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Drug susceptibility of matrix‐encapsulated Candida albicans nano‐biofilms

Nano‐scale cultures of biofilms encapsulated in collagen or alginate matrices in a microarray were used to test the susceptibility of antifungal drugs. Srinivasan et al show that these cultures exhibit differential response to drugs depending upon the interaction between the drug and the matrix. The... Full description

Journal Title: Biotechnology and Bioengineering February 2014, Vol.111(2), pp.418-424
Main Author: Srinivasan, Anand
Other Authors: Gupta, Celia Macias , Agrawal, C. Mauli , Leung, Kai P. , Lopez‐Ribot, Jose L. , Ramasubramanian, Anand K.
Format: Electronic Article Electronic Article
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ID: ISSN: 0006-3592 ; E-ISSN: 1097-0290 ; DOI: 10.1002/bit.25120
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recordid: wj10.1002/bit.25120
title: Drug susceptibility of matrix‐encapsulated Candida albicans nano‐biofilms
format: Article
creator:
  • Srinivasan, Anand
  • Gupta, Celia Macias
  • Agrawal, C. Mauli
  • Leung, Kai P.
  • Lopez‐Ribot, Jose L.
  • Ramasubramanian, Anand K.
subjects:
  • Hydrogels
  • Microarray
  • Candida Albicans
  • Biofilms
  • High‐Throughput
  • Drug Screening
  • Caspofungin
ispartof: Biotechnology and Bioengineering, February 2014, Vol.111(2), pp.418-424
description: Nano‐scale cultures of biofilms encapsulated in collagen or alginate matrices in a microarray were used to test the susceptibility of antifungal drugs. Srinivasan et al show that these cultures exhibit differential response to drugs depending upon the interaction between the drug and the matrix. Their results underscore the choice of matrix as a critical parameter in 3D cell encapsulation for drug discovery and tissue engineering applications.
language:
source:
identifier: ISSN: 0006-3592 ; E-ISSN: 1097-0290 ; DOI: 10.1002/bit.25120
fulltext: fulltext
issn:
  • 0006-3592
  • 00063592
  • 1097-0290
  • 10970290
url: Link


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titleDrug susceptibility of matrix‐encapsulated Candida albicans nano‐biofilms
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subjectHydrogels ; Microarray ; Candida Albicans ; Biofilms ; High‐Throughput ; Drug Screening ; Caspofungin
descriptionNano‐scale cultures of biofilms encapsulated in collagen or alginate matrices in a microarray were used to test the susceptibility of antifungal drugs. Srinivasan et al show that these cultures exhibit differential response to drugs depending upon the interaction between the drug and the matrix. Their results underscore the choice of matrix as a critical parameter in 3D cell encapsulation for drug discovery and tissue engineering applications.
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titleDrug susceptibility of matrix‐encapsulated Candida albicans nano‐biofilms
descriptionNano‐scale cultures of biofilms encapsulated in collagen or alginate matrices in a microarray were used to test the susceptibility of antifungal drugs. Srinivasan et al show that these cultures exhibit differential response to drugs depending upon the interaction between the drug and the matrix. Their results underscore the choice of matrix as a critical parameter in 3D cell encapsulation for drug discovery and tissue engineering applications.
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abstractNano‐scale cultures of biofilms encapsulated in collagen or alginate matrices in a microarray were used to test the susceptibility of antifungal drugs. Srinivasan et al show that these cultures exhibit differential response to drugs depending upon the interaction between the drug and the matrix. Their results underscore the choice of matrix as a critical parameter in 3D cell encapsulation for drug discovery and tissue engineering applications.
doi10.1002/bit.25120
pages418
date2014-02