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Investigation of Single‐Drug‐Encapsulating Liposomes using the Nano‐Impact Method

Encapsulating liposomes are widely used for controlled drug delivery. We report the use of nano‐impact experiments for the electrochemical attomolar quantification of the liposome load, uniquely at the single liposome level, using vitamin C encapsulated liposomes as a model. The size of the liposome... Full description

Journal Title: Angewandte Chemie International Edition 08 December 2014, Vol.53(50), pp.13928-13930
Main Author: Cheng, Wei
Other Authors: Compton, Richard G.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1433-7851 ; E-ISSN: 1521-3773 ; DOI: 10.1002/anie.201408934
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recordid: wj10.1002/anie.201408934
title: Investigation of Single‐Drug‐Encapsulating Liposomes using the Nano‐Impact Method
format: Article
creator:
  • Cheng, Wei
  • Compton, Richard G.
subjects:
  • Drug Delivery
  • Electrochemistry
  • Liposomes
  • Nano‐Impact Method
  • Nanoparticles
ispartof: Angewandte Chemie International Edition, 08 December 2014, Vol.53(50), pp.13928-13930
description: Encapsulating liposomes are widely used for controlled drug delivery. We report the use of nano‐impact experiments for the electrochemical attomolar quantification of the liposome load, uniquely at the single liposome level, using vitamin C encapsulated liposomes as a model. The size of the liposomes and their picomolar concentration are also determined in biological buffer in real time. : Encapsulating liposomes are widely used for controlled drug delivery. Nano‐impact experiments are employed for the electrochemical attomolar quantification of the contents of a vitamin C encapsulating liposome at the single liposome level. Liposome sizing and their picomolar concentration are also determined in biological buffer in real time.
language: eng
source:
identifier: ISSN: 1433-7851 ; E-ISSN: 1521-3773 ; DOI: 10.1002/anie.201408934
fulltext: fulltext
issn:
  • 1433-7851
  • 14337851
  • 1521-3773
  • 15213773
url: Link


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titleInvestigation of Single‐Drug‐Encapsulating Liposomes using the Nano‐Impact Method
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subjectDrug Delivery ; Electrochemistry ; Liposomes ; Nano‐Impact Method ; Nanoparticles
descriptionEncapsulating liposomes are widely used for controlled drug delivery. We report the use of nano‐impact experiments for the electrochemical attomolar quantification of the liposome load, uniquely at the single liposome level, using vitamin C encapsulated liposomes as a model. The size of the liposomes and their picomolar concentration are also determined in biological buffer in real time. : Encapsulating liposomes are widely used for controlled drug delivery. Nano‐impact experiments are employed for the electrochemical attomolar quantification of the contents of a vitamin C encapsulating liposome at the single liposome level. Liposome sizing and their picomolar concentration are also determined in biological buffer in real time.
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titleInvestigation of Single‐Drug‐Encapsulating Liposomes using the Nano‐Impact Method
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abstractEncapsulating liposomes are widely used for controlled drug delivery. We report the use of nano‐impact experiments for the electrochemical attomolar quantification of the liposome load, uniquely at the single liposome level, using vitamin C encapsulated liposomes as a model. The size of the liposomes and their picomolar concentration are also determined in biological buffer in real time. : Encapsulating liposomes are widely used for controlled drug delivery. Nano‐impact experiments are employed for the electrochemical attomolar quantification of the contents of a vitamin C encapsulating liposome at the single liposome level. Liposome sizing and their picomolar concentration are also determined in biological buffer in real time.
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doi10.1002/anie.201408934
pages13928-13930
date2014-12-08