80 years) were randomly assigned to one of three dietary interventions: MedDiet supplemented with extravirgin olive oil (MedDiet+EVOO), MedDiet supplemented with mixed nuts (MedDiet+Nuts), or a low-fat control diet. Two independent outcomes were considered: new onset of diabetic retinopathy and nephropathy. Hazard ratios (HRs) were calculated using multivariable-adjusted Cox regression./nRESULTS: During a median follow-up of 6.0 years, we identified 74 new cases of retinopathy and 168 of nephropathy. Compared with the control diet, multivariable-adjusted HRs for diabetic retinopathy were 0.56 (95% CI 0.32-0.97) for the MedDiet+EVOO and 0.63 (0.35-1.11) for the MedDiet+Nuts. No between-group differences were found for nephropathy. When the yearly updated information on adherence to the MedDiet was considered, the HR for retinopathy in the highest versus the lowest quintile was 0.34 (0.13-0.89; P = 0.001 for trend). No significant associations were found for nephropathy. CONCLUSIONS: A MedDiet enriched with EVOO may protect against diabetic retinopathy but not diabetic nephropathy.
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7Arós, Fernando
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9Fiol, Miquel
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16Salas - Salvadó, Jordi
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titleMediterranean diet, retinopathy, nephropathy, and microvascular diabetes complications: a post hoc analysis of a randomized trial.
descriptionOBJECTIVE: To date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat control diet. RESEARCH DESIGN AND METHODS: This was a post hoc analysis of a cohort of patients with type 2 diabetes participating in the PREvención con DIeta MEDiterránea (PREDIMED) study, a multicenter randomized nutritional intervention trial conducted in a population at high cardiovascular risk. Individuals with type 2 diabetes who were free of microvascular complications at enrollment (n = 3,614, aged 55-80 years) were randomly assigned to one of three dietary interventions: MedDiet supplemented with extravirgin olive oil (MedDiet+EVOO), MedDiet supplemented with mixed nuts (MedDiet+Nuts), or a low-fat control diet. Two independent outcomes were considered: new onset of diabetic retinopathy and nephropathy. Hazard ratios (HRs) were calculated using multivariable-adjusted Cox regression./nRESULTS: During a median follow-up of 6.0 years, we identified 74 new cases of retinopathy and 168 of nephropathy. Compared with the control diet, multivariable-adjusted HRs for diabetic retinopathy were 0.56 (95% CI 0.32-0.97) for the MedDiet+EVOO and 0.63 (0.35-1.11) for the MedDiet+Nuts. No between-group differences were found for nephropathy. When the yearly updated information on adherence to the MedDiet was considered, the HR for retinopathy in the highest versus the lowest quintile was 0.34 (0.13-0.89; P = 0.001 for trend). No significant associations were found for nephropathy. CONCLUSIONS: A MedDiet enriched with EVOO may protect against diabetic retinopathy but not diabetic nephropathy.
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titleMediterranean diet, retinopathy, nephropathy, and microvascular diabetes complications: a post hoc analysis of a randomized trial.
authorDíaz‑López, Andrés ; Babio, Nancy ; Martínez - González, Miguel A. ; Dolores, Corella ; Amor, Antonio J. ; Fitó Colomer, Montserrat ; Estruch, Ramón ; Arós, Fernando ; Gómez - Gracia, Enrique ; Fiol, Miquel ; Lapetra, José ; Serra - Majem, Luis ; Basora, J. ; Basterra - Gortari, F. Javier ; Zanon - Moreno, Vicente ; Muñoz, Miguel Ángel ; Salas - Salvadó, Jordi ; Predimed Investigators
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7Arós, Fernando
8Gómez - Gracia, Enrique
9Fiol, Miquel
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11Serra - Majem, Luis
12Basora, J.
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6Estruch, Ramón
7Arós, Fernando
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12Basora, J.
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atitleMediterranean diet, retinopathy, nephropathy, and microvascular diabetes complications: a post hoc analysis of a randomized trial.
date2015
risdate2015
issn0149-5992
formatjournal
abstractOBJECTIVE: To date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat control diet. RESEARCH DESIGN AND METHODS: This was a post hoc analysis of a cohort of patients with type 2 diabetes participating in the PREvención con DIeta MEDiterránea (PREDIMED) study, a multicenter randomized nutritional intervention trial conducted in a population at high cardiovascular risk. Individuals with type 2 diabetes who were free of microvascular complications at enrollment (n = 3,614, aged 55-80 years) were randomly assigned to one of three dietary interventions: MedDiet supplemented with extravirgin olive oil (MedDiet+EVOO), MedDiet supplemented with mixed nuts (MedDiet+Nuts), or a low-fat control diet. Two independent outcomes were considered: new onset of diabetic retinopathy and nephropathy. Hazard ratios (HRs) were calculated using multivariable-adjusted Cox regression./nRESULTS: During a median follow-up of 6.0 years, we identified 74 new cases of retinopathy and 168 of nephropathy. Compared with the control diet, multivariable-adjusted HRs for diabetic retinopathy were 0.56 (95% CI 0.32-0.97) for the MedDiet+EVOO and 0.63 (0.35-1.11) for the MedDiet+Nuts. No between-group differences were found for nephropathy. When the yearly updated information on adherence to the MedDiet was considered, the HR for retinopathy in the highest versus the lowest quintile was 0.34 (0.13-0.89; P = 0.001 for trend). No significant associations were found for nephropathy. CONCLUSIONS: A MedDiet enriched with EVOO may protect against diabetic retinopathy but not diabetic nephropathy.
pubAmerican Diabetes Association
doi10.2337/dc15-1117
pages2134-2141
volume38
issue11
eissn19355548
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