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A High‐Throughput Platform for Formulating and Screening Multifunctional Nanoparticles Capable of Simultaneous Delivery of Genes and Transcription Factors

Simultaneous delivery of multiple genes and proteins (e.g., transcription factors; TFs) is an emerging issue surrounding therapeutic research due to their ability to regulate cellular circuitry. Current gene and protein delivery strategies, however, are based on slow batch synthesis, which is ineffe... Full description

Journal Title: Angewandte Chemie International Edition 04 January 2016, Vol.55(1), pp.169-173
Main Author: Liu, Yang
Other Authors: Du, Juanjuan , Choi, Jin‐Sil , Chen, Kuan‐Ju , Hou, Shuang , Yan, Ming , Lin, Wei‐Yu , Chen, Kevin Sean , Ro, Tracy , Lipshutz, Gerald S. , Wu, Lily , Shi, Linqi , Lu, Yunfeng , Tseng, Hsian‐Rong , Wang, Hao
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1433-7851 ; E-ISSN: 1521-3773 ; DOI: 10.1002/anie.201507546
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recordid: wj10.1002/anie.201507546
title: A High‐Throughput Platform for Formulating and Screening Multifunctional Nanoparticles Capable of Simultaneous Delivery of Genes and Transcription Factors
format: Article
creator:
  • Liu, Yang
  • Du, Juanjuan
  • Choi, Jin‐Sil
  • Chen, Kuan‐Ju
  • Hou, Shuang
  • Yan, Ming
  • Lin, Wei‐Yu
  • Chen, Kevin Sean
  • Ro, Tracy
  • Lipshutz, Gerald S.
  • Wu, Lily
  • Shi, Linqi
  • Lu, Yunfeng
  • Tseng, Hsian‐Rong
  • Wang, Hao
subjects:
  • Biomolecular Delivery
  • Microfluidics
  • Nanoparticles
  • Supramolecular Chemistry
  • Transcription Factors
ispartof: Angewandte Chemie International Edition, 04 January 2016, Vol.55(1), pp.169-173
description: Simultaneous delivery of multiple genes and proteins (e.g., transcription factors; TFs) is an emerging issue surrounding therapeutic research due to their ability to regulate cellular circuitry. Current gene and protein delivery strategies, however, are based on slow batch synthesis, which is ineffective, poorly controlled, and incapable of simultaneous delivery of both genes and proteins with synergistic functions. Consequently, advances in this field have been limited to in vitro studies. Here, by integrating microfluidic technologies with a supramolecular synthetic strategy, we present a high‐throughput approach for formulating and screening multifunctional supramolecular nanoparticles (MFSNPs) self‐assembled from a collection of functional modules to achieve simultaneous delivery of one gene and TF with unprecedented efficiency both in vitro and in vivo. We envision that this new approach could open a new avenue for immunotherapy, stem cell reprogramming, and other therapeutic applications. : Integration of microfluidic systems with a supramolecular synthetic strategy results in a high‐throughput approach to formulating and screening multifunctional supramolecular nanoparticles (see picture). The nanoparticles are self‐assembled from a collection of functional modules (proteins, genes, ligands, and a scaffold) and can simultaneously deliver both a gene and transcription factor either in vitro or in vivo.
language: eng
source:
identifier: ISSN: 1433-7851 ; E-ISSN: 1521-3773 ; DOI: 10.1002/anie.201507546
fulltext: fulltext
issn:
  • 1433-7851
  • 14337851
  • 1521-3773
  • 15213773
url: Link


