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The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery

BACKGROUND: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce... Full description

Main Author: García - Layana, Alfredo
Other Authors: Gianfranco, Ciufo , Toledo, Estefania , Martínez - González, Miguel A. , Corella, Dolores , Fitó Colomer, Montserrat , Estruch, Ramón , Gómez - Gracia, Enrique , Fiol, Miquel , Lapetra, José , Serra - Majem, Luis , Pinto, Xavier , Portillo, María P. , Sorlí, J. V. , Bulló, Mònica , Vinyoles, Ernest , Sala Vila, Aleix , Ros, Emilio , Salas - Salvadó, Jordi , Arós, Fernando
Format: Electronic Article Electronic Article
Language: English
Subjects:
Created: 2017
ID: ISSN: 2072-6643 ; DOI: 10.3390/nu9050453
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recordid: upf10230/35037
title: The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery
format: Article
creator:
  • García - Layana, Alfredo
  • Gianfranco, Ciufo
  • Toledo, Estefania
  • Martínez - González, Miguel A.
  • Corella, Dolores
  • Fitó Colomer, Montserrat
  • Estruch, Ramón
  • Gómez - Gracia, Enrique
  • Fiol, Miquel
  • Lapetra, José
  • Serra - Majem, Luis
  • Pinto, Xavier
  • Portillo, María P.
  • Sorlí, J. V.
  • Bulló, Mònica
  • Vinyoles, Ernest
  • Sala Vila, Aleix
  • Ros, Emilio
  • Salas - Salvadó, Jordi
  • Arós, Fernando
subjects:
  • Cataractes -- Cirugia
  • Dieta mediterrània
  • Mediterranean diet
  • PREDIMED
  • Antioxidants
  • Cataract
  • Cataract surgery
  • Extra-virgin olive oil
  • Low-fat diet
  • Nuts
ispartof:
description: BACKGROUND: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects. METHODS: We included 5802 men and women (age range: 55-80 years) from the Prevención con Dieta Mediterránea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery. RESULTS: During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted hazard ratios were 1.03 (95% confidence interval [CI]: 0.84-1.26, p = 0.79) for the control group versus the MedDiet + EVOO group and 1.06 (95% CI: 0.86-1.31, p = 0.58) for the control group versus the MedDiet + Nuts group. CONCLUSIONS: To our knowledge, this is the first large randomized trial assessing the role of a MedDiet on the incidence of cataract surgery. Our results showed that the incidence of cataract surgery was similar in the MedDiet with EVOO, MedDiet with nuts, and low-fat diet groups. Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery.
language: eng
source:
identifier: ISSN: 2072-6643 ; DOI: 10.3390/nu9050453
fulltext: fulltext_linktorsrc
issn:
  • 20726643
  • 2072-6643
url: Link


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titleThe Effect of a Mediterranean Diet on the Incidence of Cataract Surgery
creatorGarcía - Layana, Alfredo ; Gianfranco, Ciufo ; Toledo, Estefania ; Martínez - González, Miguel A. ; Corella, Dolores ; Fitó Colomer, Montserrat ; Estruch, Ramón ; Gómez - Gracia, Enrique ; Fiol, Miquel ; Lapetra, José ; Serra - Majem, Luis ; Pinto, Xavier ; Portillo, María P. ; Sorlí, J. V. ; Bulló, Mònica ; Vinyoles, Ernest ; Sala Vila, Aleix ; Ros, Emilio ; Salas - Salvadó, Jordi ; Arós, Fernando
creationdate2017
identifier ISSN: 2072-6643 ; DOI: 10.3390/nu9050453
subjectCataractes -- Cirugia ; Dieta mediterrània ; Mediterranean diet ; PREDIMED ; Antioxidants ; Cataract ; Cataract surgery ; Extra-virgin olive oil ; Low-fat diet ; Nuts
descriptionBACKGROUND: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects. METHODS: We included 5802 men and women (age range: 55-80 years) from the Prevención con Dieta Mediterránea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery. RESULTS: During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted hazard ratios were 1.03 (95% confidence interval [CI]: 0.84-1.26, p = 0.79) for the control group versus the MedDiet + EVOO group and 1.06 (95% CI: 0.86-1.31, p = 0.58) for the control group versus the MedDiet + Nuts group. CONCLUSIONS: To our knowledge, this is the first large randomized trial assessing the role of a MedDiet on the incidence of cataract surgery. Our results showed that the incidence of cataract surgery was similar in the MedDiet with EVOO, MedDiet with nuts, and low-fat diet groups. Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery.
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titleThe Effect of a Mediterranean Diet on the Incidence of Cataract Surgery
descriptionBACKGROUND: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects. METHODS: We included 5802 men and women (age range: 55-80 years) from the Prevención con Dieta Mediterránea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery. RESULTS: During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted hazard ratios were 1.03 (95% confidence interval [CI]: 0.84-1.26, p = 0.79) for the control group versus the MedDiet + EVOO group and 1.06 (95% CI: 0.86-1.31, p = 0.58) for the control group versus the MedDiet + Nuts group. CONCLUSIONS: To our knowledge, this is the first large randomized trial assessing the role of a MedDiet on the incidence of cataract surgery. Our results showed that the incidence of cataract surgery was similar in the MedDiet with EVOO, MedDiet with nuts, and low-fat diet groups. Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery.
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authorGarcía - Layana, Alfredo ; Gianfranco, Ciufo ; Toledo, Estefania ; Martínez - González, Miguel A. ; Corella, Dolores ; Fitó Colomer, Montserrat ; Estruch, Ramón ; Gómez - Gracia, Enrique ; Fiol, Miquel ; Lapetra, José ; Serra - Majem, Luis ; Pinto, Xavier ; Portillo, María P. ; Sorlí, J. V. ; Bulló, Mònica ; Vinyoles, Ernest ; Sala Vila, Aleix ; Ros, Emilio ; Salas - Salvadó, Jordi ; Arós, Fernando
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7Extra-virgin olive oil
8Low-fat diet
9Nuts
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atitleThe Effect of a Mediterranean Diet on the Incidence of Cataract Surgery
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abstractBACKGROUND: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects. METHODS: We included 5802 men and women (age range: 55-80 years) from the Prevención con Dieta Mediterránea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery. RESULTS: During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted hazard ratios were 1.03 (95% confidence interval [CI]: 0.84-1.26, p = 0.79) for the control group versus the MedDiet + EVOO group and 1.06 (95% CI: 0.86-1.31, p = 0.58) for the control group versus the MedDiet + Nuts group. CONCLUSIONS: To our knowledge, this is the first large randomized trial assessing the role of a MedDiet on the incidence of cataract surgery. Our results showed that the incidence of cataract surgery was similar in the MedDiet with EVOO, MedDiet with nuts, and low-fat diet groups. Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery.
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volume9
issue5
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