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Advances in Skin Regeneration: Application of Electrospun Scaffolds

The paucity of cellular and molecular signals essential for normal wound healing makes severe dermatological ulcers stubborn to heal. The novel strategies of skin regenerative treatments are focused on the development of biologically responsive scaffolds accompanied by cells and multiple biomolecule... Full description

Journal Title: Advanced Healthcare Materials June 2015, Vol.4(8), pp.1114-1133
Main Author: Norouzi, Mohammad
Other Authors: Boroujeni, Samaneh Moghadasi , Omidvarkordshouli, Noushin , Soleimani, Masoud
Format: Electronic Article Electronic Article
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ID: ISSN: 2192-2640 ; E-ISSN: 2192-2659 ; DOI: 10.1002/adhm.201500001
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recordid: wj10.1002/adhm.201500001
title: Advances in Skin Regeneration: Application of Electrospun Scaffolds
format: Article
creator:
  • Norouzi, Mohammad
  • Boroujeni, Samaneh Moghadasi
  • Omidvarkordshouli, Noushin
  • Soleimani, Masoud
subjects:
  • Electrospun Scaffolds
  • Biocompatible Polymers
  • Bioactive Agents
  • Skin Tissue Engineering
  • Wound Healing
ispartof: Advanced Healthcare Materials, June 2015, Vol.4(8), pp.1114-1133
description: The paucity of cellular and molecular signals essential for normal wound healing makes severe dermatological ulcers stubborn to heal. The novel strategies of skin regenerative treatments are focused on the development of biologically responsive scaffolds accompanied by cells and multiple biomolecules resembling structural and biochemical cues of the natural extracellular matrix (ECM). Electrospun nanofibrous scaffolds provide similar architecture to the ECM leading to enhancement of cell adhesion, proliferation, migration and neo tissue formation. This Review surveys the application of biocompatible natural, synthetic and composite polymers to fabricate electrospun scaffolds as skin substitutes and wound dressings. Furthermore, the application of biomolecules and therapeutic agents in the nanofibrous scaffolds viz growth factors, genes, antibiotics, silver nanoparticles, and natural medicines with the aim of ameliorating cellular behavior, wound healing, and skin regeneration are discussed. , biomolecules (i.e., growth factors and genes) and therapeutic agents (i.e., antibiotics, nanoparticles, and natural medicine) in order to fabricate bioactive electrospun scaffolds as skin substitutes and wound dressings.
language:
source:
identifier: ISSN: 2192-2640 ; E-ISSN: 2192-2659 ; DOI: 10.1002/adhm.201500001
fulltext: fulltext
issn:
  • 2192-2640
  • 21922640
  • 2192-2659
  • 21922659
url: Link


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titleAdvances in Skin Regeneration: Application of Electrospun Scaffolds
creatorNorouzi, Mohammad ; Boroujeni, Samaneh Moghadasi ; Omidvarkordshouli, Noushin ; Soleimani, Masoud
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subjectElectrospun Scaffolds ; Biocompatible Polymers ; Bioactive Agents ; Skin Tissue Engineering ; Wound Healing
descriptionThe paucity of cellular and molecular signals essential for normal wound healing makes severe dermatological ulcers stubborn to heal. The novel strategies of skin regenerative treatments are focused on the development of biologically responsive scaffolds accompanied by cells and multiple biomolecules resembling structural and biochemical cues of the natural extracellular matrix (ECM). Electrospun nanofibrous scaffolds provide similar architecture to the ECM leading to enhancement of cell adhesion, proliferation, migration and neo tissue formation. This Review surveys the application of biocompatible natural, synthetic and composite polymers to fabricate electrospun scaffolds as skin substitutes and wound dressings. Furthermore, the application of biomolecules and therapeutic agents in the nanofibrous scaffolds viz growth factors, genes, antibiotics, silver nanoparticles, and natural medicines with the aim of ameliorating cellular behavior, wound healing, and skin regeneration are discussed. , biomolecules (i.e., growth factors and genes) and therapeutic agents (i.e., antibiotics, nanoparticles, and natural medicine) in order to fabricate bioactive electrospun scaffolds as skin substitutes and wound dressings.
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descriptionThe paucity of cellular and molecular signals essential for normal wound healing makes severe dermatological ulcers stubborn to heal. The novel strategies of skin regenerative treatments are focused on the development of biologically responsive scaffolds accompanied by cells and multiple biomolecules resembling structural and biochemical cues of the natural extracellular matrix (ECM). Electrospun nanofibrous scaffolds provide similar architecture to the ECM leading to enhancement of cell adhesion, proliferation, migration and neo tissue formation. This Review surveys the application of biocompatible natural, synthetic and composite polymers to fabricate electrospun scaffolds as skin substitutes and wound dressings. Furthermore, the application of biomolecules and therapeutic agents in the nanofibrous scaffolds viz growth factors, genes, antibiotics, silver nanoparticles, and natural medicines with the aim of ameliorating cellular behavior, wound healing, and skin regeneration are discussed. , biomolecules (i.e., growth factors and genes) and therapeutic agents (i.e., antibiotics, nanoparticles, and natural medicine) in order to fabricate bioactive electrospun scaffolds as skin substitutes and wound dressings.
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abstractThe paucity of cellular and molecular signals essential for normal wound healing makes severe dermatological ulcers stubborn to heal. The novel strategies of skin regenerative treatments are focused on the development of biologically responsive scaffolds accompanied by cells and multiple biomolecules resembling structural and biochemical cues of the natural extracellular matrix (ECM). Electrospun nanofibrous scaffolds provide similar architecture to the ECM leading to enhancement of cell adhesion, proliferation, migration and neo tissue formation. This Review surveys the application of biocompatible natural, synthetic and composite polymers to fabricate electrospun scaffolds as skin substitutes and wound dressings. Furthermore, the application of biomolecules and therapeutic agents in the nanofibrous scaffolds viz growth factors, genes, antibiotics, silver nanoparticles, and natural medicines with the aim of ameliorating cellular behavior, wound healing, and skin regeneration are discussed. , biomolecules (i.e., growth factors and genes) and therapeutic agents (i.e., antibiotics, nanoparticles, and natural medicine) in order to fabricate bioactive electrospun scaffolds as skin substitutes and wound dressings.
doi10.1002/adhm.201500001
pages1114-1133
date2015-06