schliessen

Filtern

 

Bibliotheken

Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions

BACKGROUND: Previous studies have suggested that metabolite profiles of elevated acylcarnitines were associated with increased risk of cardiovascular disease (CVD) in populations with established coronary disease. However, to our knowledge, this association has not been evaluated in the context of p... Full description

Main Author: Guasch Ferré, Marta
Other Authors: Zheng, Yan , Ruiz - Canela, Miguel , Martínez - González, Miguel A. , Corella, Dolores , Estruch, Ramón , Ros, Emilio , Fitó Colomer, Montserrat , Dennis, Courtney , Morales - Gil, Isabel M. , Arós, Fernando , Fiol, Miquel , Lapetra, José , Serra - Majem, Luis , Hu, Frank B. , Salas - Salvadó, Jordi , Hruby, Adela , Clish, Clary B.
Format: Electronic Article Electronic Article
Language: English
Subjects:
Created: 2017
ID: ISSN: 0002-9165 ; DOI: 10.3945/ajcn.116.130492
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: upf10230/33227
title: Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions
format: Article
creator:
  • Guasch Ferré, Marta
  • Zheng, Yan
  • Ruiz - Canela, Miguel
  • Martínez - González, Miguel A.
  • Corella, Dolores
  • Estruch, Ramón
  • Ros, Emilio
  • Fitó Colomer, Montserrat
  • Dennis, Courtney
  • Morales - Gil, Isabel M.
  • Arós, Fernando
  • Fiol, Miquel
  • Lapetra, José
  • Serra - Majem, Luis
  • Hu, Frank B.
  • Salas - Salvadó, Jordi
  • Hruby, Adela
  • Clish, Clary B.
subjects:
  • Dieta -- Mediterrània, Regió de la
  • Cor -- Malalties
  • Mediterranean diet
  • Acylcarnitines
  • Cardiovascular disease
  • Metabolomics
ispartof:
description: BACKGROUND: Previous studies have suggested that metabolite profiles of elevated acylcarnitines were associated with increased risk of cardiovascular disease (CVD) in populations with established coronary disease. However, to our knowledge, this association has not been evaluated in the context of primary cardiovascular prevention. OBJECTIVES: We evaluated the association between 28 plasma acylcarnitine species and risk of incident CVD and the potential modifying effect of Mediterranean diet (MedDiet) interventions. DESIGN: We measured plasma acylcarnitines with the use of high-throughput liquid chromatography-tandem mass spectrometry at baseline and after 1 y of follow-up, both individually and classified into short-, medium-, or long-chain scores, in a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED) study, which is a randomized Mediterranean dietary intervention for primary cardiovascular prevention. A randomly selected subcohort (n = 751) and all available incident CVD cases (n = 229) after 4.8 y of follow-up were included in the current study. RESULTS: After adjustment for age, sex, body mass index, and other CVD risk factors, participants in the highest quartile of baseline short- and medium-chain acylcarnitines had a higher risk of CVD than did participants in the lowest quartile [HRs: 1.80 (95% CI: 1.11, 2.91; P-trend 0.01) and 1.55 (95% CI: 1.01, 2.48; P-trend = 0.04), respectively]. Increased short-chain acylcarnitines after 1 y were associated with higher risks of total CVD and stroke. Participants with higher baseline concentrations of short-, medium-, and long-chain acylcarnitines who were randomly assigned to the control group had a higher risk of CVD than did subjects with lower concentrations of acylcarnitines who were assigned to the MedDiet group. CONCLUSIONS: Our data support the conclusion that metabolite profiles characterized by elevated concentrations of acylcarnitines are independently associated with risks of total CVD and stroke alone in participants at high risk of CVD. MedDiet interventions may mitigate the adverse associations shown between higher concentrations of acylcarnitines and CVD.
language: eng
source:
identifier: ISSN: 0002-9165 ; DOI: 10.3945/ajcn.116.130492
fulltext: fulltext_linktorsrc
issn:
  • 00029165
  • 0002-9165
url: Link


