schliessen

Filtern

 

Bibliotheken

Mediterranean diet and age-related cognitive decline: a randomized clinical trial

IMPORTANCE: Oxidative stress and vascular impairment are believed to partly mediate age-related cognitive decline, a strong risk factor for development of dementia. Epidemiologic studies suggest that a Mediterranean diet, an antioxidant-rich cardioprotective dietary pattern, delays cognitive decline... Full description

Main Author: Valls Pedret, Cinta
Other Authors: Sala Vila, Aleix , Serra Mir, Mercè , Corella, Dolores , Torre Fornell, Rafael De La , Martínez - González, Miguel A. , Martínez Lapiscina, Elena H. , Fitó Colomer, Montserrat , Pérez Heras, Ana , Salas - Salvadó, Jordi , Estruch, Ramón , Ros, Emilio
Format: Electronic Article Electronic Article
Language: English
Subjects:
Created: 2015
ID: ISSN: 2168-6106 ; DOI: 10.1001/jamainternmed.2015.1668
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: upf10230/26167
title: Mediterranean diet and age-related cognitive decline: a randomized clinical trial
format: Article
creator:
  • Valls Pedret, Cinta
  • Sala Vila, Aleix
  • Serra Mir, Mercè
  • Corella, Dolores
  • Torre Fornell, Rafael De La
  • Martínez - González, Miguel A.
  • Martínez Lapiscina, Elena H.
  • Fitó Colomer, Montserrat
  • Pérez Heras, Ana
  • Salas - Salvadó, Jordi
  • Estruch, Ramón
  • Ros, Emilio
subjects:
  • Trastorns de la cognició
  • Dieta -- Mediterrània, Regió de la
  • Tests neuropsicològics
ispartof:
description: IMPORTANCE: Oxidative stress and vascular impairment are believed to partly mediate age-related cognitive decline, a strong risk factor for development of dementia. Epidemiologic studies suggest that a Mediterranean diet, an antioxidant-rich cardioprotective dietary pattern, delays cognitive decline, but clinical trial evidence is lacking. OBJECTIVE: To investigate whether a Mediterranean diet supplemented with antioxidant-rich foods influences cognitive function compared with a control diet. DESIGN, SETTING, AND PARTICIPANTS: Parallel-group randomized clinical trial of 447 cognitively healthy volunteers from Barcelona, Spain (233 women [52.1%]; mean age, 66.9 years), at high cardiovascular risk were enrolled into the Prevención con Dieta Mediterránea nutrition intervention trial from October 1, 2003, through December 31, 2009. All patients underwent neuropsychological assessment at inclusion and were offered retesting at the end of the study. INTERVENTIONS: Participants were randomly assigned to a Mediterranean diet supplemented with extravirgin olive oil (1 L/wk), a Mediterranean diet supplemented with mixed nuts (30 g/d), or a control diet (advice to reduce dietary fat). MAIN OUTCOMES AND MEASURES: Rates of cognitive change over time based on a neuropsychological test battery: Mini-Mental State Examination, Rey Auditory Verbal Learning Test (RAVLT), Animals Semantic Fluency, Digit Span subtest from the Wechsler Adult Intelligence Scale, Verbal Paired Associates from the Wechsler Memory Scale, and the Color Trail Test. We used mean z scores of change in each test to construct 3 cognitive composites: memory, frontal (attention and executive function), and global. RESULTS: Follow-up cognitive tests were available in 334 participants after intervention (median, 4.1 years). In multivariate analyses adjusted for confounders, participants allocated to a Mediterranean diet plus olive oil scored better on the RAVLT (P = .049) and Color Trail Test part 2 (P = .04) compared with controls; no between-group differences were observed for the other cognitive tests. Similarly adjusted cognitive composites (mean z scores with 95% CIs) for changes above baseline of the memory composite were 0.04 (-0.09 to 0.18) for the Mediterranean diet plus olive oil, 0.09 (-0.05 to 0.23; P = .04 vs controls) for the Mediterranean diet plus nuts, and -0.17 (-0.32 to -0.01) for the control diet. Respective changes from baseline of the frontal cognition composite were 0.23 (0.03 to 0.43;
language: eng
source:
identifier: ISSN: 2168-6106 ; DOI: 10.1001/jamainternmed.2015.1668
fulltext: fulltext_linktorsrc
issn:
  • 21686106
  • 2168-6106
url: Link


