schliessen

Filtern

 

Bibliotheken

APOLIPOPROTEIN E GENE POLYMORPHISMS AND RISK FOR CORONARY ARTERY DISEASE IN CHINESE XINJIANG UYGUR AND HAN POPULATION

Objective To examine the relationship between apolipoprotein E (Apo E) gene polymorphism and risk of coronaryartery disease (CAD), analyzing association of polymorphism with classical risk factors.Methods A total of 124 patients (including 84 Han population and 40 Uygur population) with angiographic... Full description

Journal Title: 中国医学科学杂志(英文版) 2004, Vol.19(2), pp.150-154
Main Author: Sheng-li Yang
Other Authors: Bing-xian He , Hui-liang Liu , Zuo-yun He , Hua Zhang , Jian-ping Luo , Xiu-fang Hong , Yang-chun Zou
Format: Electronic Article Electronic Article
Language: chi
Subjects:
ID: ISSN: 1001-9294 ; Classification: R3
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: wanfang_jourcmsj-e200402017
title: APOLIPOPROTEIN E GENE POLYMORPHISMS AND RISK FOR CORONARY ARTERY DISEASE IN CHINESE XINJIANG UYGUR AND HAN POPULATION
format: Article
creator:
  • Sheng-li Yang
  • Bing-xian He
  • Hui-liang Liu
  • Zuo-yun He
  • Hua Zhang
  • Jian-ping Luo
  • Xiu-fang Hong
  • Yang-chun Zou
subjects:
  • Apolipoprotein E
  • DNA Polymorphisms
  • Risk Factors
  • Coronary Artery Disease
ispartof: 中国医学科学杂志(英文版), 2004, Vol.19(2), pp.150-154
description: Objective To examine the relationship between apolipoprotein E (Apo E) gene polymorphism and risk of coronaryartery disease (CAD), analyzing association of polymorphism with classical risk factors.Methods A total of 124 patients (including 84 Han population and 40 Uygur population) with angiographically verified CAD or myocardial infarction were prospectively evaluated. Data referring to hypertension, diabetes, and tobacco consumption were recorded. The levels of total cholesterol (TC), high density lipoprotein (HDL) cholesterol, Apo A1 and B, and triglycerides (TG) were determined. DNA was obtained from 124 patients and 70 controls. In order to determine Apo E genotypes, DNA was PCR amplified and digested with HhaI. The genetic polymorphism of Apo E is due to three common alleles, epsilon (ε) 2, ε3, ε4, at a single autosomal gene locus. These alleles determine the six phenotypes E2/2, E3/3, E4/4,E4/2, E4/3, and E3/2.Results In Uygur population, the frequency of the ε2, ε3, and ε4 was 0.155, 0.648, and 0.197 respectively. In Han population, the frequency of the ε2, ε3, and ε4 was 0.081, 0.772, and 0.146 respectively. In the patient group, the frequency of the ε2, ε3, and ε4 was 0.060, 0.758, and 0.182 respectively. In the control group, the frequency of the ε2, ε3, and ε4 was 0.193, 0.671, and 0.136 respectively. ε2 frequency of Uygur' patients and controls was 0.050 and 0.290 respectively. Serum low density lipoprotein (LDL) cholesterol, TC, and TG values tended to decrease from the Apo E-4 phenotypes to Apo E-2phenotypes. When deletion polymorphism ofε2 was compared with the common risk factors for CAD, its risk ratio (RR) is 4.38.Conclusions These studies confirm and find that Apo E phenotype distribution in Uygur population differs significantly from that in Han population in Xinjiang. CAD patients have significantly lower ε2 allele and slightly higher ε3 or ε4 allele frequency than controls, especially in Uygur population. It shows protective effects ofε2 on CAD.
language: chi
source:
identifier: ISSN: 1001-9294 ; Classification: R3
fulltext: fulltext
issn:
  • 1001-9294
  • 10019294
url: Link


