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BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair

Funding organization: supported by grants from the National Institute of Dental and Craniofacial Research, NIH (supported by R01 DE026339)

Journal Title: 骨研究(英文版) 2018, Vol.6(4), pp.355-367
Main Author: Yuxing Guo
Other Authors: Yuan Yuan , Ling Wu , Thach-Vu Ho , Junjun Jing , Hideki Sugii , Jingyuan Li , Xia Han , Jifan Feng , Chuanbin Guo , Yang Chai
Format: Electronic Article Electronic Article
Language: chi
Quelle: China Online Journals (Wanfang)
ID: ISSN: 2095-4700
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title: BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair
format: Article
creator:
  • Yuxing Guo
  • Yuan Yuan
  • Ling Wu
  • Thach-Vu Ho
  • Junjun Jing
  • Hideki Sugii
  • Jingyuan Li
  • Xia Han
  • Jifan Feng
  • Chuanbin Guo
  • Yang Chai
ispartof: 骨研究(英文版), 2018, Vol.6(4), pp.355-367
description: Funding organization: supported by grants from the National Institute of Dental and Craniofacial Research, NIH (supported by R01 DE026339)
language: chi
source: China Online Journals (Wanfang)
identifier: ISSN: 2095-4700
fulltext: fulltext
issn:
  • 2095-4700
  • 20954700
url: Link


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titleBMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair
creatorYuxing Guo ; Yuan Yuan ; Ling Wu ; Thach-Vu Ho ; Junjun Jing ; Hideki Sugii ; Jingyuan Li ; Xia Han ; Jifan Feng ; Chuanbin Guo ; Yang Chai
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0Funding organization: supported by grants from the National Institute of Dental and Craniofacial Research, NIH (supported by R01 DE026339)
1Calvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells (MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and repair. Abnormal function of osteogenic cells or diminished MSCs within the cranial suture can lead to skull defects, such as craniosynostosis. Despite the important function of each of these cell types within the cranial suture, we have limited knowledge about the role that crosstalk between them may play in regulating calvarial bone homeostasis and injury repair. Here we show that suture MSCs give rise to osteoprogenitors that show active bone morphogenetic protein (BMP) signalling and depend on BMP-mediated Indian hedgehog (IHH) signalling to balance osteogenesis and osteoclastogenesis activity. IHH signalling and receptor activator of nuclear factor kappa-Β ligand (RANKL) may function synergistically to promote the differentiation and resorption activity of osteoclasts....
2Journal Title in English: Bone Research
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titleBMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair
descriptionCalvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells (MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and repair. Abnormal function of osteogenic cells or diminished MSCs within the cranial suture can lead to skull defects, such as craniosynostosis. Despite the important function of each of these cell types within the cranial suture, we have limited knowledge about the role that crosstalk between them may play in regulating calvarial bone homeostasis and injury repair. Here we show that suture MSCs give rise to osteoprogenitors that show active bone morphogenetic protein (BMP) signalling and depend on BMP-mediated Indian hedgehog (IHH) signalling to balance osteogenesis and osteoclastogenesis activity. IHH signalling and receptor activator of nuclear factor kappa-Β ligand (RANKL) may function synergistically to promote the differentiation and resorption activity of osteoclasts....
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titleBMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair
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abstractCalvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells (MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and repair. Abnormal function of osteogenic cells or diminished MSCs within the cranial suture can lead to skull defects, such as craniosynostosis. Despite the important function of each of these cell types within the cranial suture, we have limited knowledge about the role that crosstalk between them may play in regulating calvarial bone homeostasis and injury repair. Here we show that suture MSCs give rise to osteoprogenitors that show active bone morphogenetic protein (BMP) signalling and depend on BMP-mediated Indian hedgehog (IHH) signalling to balance osteogenesis and osteoclastogenesis activity. IHH signalling and receptor activator of nuclear factor kappa-Β ligand (RANKL) may function synergistically to promote the differentiation and resorption activity of osteoclasts....