@attributes
ID1126137740
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10230/26167
sourceidupf
recordidTN_upf10230/26167
sourcesystemPC
pqid1695772564
galeid428966113
display
typearticle
titleMediterranean diet and age-related cognitive decline: a randomized clinical trial
creatorValls Pedret, Cinta ; Sala Vila, Aleix ; Serra Mir, Mercè ; Corella, Dolores ; Torre Fornell, Rafael De La ; Martínez - González, Miguel A. ; Martínez Lapiscina, Elena H. ; Fitó Colomer, Montserrat ; Pérez Heras, Ana ; Salas - Salvadó, Jordi ; Estruch, Ramón ; Ros, Emilio
creationdate2015
identifier ISSN: 2168-6106 ; DOI: 10.1001/jamainternmed.2015.1668
subjectTrastorns de la cognició ; Dieta -- Mediterrània, Regió de la ; Tests neuropsicològics
descriptionIMPORTANCE: Oxidative stress and vascular impairment are believed to partly mediate age-related cognitive decline, a strong risk factor for development of dementia. Epidemiologic studies suggest that a Mediterranean diet, an antioxidant-rich cardioprotective dietary pattern, delays cognitive decline, but clinical trial evidence is lacking. OBJECTIVE: To investigate whether a Mediterranean diet supplemented with antioxidant-rich foods influences cognitive function compared with a control diet. DESIGN, SETTING, AND PARTICIPANTS: Parallel-group randomized clinical trial of 447 cognitively healthy volunteers from Barcelona, Spain (233 women [52.1%]; mean age, 66.9 years), at high cardiovascular risk were enrolled into the Prevención con Dieta Mediterránea nutrition intervention trial from October 1, 2003, through December 31, 2009. All patients underwent neuropsychological assessment at inclusion and were offered retesting at the end of the study. INTERVENTIONS: Participants were randomly assigned to a Mediterranean diet supplemented with extravirgin olive oil (1 L/wk), a Mediterranean diet supplemented with mixed nuts (30 g/d), or a control diet (advice to reduce dietary fat). MAIN OUTCOMES AND MEASURES: Rates of cognitive change over time based on a neuropsychological test battery: Mini-Mental State Examination, Rey Auditory Verbal Learning Test (RAVLT), Animals Semantic Fluency, Digit Span subtest from the Wechsler Adult Intelligence Scale, Verbal Paired Associates from the Wechsler Memory Scale, and the Color Trail Test. We used mean z scores of change in each test to construct 3 cognitive composites: memory, frontal (attention and executive function), and global. RESULTS: Follow-up cognitive tests were available in 334 participants after intervention (median, 4.1 years). In multivariate analyses adjusted for confounders, participants allocated to a Mediterranean diet plus olive oil scored better on the RAVLT (P = .049) and Color Trail Test part 2 (P = .04) compared with controls; no between-group differences were observed for the other cognitive tests. Similarly adjusted cognitive composites (mean z scores with 95% CIs) for changes above baseline of the memory composite were 0.04 (-0.09 to 0.18) for the Mediterranean diet plus olive oil, 0.09 (-0.05 to 0.23; P = .04 vs controls) for the Mediterranean diet plus nuts, and -0.17 (-0.32 to -0.01) for the control diet. Respective changes from baseline of the frontal cognition composite were 0.23 (0.03 to 0.43; P = .003 vs controls), 0.03 (-0.25 to 0.31), and -0.33 (-0.57 to -0.09). Changes from baseline of the global cognition composite were 0.05 (-0.11 to 0.21; P = .005 vs controls) for the Mediterranean diet plus olive oil, -0.05 (-0.27 to 0.18) for the Mediterranean diet plus nuts, and -0.38 (-0.57 to -0.18) for the control diet. All cognitive composites significantly (P < .05) decreased from baseline in controls. CONCLUSIONS AND RELEVANCE: In an older population, a Mediterranean diet supplemented with olive oil or nuts is associated with improved cognitive function. TRIAL REGISTRATION: isrctn.org Identifier: ISRCTN35739639.
languageeng
source
version9
oafree_for_read
lds50peer_reviewed
links
openurl$$Topenurl_article
linktorsrc$$Uhttp://hdl.handle.net/10230/26167$$EView_full_text_in_UPF
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Valls Pedret, Cinta
1Sala Vila, Aleix
2Serra Mir, Mercè
3Corella, Dolores
4Torre Fornell, Rafael De La
5Martínez - González, Miguel A.
6Martínez Lapiscina, Elena H.
7Fitó Colomer, Montserrat
8Pérez Heras, Ana
9Salas - Salvadó, Jordi