@attributes
ID1062193066
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordidcmsj-e200402017
sourceidwanfang_jour
recordidTN_wanfang_jourcmsj-e200402017
sourcesystemPC
pqid66702350
display
typearticle
titleAPOLIPOPROTEIN E GENE POLYMORPHISMS AND RISK FOR CORONARY ARTERY DISEASE IN CHINESE XINJIANG UYGUR AND HAN POPULATION
creatorSheng-li Yang ; Bing-xian He ; Hui-liang Liu ; Zuo-yun He ; Hua Zhang ; Jian-ping Luo ; Xiu-fang Hong ; Yang-chun Zou
identifierISSN: 1001-9294 ; Classification: R3
subjectApolipoprotein E ; DNA Polymorphisms ; Risk Factors ; Coronary Artery Disease
description
0Objective To examine the relationship between apolipoprotein E (Apo E) gene polymorphism and risk of coronaryartery disease (CAD), analyzing association of polymorphism with classical risk factors.Methods A total of 124 patients (including 84 Han population and 40 Uygur population) with angiographically verified CAD or myocardial infarction were prospectively evaluated. Data referring to hypertension, diabetes, and tobacco consumption were recorded. The levels of total cholesterol (TC), high density lipoprotein (HDL) cholesterol, Apo A1 and B, and triglycerides (TG) were determined. DNA was obtained from 124 patients and 70 controls. In order to determine Apo E genotypes, DNA was PCR amplified and digested with HhaI. The genetic polymorphism of Apo E is due to three common alleles, epsilon (ε) 2, ε3, ε4, at a single autosomal gene locus. These alleles determine the six phenotypes E2/2, E3/3, E4/4,E4/2, E4/3, and E3/2.Results In Uygur population, the frequency of the ε2, ε3, and ε4 was 0.155, 0.648, and 0.197 respectively. In Han population, the frequency of the ε2, ε3, and ε4 was 0.081, 0.772, and 0.146 respectively. In the patient group, the frequency of the ε2, ε3, and ε4 was 0.060, 0.758, and 0.182 respectively. In the control group, the frequency of the ε2, ε3, and ε4 was 0.193, 0.671, and 0.136 respectively. ε2 frequency of Uygur' patients and controls was 0.050 and 0.290 respectively. Serum low density lipoprotein (LDL) cholesterol, TC, and TG values tended to decrease from the Apo E-4 phenotypes to Apo E-2phenotypes. When deletion polymorphism ofε2 was compared with the common risk factors for CAD, its risk ratio (RR) is 4.38.Conclusions These studies confirm and find that Apo E phenotype distribution in Uygur population differs significantly from that in Han population in Xinjiang. CAD patients have significantly lower ε2 allele and slightly higher ε3 or ε4 allele frequency than controls, especially in Uygur population. It shows protective effects ofε2 on CAD.
1Journal Title in English: Chinese Medical Sciences Journal
languagechi
source
ispartof中国医学科学杂志(英文版), 2004, Vol.19(2), pp.150-154
version4
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink
0$$Uhttp://d.wanfangdata.com.cn/Periodical_cmsj-e200402017.aspx$$EView_this record_in_Wanfang_(CHINA)
1$$Uhttp://d.g.wanfangdata.com.hk/Periodical_cmsj-e200402017.aspx$$EView_this record_in_Wanfang_(HONG_KONG)
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutWanfang.html$$EView_the_Wanfang_Copyright_Statement
search
creatorcontrib
0Sheng-li Yang
1Bing-xian He
2Hui-liang Liu
3Zuo-yun He
4Hua Zhang
5Jian-ping Luo
6Xiu-fang Hong
7Yang-chun Zou
titleAPOLIPOPROTEIN E GENE POLYMORPHISMS AND RISK FOR CORONARY ARTERY DISEASE IN CHINESE XINJIANG UYGUR AND HAN POPULATION
descriptionObjective To examine the relationship between apolipoprotein E (Apo E) gene polymorphism and risk of coronaryartery disease (CAD), analyzing association of polymorphism with classical risk factors.Methods A total of 124 patients (including 84 Han population and 40 Uygur population) with angiographically verified CAD or myocardial infarction were prospectively evaluated. Data referring to hypertension, diabetes, and tobacco consumption were recorded. The levels of total cholesterol (TC), high density lipoprotein (HDL) cholesterol, Apo A1 and B, and triglycerides (TG) were determined. DNA was obtained from 124 patients and 70 controls. In order to determine Apo E genotypes, DNA was PCR amplified and digested with HhaI. The genetic polymorphism of Apo E is due to three common alleles, epsilon (ε) 2, ε3, ε4, at a single autosomal gene locus. These alleles determine the six phenotypes E2/2, E3/3, E4/4,E4/2, E4/3, and E3/2.Results In Uygur population, the frequency of the ε2, ε3, and ε4 was 0.155, 0.648, and 0.197 respectively. In Han population, the frequency of the ε2, ε3, and ε4 was 0.081, 