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Preparation and characterization of mPEG‐g‐α‐zein biohybrid micelles as a nano‐carrier

A new kind of block copolymer micelles methoxy polyethylene glycol (mPEG) grafted α‐zein protein (mPEG‐‐α‐zein) was synthesized. The chemical composition of mPEG‐‐α‐zein was identified with the help of FT‐IR and H‐NMR. The biohybrid polymer can self‐assemble into spherical core–shell nanoparticles i... Full description

Journal Title: Journal of Applied Polymer Science 10 October 2015, Vol.132(38), pp.n/a-n/a
Main Author: Song, Rongguang
Other Authors: Zhou, Yihan , Li, Yanchun , Yang, Zechuan , Li, Fan , Huang, Qingrong , Shi, Tongfei , Zhang, Guo
Format: Electronic Article Electronic Article
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ID: ISSN: 0021-8995 ; E-ISSN: 1097-4628 ; DOI: 10.1002/app.42555
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recordid: wj10.1002/app.42555
title: Preparation and characterization of mPEG‐g‐α‐zein biohybrid micelles as a nano‐carrier
format: Article
creator:
  • Song, Rongguang
  • Zhou, Yihan
  • Li, Yanchun
  • Yang, Zechuan
  • Li, Fan
  • Huang, Qingrong
  • Shi, Tongfei
  • Zhang, Guo
subjects:
  • Biomaterials
  • Biomedical Applications
  • Degradation
  • Nanoparticles
  • Nanowires And Nanocrystals
ispartof: Journal of Applied Polymer Science, 10 October 2015, Vol.132(38), pp.n/a-n/a
description: A new kind of block copolymer micelles methoxy polyethylene glycol (mPEG) grafted α‐zein protein (mPEG‐‐α‐zein) was synthesized. The chemical composition of mPEG‐‐α‐zein was identified with the help of FT‐IR and H‐NMR. The biohybrid polymer can self‐assemble into spherical core–shell nanoparticles in aqueous solution. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) were used to investigate the self‐assembled morphology of mPEG‐‐α‐zein. Dynamic light scattering (DLS) results showed that the particle size of mPEG‐‐α‐zein was about 90 nm. Moreover, the nanoparticles had a very low critical micelle concentration value with only 0.02 mg/mL. Then, the anticancer drug curcumin (CUR) was encapsulated into the biohybrid polymer micelles. The drug release profile showed a zero‐order release of CUR up to 12 h at 37°C. Cell viability studies revealed that the mPEG‐‐α‐zein polymer exhibited low cytotoxicity for HepG2 cells (human hepatoma cells). Consequently, the mPEG‐‐α‐zein micelles can be used as a potential nano‐carrier to encapsulate hydrophobic drugs and nutrients. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. , , 42555.
language:
source:
identifier: ISSN: 0021-8995 ; E-ISSN: 1097-4628 ; DOI: 10.1002/app.42555
fulltext: fulltext
issn:
  • 0021-8995
  • 00218995
  • 1097-4628
  • 10974628
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titlePreparation and characterization of mPEG‐g‐α‐zein biohybrid micelles as a nano‐carrier
creatorSong, Rongguang ; Zhou, Yihan ; Li, Yanchun ; Yang, Zechuan ; Li, Fan ; Huang, Qingrong ; Shi, Tongfei ; Zhang, Guo
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subjectBiomaterials ; Biomedical Applications ; Degradation ; Nanoparticles ; Nanowires And Nanocrystals
descriptionA new kind of block copolymer micelles methoxy polyethylene glycol (mPEG) grafted α‐zein protein (mPEG‐‐α‐zein) was synthesized. The chemical composition of mPEG‐‐α‐zein was identified with the help of FT‐IR and H‐NMR. The biohybrid polymer can self‐assemble into spherical core–shell nanoparticles in aqueous solution. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) were used to investigate the self‐assembled morphology of mPEG‐‐α‐zein. Dynamic light scattering (DLS) results showed that the particle size of mPEG‐‐α‐zein was about 90 nm. Moreover, the nanoparticles had a very low critical micelle concentration value with only 0.02 mg/mL. Then, the anticancer drug curcumin (CUR) was encapsulated into the biohybrid polymer micelles. The drug release profile showed a zero‐order release of CUR up to 12 h at 37°C. Cell viability studies revealed that the mPEG‐‐α‐zein polymer exhibited low cytotoxicity for HepG2 cells (human hepatoma cells). Consequently, the mPEG‐‐α‐zein micelles can be used as a potential nano‐carrier to encapsulate hydrophobic drugs and nutrients. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. , , 42555.
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titlePreparation and characterization of mPEG‐g‐α‐zein biohybrid micelles as a nano‐carrier
descriptionA new kind of block copolymer micelles methoxy polyethylene glycol (mPEG) grafted α‐zein protein (mPEG‐‐α‐zein) was synthesized. The chemical composition of mPEG‐‐α‐zein was identified with the help of FT‐IR and H‐NMR. The biohybrid polymer can self‐assemble into spherical core–shell nanoparticles in aqueous solution. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) were used to investigate the self‐assembled morphology of mPEG‐‐α‐zein. Dynamic light scattering (DLS) results showed that the particle size of mPEG‐‐α‐zein was about 90 nm. Moreover, the nanoparticles had a very low critical micelle concentration value with only 0.02 mg/mL. Then, the anticancer drug curcumin (CUR) was encapsulated into the biohybrid polymer micelles. The drug release profile showed a zero‐order release of CUR up to 12 h at 37°C. Cell viability studies revealed that the mPEG‐‐α‐zein polymer exhibited low cytotoxicity for HepG2 cells (human hepatoma cells). Consequently, the mPEG‐‐α‐zein micelles can be used as a potential nano‐carrier to encapsulate hydrophobic drugs and nutrients. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. , , 42555.
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abstractA new kind of block copolymer micelles methoxy polyethylene glycol (mPEG) grafted α‐zein protein (mPEG‐‐α‐zein) was synthesized. The chemical composition of mPEG‐‐α‐zein was identified with the help of FT‐IR and H‐NMR. The biohybrid polymer can self‐assemble into spherical core–shell nanoparticles in aqueous solution. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) were used to investigate the self‐assembled morphology of mPEG‐‐α‐zein. Dynamic light scattering (DLS) results showed that the particle size of mPEG‐‐α‐zein was about 90 nm. Moreover, the nanoparticles had a very low critical micelle concentration value with only 0.02 mg/mL. Then, the anticancer drug curcumin (CUR) was encapsulated into the biohybrid polymer micelles. The drug release profile showed a zero‐order release of CUR up to 12 h at 37°C. Cell viability studies revealed that the mPEG‐‐α‐zein polymer exhibited low cytotoxicity for HepG2 cells (human hepatoma cells). Consequently, the mPEG‐‐α‐zein micelles can be used as a potential nano‐carrier to encapsulate hydrophobic drugs and nutrients. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. , , 42555.
doi10.1002/app.42555
pages42555/1-42555/6
date2015-10-10