@attributes
ID1757851406
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10230/33227
sourceidupf
recordidTN_upf10230/33227
sourcesystemOther
pqid1793912491
galeid455185634
display
typearticle
titlePlasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions
creatorGuasch Ferré, Marta ; Zheng, Yan ; Ruiz - Canela, Miguel ; Martínez - González, Miguel A. ; Corella, Dolores ; Estruch, Ramón ; Ros, Emilio ; Fitó Colomer, Montserrat ; Dennis, Courtney ; Morales - Gil, Isabel M. ; Arós, Fernando ; Fiol, Miquel ; Lapetra, José ; Serra - Majem, Luis ; Hu, Frank B. ; Salas - Salvadó, Jordi ; Hruby, Adela ; Clish, Clary B.
creationdate2017
identifier ISSN: 0002-9165 ; DOI: 10.3945/ajcn.116.130492
subjectDieta -- Mediterrània, Regió de la ; Cor -- Malalties ; Mediterranean diet ; Acylcarnitines ; Cardiovascular disease ; Metabolomics
descriptionBACKGROUND: Previous studies have suggested that metabolite profiles of elevated acylcarnitines were associated with increased risk of cardiovascular disease (CVD) in populations with established coronary disease. However, to our knowledge, this association has not been evaluated in the context of primary cardiovascular prevention. OBJECTIVES: We evaluated the association between 28 plasma acylcarnitine species and risk of incident CVD and the potential modifying effect of Mediterranean diet (MedDiet) interventions. DESIGN: We measured plasma acylcarnitines with the use of high-throughput liquid chromatography-tandem mass spectrometry at baseline and after 1 y of follow-up, both individually and classified into short-, medium-, or long-chain scores, in a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED) study, which is a randomized Mediterranean dietary intervention for primary cardiovascular prevention. A randomly selected subcohort (n = 751) and all available incident CVD cases (n = 229) after 4.8 y of follow-up were included in the current study. RESULTS: After adjustment for age, sex, body mass index, and other CVD risk factors, participants in the highest quartile of baseline short- and medium-chain acylcarnitines had a higher risk of CVD than did participants in the lowest quartile [HRs: 1.80 (95% CI: 1.11, 2.91; P-trend 0.01) and 1.55 (95% CI: 1.01, 2.48; P-trend = 0.04), respectively]. Increased short-chain acylcarnitines after 1 y were associated with higher risks of total CVD and stroke. Participants with higher baseline concentrations of short-, medium-, and long-chain acylcarnitines who were randomly assigned to the control group had a higher risk of CVD than did subjects with lower concentrations of acylcarnitines who were assigned to the MedDiet group. CONCLUSIONS: Our data support the conclusion that metabolite profiles characterized by elevated concentrations of acylcarnitines are independently associated with risks of total CVD and stroke alone in participants at high risk of CVD. MedDiet interventions may mitigate the adverse associations shown between higher concentrations of acylcarnitines and CVD.
languageeng
source
version7
oafree_for_read
lds50peer_reviewed
links
openurl$$Topenurl_article
linktorsrc$$Uhttp://hdl.handle.net/10230/33227$$EView_full_text_in_UPF
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Guasch Ferré, Marta
1Zheng, Yan
2Ruiz - Canela, Miguel
3Martínez - González, Miguel A.
4Corella, Dolores
5Estruch, Ramón
6Ros, Emilio
7Fitó Colomer, Montserrat
8Dennis, Courtney
9Morales - Gil, Isabel M.
10Arós, Fernando
11Fiol, Miquel
12Lapetra, José
13Serra - Majem, Luis
14Hu, Frank B.
15Salas - Salvadó, Jordi
16Hruby, Adela
17Clish, Clary B.
titlePlasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions
descriptionBACKGROUND: Previous studies have suggested that metabolite profiles of elevated acylcarnitines were associated with increased risk of cardiovascular disease (CVD) in populations with established coronary disease. However, to our knowledge, this association has not been evaluated in the context of primary cardiovascular prevention. OBJECTIVES: We evaluated the association between 28 plasma acylcarnitine species and risk of incident CVD and the potential modifying effect of Mediterranean diet (MedDiet) interventions. DESIGN: We measured plasma acylcarnitines with the use of high-throughput liquid chromatography-tandem mass spectrometry at baseline and after 1 y of follow-up, both individually and classified into short-, medium-, or long-chain scores, in a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED) study, which is a randomized Mediterranean dietary intervention for primary cardiovascular prevention. A randomly selected subcohort (n = 751) and all available incident CVD cases (n = 229) after 4.8 y of follow-up were included in the current study. RESULTS: After adjustment for age, sex, body mass index, and other CVD risk factors, participants in the highest quartile of baseline short- and medium-chain acylcarnitines had a higher risk of CVD than did participants in the lowest quartile [HRs: 1.80 (95% CI: 1.11, 2.91; P-trend 0.01) and 1.55 (95% CI: 1.01, 2.48; P-trend = 0.04), respectively]. Increased short-chain acylcarnitines after 1 y were associated with higher risks of total CVD and stroke. Participants with higher baseline concentrations of short-, medium-, and long-chain acylcarnitines who were randomly assigned to the control group had a higher risk of CVD than did subjects with lower concentrations of acylcarnitines who were assigned to the MedDiet group. CONCLUSIONS: Our data support the conclusion that metabolite profiles characterized by elevated concentrations of acylcarnitines are independently associated with risks of total CVD and stroke alone in participants at high risk of CVD. MedDiet interventions may mitigate the adverse associations shown between higher concentrations of acylcarnitines and CVD.