10Estruch, Ramón
11Ros, Emilio
titleMediterranean diet and age-related cognitive decline: a randomized clinical trial
descriptionIMPORTANCE: Oxidative stress and vascular impairment are believed to partly mediate age-related cognitive decline, a strong risk factor for development of dementia. Epidemiologic studies suggest that a Mediterranean diet, an antioxidant-rich cardioprotective dietary pattern, delays cognitive decline, but clinical trial evidence is lacking. OBJECTIVE: To investigate whether a Mediterranean diet supplemented with antioxidant-rich foods influences cognitive function compared with a control diet. DESIGN, SETTING, AND PARTICIPANTS: Parallel-group randomized clinical trial of 447 cognitively healthy volunteers from Barcelona, Spain (233 women [52.1%]; mean age, 66.9 years), at high cardiovascular risk were enrolled into the Prevención con Dieta Mediterránea nutrition intervention trial from October 1, 2003, through December 31, 2009. All patients underwent neuropsychological assessment at inclusion and were offered retesting at the end of the study. INTERVENTIONS: Participants were randomly assigned to a Mediterranean diet supplemented with extravirgin olive oil (1 L/wk), a Mediterranean diet supplemented with mixed nuts (30 g/d), or a control diet (advice to reduce dietary fat). MAIN OUTCOMES AND MEASURES: Rates of cognitive change over time based on a neuropsychological test battery: Mini-Mental State Examination, Rey Auditory Verbal Learning Test (RAVLT), Animals Semantic Fluency, Digit Span subtest from the Wechsler Adult Intelligence Scale, Verbal Paired Associates from the Wechsler Memory Scale, and the Color Trail Test. We used mean z scores of change in each test to construct 3 cognitive composites: memory, frontal (attention and executive function), and global. RESULTS: Follow-up cognitive tests were available in 334 participants after intervention (median, 4.1 years). In multivariate analyses adjusted for confounders, participants allocated to a Mediterranean diet plus olive oil scored better on the RAVLT (P = .049) and Color Trail Test part 2 (P = .04) compared with controls; no between-group differences were observed for the other cognitive tests. Similarly adjusted cognitive composites (mean z scores with 95% CIs) for changes above baseline of the memory composite were 0.04 (-0.09 to 0.18) for the Mediterranean diet plus olive oil, 0.09 (-0.05 to 0.23; P = .04 vs controls) for the Mediterranean diet plus nuts, and -0.17 (-0.32 to -0.01) for the control diet. Respective changes from baseline of the frontal cognition composite were 0.23 (0.03 to 0.43; P = .003 vs controls), 0.03 (-0.25 to 0.31), and -0.33 (-0.57 to -0.09). Changes from baseline of the global cognition composite were 0.05 (-0.11 to 0.21; P = .005 vs controls) for the Mediterranean diet plus olive oil, -0.05 (-0.27 to 0.18) for the Mediterranean diet plus nuts, and -0.38 (-0.57 to -0.18) for the control diet. All cognitive composites significantly (P < .05) decreased from baseline in controls. CONCLUSIONS AND RELEVANCE: In an older population, a Mediterranean diet supplemented with olive oil or nuts is associated with improved cognitive function. TRIAL REGISTRATION: isrctn.org Identifier: ISRCTN35739639.
subject
0Trastorns de la cognició
1Dieta -- Mediterrània, Regió de la
2Tests neuropsicològics
general
0English
1American Medical Association
210.1001/jamainternmed.2015.1668
3Repositori Digital de la UPF (Universitat Pompeu Fabra)
sourceidupf
recordidupf10230/26167
issn
021686106
12168-6106
rsrctypearticle
creationdate2015
searchscopeupf
scopeupf
lsr30VSR-Enriched:[issue, date, pqid, vol, galeid, pages, eissn]
sort
titleMediterranean diet and age-related cognitive decline: a randomized clinical trial
authorValls Pedret, Cinta ; Sala Vila, Aleix ; Serra Mir, Mercè ; Corella, Dolores ; Torre Fornell, Rafael De La ; Martínez - González, Miguel A. ; Martínez Lapiscina, Elena H. ; Fitó Colomer, Montserrat ; Pérez Heras, Ana ; Salas - Salvadó, Jordi ; Estruch, Ramón ; Ros, Emilio
creationdate20150000
facets
frbrgroupid7343113502060763902
frbrtype5
languageeng
creationdate2015
topic
0Trastorns de la cognició
1Dieta -- Mediterrània, Regió de la
2Tests neuropsicològics
collectionRepositori Digital de la UPF (Universitat Pompeu Fabra)
prefilterarticles
rsrctypearticles