0.772, and 0.146 respectively. In the patient group, the frequency of the ε2, ε3, and ε4 was 0.060, 0.758, and 0.182 respectively. In the control group, the frequency of the ε2, ε3, and ε4 was 0.193, 0.671, and 0.136 respectively. ε2 frequency of Uygur' patients and controls was 0.050 and 0.290 respectively. Serum low density lipoprotein (LDL) cholesterol, TC, and TG values tended to decrease from the Apo E-4 phenotypes to Apo E-2phenotypes. When deletion polymorphism ofε2 was compared with the common risk factors for CAD, its risk ratio (RR) is 4.38.Conclusions These studies confirm and find that Apo E phenotype distribution in Uygur population differs significantly from that in Han population in Xinjiang. CAD patients have significantly lower ε2 allele and slightly higher ε3 or ε4 allele frequency than controls, especially in Uygur population. It shows protective effects ofε2 on CAD.
subject
0Apolipoprotein E
1DNA Polymorphisms
2Risk Factors
3Coronary Artery Disease
general
0Chinese
1China Online Journals (Wanfang)
2R3
sourceidwanfang_jour
recordidwanfang_jourcmsj-e200402017
issn
01001-9294
110019294
rsrctypearticle
creationdate2004
searchscopewanfang_jour
scopewanfang_jour
startdate20040101
enddate20041231
addtitle
0中国医学科学杂志(英文版)
1Chinese Medical Sciences Journal
citationpf 150 pt 154 vol 19 issue 2
lsr30VSR-Enriched:[pqid]
sort
titleAPOLIPOPROTEIN E GENE POLYMORPHISMS AND RISK FOR CORONARY ARTERY DISEASE IN CHINESE XINJIANG UYGUR AND HAN POPULATION
authorSheng-li Yang ; Bing-xian He ; Hui-liang Liu ; Zuo-yun He ; Hua Zhang ; Jian-ping Luo ; Xiu-fang Hong ; Yang-chun Zou
creationdate20040000
lso0120040000
facets
frbrgroupid8193169418331877315
frbrtype5
languagechi
creationdate2004
topic
0Apolipoprotein E
1DNA Polymorphisms
2Risk Factors
3Coronary Artery Disease
collectionChina Online Journals (Wanfang)
prefilterarticles
rsrctypearticles
creatorcontrib
0Sheng-li Yang
1Bing-xian He
2Hui-liang Liu
3Zuo-yun He
4Hua Zhang
5Jian-ping Luo
6Xiu-fang Hong
7Yang-chun Zou
jtitle
0中国医学科学杂志(英文版)
1Chinese Medical Sciences Journal
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Sheng-li Yang
1Bing-xian He
2Hui-liang Liu
3Zuo-yun He
4Hua Zhang
5Jian-ping Luo
6Xiu-fang Hong
7Yang-chun Zou
atitleAPOLIPOPROTEIN E GENE POLYMORPHISMS AND RISK FOR CORONARY ARTERY DISEASE IN CHINESE XINJIANG UYGUR AND HAN POPULATION
jtitle中国医学科学杂志(英文版)
date2004
risdate2004
volume19
issue2
spage150
epage154
pages150-154
issn1001-9294
formatjournal
genrearticle
ristypeJOUR
abstractObjective To examine the relationship between apolipoprotein E (Apo E) gene polymorphism and risk of coronaryartery disease (CAD), analyzing association of polymorphism with classical risk factors.Methods A total of 124 patients (including 84 Han population and 40 Uygur population) with angiographically verified CAD or myocardial infarction were prospectively evaluated. Data referring to hypertension, diabetes, and tobacco consumption were recorded. The levels of total cholesterol (TC), high density lipoprotein (HDL) cholesterol, Apo A1 and B, and triglycerides (TG) were determined. DNA was obtained from 124 patients and 70 controls. In order to determine Apo E genotypes, DNA was PCR amplified and digested with HhaI. The genetic polymorphism of Apo E is due to three common alleles, epsilon (ε) 2, ε3, ε4, at a single autosomal gene locus. These alleles determine the six phenotypes E2/2, E3/3, E4/4,E4/2, E4/3, and E3/2.Results In Uygur population, the frequency of the ε2, ε3, and ε4 was 0.155, 0.648, and 0.197 respectively. In Han population, the frequency of the ε2, ε3, and ε4 was 0.081, 0.772, and 0.146 respectively. In the patient group, the frequency of the ε2, ε3, and ε4 was 0.060, 0.758, and 0.182 respectively. In the control group, the frequency of the ε2, ε3, and ε4 was 0.193, 0.671, and 0.136 respectively. ε2 frequency of Uygur' patients and controls was 0.050 and 0.290 respectively. Serum low density lipoprotein (LDL) cholesterol, TC, and TG values tended to decrease from the Apo E-4 phenotypes to Apo E-2phenotypes. When deletion polymorphism ofε2 was compared with the common risk factors for CAD, its risk ratio (RR) is 4.38.Conclusions These studies confirm and find that Apo E phenotype distribution in Uygur population differs significantly from that in Han population in Xinjiang. CAD patients have significantly lower ε2 allele and slightly higher ε3 or ε4 allele frequency than controls, especially in Uygur population. It shows protective effects ofε2 on CAD.