subject
0Dieta -- Mediterrània, Regió de la
1Cor -- Malalties
2Mediterranean diet
3Acylcarnitines
4Cardiovascular disease
5Metabolomics
general
0English
1American Society for Nutrition
210.3945/ajcn.116.130492
3Repositori Digital de la UPF (Universitat Pompeu Fabra)
sourceidupf
recordidupf10230/33227
issn
000029165
10002-9165
rsrctypearticle
creationdate2017
searchscopeupf
scopeupf
lsr30VSR-Enriched:[issue, pages, galeid, pqid, vol, eissn]
sort
titlePlasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions
authorGuasch Ferré, Marta ; Zheng, Yan ; Ruiz - Canela, Miguel ; Martínez - González, Miguel A. ; Corella, Dolores ; Estruch, Ramón ; Ros, Emilio ; Fitó Colomer, Montserrat ; Dennis, Courtney ; Morales - Gil, Isabel M. ; Arós, Fernando ; Fiol, Miquel ; Lapetra, José ; Serra - Majem, Luis ; Hu, Frank B. ; Salas - Salvadó, Jordi ; Hruby, Adela ; Clish, Clary B.
creationdate20170000
facets
frbrgroupid6058328886604191818
frbrtype5
newrecords
020171122
120171122
languageeng
creationdate2017
topic
0Dieta -- Mediterrània, Regió de la
1Cor -- Malalties
2Mediterranean diet
3Acylcarnitines
4Cardiovascular disease
5Metabolomics
collectionRepositori Digital de la UPF (Universitat Pompeu Fabra)
prefilterarticles
rsrctypearticles
creatorcontrib
0Guasch Ferré, Marta
1Zheng, Yan
2Ruiz - Canela, Miguel
3Martínez - González, Miguel A.
4Corella, Dolores
5Estruch, Ramón
6Ros, Emilio
7Fitó Colomer, Montserrat
8Dennis, Courtney
9Morales - Gil, Isabel M.
10Arós, Fernando
11Fiol, Miquel
12Lapetra, José
13Serra - Majem, Luis
14Hu, Frank B.
15Salas - Salvadó, Jordi
16Hruby, Adela
17Clish, Clary B.
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext_linktorsrc
addata
aulast
0Guasch Ferré
1Zheng
2Ruiz-Canela
3Martínez-González
4Corella
5Estruch
6Ros
7Fitó Colomer
8Dennis
9Morales-Gil
10Arós
11Fiol
12Lapetra
13Serra-Majem
14Hu
15Salas-Salvadó
16Hruby
17Clish
aufirst
0Marta
1Yan
2Miguel
3Miguel A.
4Dolores
5Ramón
6Emilio
7Montserrat
8Courtney
9Isabel M.
10Fernando
11Miquel
12José
13Luis
14Frank B.
15Jordi
16Adela
17Clary B.
au
0Guasch Ferré, Marta
1Zheng, Yan
2Ruiz - Canela, Miguel
3Martínez - González, Miguel A.
4Corella, Dolores
5Estruch, Ramón
6Ros, Emilio
7Fitó Colomer, Montserrat
8Dennis, Courtney
9Morales - Gil, Isabel M.
10Arós, Fernando
11Fiol, Miquel
12Lapetra, José
13Serra - Majem, Luis
14Hu, Frank B.
15Salas - Salvadó, Jordi
16Hruby, Adela
17Clish, Clary B.
atitlePlasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions
date2017
risdate2017
issn0002-9165
formatjournal
genrearticle
ristypeJOUR
abstractBACKGROUND: Previous studies have suggested that metabolite profiles of elevated acylcarnitines were associated with increased risk of cardiovascular disease (CVD) in populations with established coronary disease. However, to our knowledge, this association has not been evaluated in the context of primary cardiovascular prevention. OBJECTIVES: We evaluated the association between 28 plasma acylcarnitine species and risk of incident CVD and the potential modifying effect of Mediterranean diet (MedDiet) interventions. DESIGN: We measured plasma acylcarnitines with the use of high-throughput liquid chromatography-tandem mass spectrometry at baseline and after 1 y of follow-up, both individually and classified into short-, medium-, or long-chain scores, in a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED) study, which is a randomized Mediterranean dietary intervention for primary cardiovascular prevention. A randomly selected subcohort (n = 751) and all available incident CVD cases (n = 229) after 4.8 y of follow-up were included in the current study. RESULTS: After adjustment for age, sex, body mass index, and other CVD risk factors, participants in the highest quartile of baseline short- and medium-chain acylcarnitines had a higher risk of CVD than did participants in the lowest quartile [HRs: 1.80 (95% CI: 1.11, 2.91; P-trend 0.01) and 1.55 (95% CI: 1.01, 2.48; P-trend = 0.04), respectively]. Increased short-chain acylcarnitines after 1 y were associated with higher risks of total CVD and stroke. Participants with higher baseline concentrations of short-, medium-, and long-chain acylcarnitines who were randomly assigned to the control group had a higher risk of CVD than did subjects with lower concentrations of acylcarnitines who were assigned to the MedDiet group. CONCLUSIONS: Our data support the conclusion that metabolite profiles characterized by elevated concentrations of acylcarnitines are independently associated with risks of total CVD and stroke alone in participants at high risk of CVD. MedDiet interventions may mitigate the adverse associations shown between higher concentrations of acylcarnitines and CVD.
pubAmerican Society for Nutrition
doi10.3945/ajcn.116.130492
issue6
pages1408-14016
volume103
eissn19383207
oafree_for_read