creatorcontrib
0Valls Pedret, Cinta
1Sala Vila, Aleix
2Serra Mir, Mercè
3Corella, Dolores
4Torre Fornell, Rafael De La
5Martínez - González, Miguel A.
6Martínez Lapiscina, Elena H.
7Fitó Colomer, Montserrat
8Pérez Heras, Ana
9Salas - Salvadó, Jordi
10Estruch, Ramón
11Ros, Emilio
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext_linktorsrc
addata
aulast
0Valls Pedret
1Sala Vila
2Serra Mir
3Corella
4Torre Fornell
5Martínez-González
6Martínez Lapiscina
7Fitó Colomer
8Pérez Heras
9Salas-Salvadó
10Estruch
11Ros
aufirst
0Cinta
1Aleix
2Mercè
3Dolores
4Rafael de la
5Miguel A.
6Elena H.
7Montserrat
8Ana
9Jordi
10Ramón
11Emilio
au
0Valls Pedret, Cinta
1Sala Vila, Aleix
2Serra Mir, Mercè
3Corella, Dolores
4Torre Fornell, Rafael De La
5Martínez - González, Miguel A.
6Martínez Lapiscina, Elena H.
7Fitó Colomer, Montserrat
8Pérez Heras, Ana
9Salas - Salvadó, Jordi
10Estruch, Ramón
11Ros, Emilio
atitleMediterranean diet and age-related cognitive decline: a randomized clinical trial
risdate2015
issn2168-6106
formatjournal
genrearticle
ristypeJOUR
abstractIMPORTANCE: Oxidative stress and vascular impairment are believed to partly mediate age-related cognitive decline, a strong risk factor for development of dementia. Epidemiologic studies suggest that a Mediterranean diet, an antioxidant-rich cardioprotective dietary pattern, delays cognitive decline, but clinical trial evidence is lacking. OBJECTIVE: To investigate whether a Mediterranean diet supplemented with antioxidant-rich foods influences cognitive function compared with a control diet. DESIGN, SETTING, AND PARTICIPANTS: Parallel-group randomized clinical trial of 447 cognitively healthy volunteers from Barcelona, Spain (233 women [52.1%]; mean age, 66.9 years), at high cardiovascular risk were enrolled into the Prevención con Dieta Mediterránea nutrition intervention trial from October 1, 2003, through December 31, 2009. All patients underwent neuropsychological assessment at inclusion and were offered retesting at the end of the study. INTERVENTIONS: Participants were randomly assigned to a Mediterranean diet supplemented with extravirgin olive oil (1 L/wk), a Mediterranean diet supplemented with mixed nuts (30 g/d), or a control diet (advice to reduce dietary fat). MAIN OUTCOMES AND MEASURES: Rates of cognitive change over time based on a neuropsychological test battery: Mini-Mental State Examination, Rey Auditory Verbal Learning Test (RAVLT), Animals Semantic Fluency, Digit Span subtest from the Wechsler Adult Intelligence Scale, Verbal Paired Associates from the Wechsler Memory Scale, and the Color Trail Test. We used mean z scores of change in each test to construct 3 cognitive composites: memory, frontal (attention and executive function), and global. RESULTS: Follow-up cognitive tests were available in 334 participants after intervention (median, 4.1 years). In multivariate analyses adjusted for confounders, participants allocated to a Mediterranean diet plus olive oil scored better on the RAVLT (P = .049) and Color Trail Test part 2 (P = .04) compared with controls; no between-group differences were observed for the other cognitive tests. Similarly adjusted cognitive composites (mean z scores with 95% CIs) for changes above baseline of the memory composite were 0.04 (-0.09 to 0.18) for the Mediterranean diet plus olive oil, 0.09 (-0.05 to 0.23; P = .04 vs controls) for the Mediterranean diet plus nuts, and -0.17 (-0.32 to -0.01) for the control diet. Respective changes from baseline of the frontal cognition composite were 0.23 (0.03 to 0.43; P = .003 vs controls), 0.03 (-0.25 to 0.31), and -0.33 (-0.57 to -0.09). Changes from baseline of the global cognition composite were 0.05 (-0.11 to 0.21; P = .005 vs controls) for the Mediterranean diet plus olive oil, -0.05 (-0.27 to 0.18) for the Mediterranean diet plus nuts, and -0.38 (-0.57 to -0.18) for the control diet. All cognitive composites significantly (P < .05) decreased from baseline in controls. CONCLUSIONS AND RELEVANCE: In an older population, a Mediterranean diet supplemented with olive oil or nuts is associated with improved cognitive function. TRIAL REGISTRATION: isrctn.org Identifier: ISRCTN35739639.
pubAmerican Medical Association
doi10.1001/jamainternmed.2015.1668
issue7
volume175
pages1094-1103
eissn21686114
oafree_for_read
date2015-07-01