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titleA High‐Throughput Platform for Formulating and Screening Multifunctional Nanoparticles Capable of Simultaneous Delivery of Genes and Transcription Factors
creatorLiu, Yang ; Du, Juanjuan ; Choi, Jin‐Sil ; Chen, Kuan‐Ju ; Hou, Shuang ; Yan, Ming ; Lin, Wei‐Yu ; Chen, Kevin Sean ; Ro, Tracy ; Lipshutz, Gerald S. ; Wu, Lily ; Shi, Linqi ; Lu, Yunfeng ; Tseng, Hsian‐Rong ; Wang, Hao
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subjectBiomolecular Delivery ; Microfluidics ; Nanoparticles ; Supramolecular Chemistry ; Transcription Factors
descriptionSimultaneous delivery of multiple genes and proteins (e.g., transcription factors; TFs) is an emerging issue surrounding therapeutic research due to their ability to regulate cellular circuitry. Current gene and protein delivery strategies, however, are based on slow batch synthesis, which is ineffective, poorly controlled, and incapable of simultaneous delivery of both genes and proteins with synergistic functions. Consequently, advances in this field have been limited to in vitro studies. Here, by integrating microfluidic technologies with a supramolecular synthetic strategy, we present a high‐throughput approach for formulating and screening multifunctional supramolecular nanoparticles (MFSNPs) self‐assembled from a collection of functional modules to achieve simultaneous delivery of one gene and TF with unprecedented efficiency both in vitro and in vivo. We envision that this new approach could open a new avenue for immunotherapy, stem cell reprogramming, and other therapeutic applications. : Integration of microfluidic systems with a supramolecular synthetic strategy results in a high‐throughput approach to formulating and screening multifunctional supramolecular nanoparticles (see picture). The nanoparticles are self‐assembled from a collection of functional modules (proteins, genes, ligands, and a scaffold) and can simultaneously deliver both a gene and transcription factor either in vitro or in vivo.
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titleA High‐Throughput Platform for Formulating and Screening Multifunctional Nanoparticles Capable of Simultaneous Delivery of Genes and Transcription Factors
descriptionSimultaneous delivery of multiple genes and proteins (e.g., transcription factors; TFs) is an emerging issue surrounding therapeutic research due to their ability to regulate cellular circuitry. Current gene and protein delivery strategies, however, are based on slow batch synthesis, which is ineffective, poorly controlled, and incapable of simultaneous delivery of both genes and proteins with synergistic functions. Consequently, advances in this field have been limited to in vitro studies. Here, by integrating microfluidic technologies with a supramolecular synthetic strategy, we present a high‐throughput approach for formulating and screening multifunctional supramolecular nanoparticles (MFSNPs) self‐assembled from a collection of functional modules to achieve simultaneous delivery of one gene and TF with unprecedented efficiency both in vitro and in vivo. We envision that this new approach could open a new avenue for immunotherapy, stem cell reprogramming, and other therapeutic applications. : Integration of microfluidic systems with a supramolecular synthetic strategy results in a high‐throughput approach to formulating and screening multifunctional supramolecular nanoparticles (see picture). The nanoparticles are self‐assembled from a collection of functional modules (proteins, genes, ligands, and a scaffold) and can simultaneously deliver both a gene and transcription factor either in vitro or in vivo.
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titleA High‐Throughput Platform for Formulating and Screening Multifunctional Nanoparticles Capable of Simultaneous Delivery of Genes and Transcription Factors
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abstractSimultaneous delivery of multiple genes and proteins (e.g., transcription factors; TFs) is an emerging issue surrounding therapeutic research due to their ability to regulate cellular circuitry. Current gene and protein delivery strategies, however, are based on slow batch synthesis, which is ineffective, poorly controlled, and incapable of simultaneous delivery of both genes and proteins with synergistic functions. Consequently, advances in this field have been limited to in vitro studies. Here, by integrating microfluidic technologies with a supramolecular synthetic strategy, we present a high‐throughput approach for formulating and screening multifunctional supramolecular nanoparticles (MFSNPs) self‐assembled from a collection of functional modules to achieve simultaneous delivery of one gene and TF with unprecedented efficiency both in vitro and in vivo. We envision that this new approach could open a new avenue for immunotherapy, stem cell reprogramming, and other therapeutic applications. : Integration of microfluidic systems with a supramolecular synthetic strategy results in a high‐throughput approach to formulating and screening multifunctional supramolecular nanoparticles (see picture). The nanoparticles are self‐assembled from a collection of functional modules (proteins, genes, ligands, and a scaffold) and can simultaneously deliver both a gene and transcription factor either in vitro or in vivo.
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