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A pumpless multi‐organ‐on‐a‐chip (MOC) combined with a pharmacokinetic–pharmacodynamic (PK–PD) model

Multi‐organ‐on‐a‐chip recapitulates simultaneous metabolism and cell‐killing effect of drugs, and its action inside the chip is simulated with a PK–PD model, providing insight into the action of the drug.

Journal Title: Biotechnology and Bioengineering February 2017, Vol.114(2), pp.432-443
Main Author: Lee, Hyuna
Other Authors: Kim, Dae Shik , Ha, Sang Keun , Choi, Inwook , Lee, Jong Min , Sung, Jong Hwan
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0006-3592 ; E-ISSN: 1097-0290 ; DOI: 10.1002/bit.26087
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recordid: wj10.1002/bit.26087
title: A pumpless multi‐organ‐on‐a‐chip (MOC) combined with a pharmacokinetic–pharmacodynamic (PK–PD) model
format: Article
creator:
  • Lee, Hyuna
  • Kim, Dae Shik
  • Ha, Sang Keun
  • Choi, Inwook
  • Lee, Jong Min
  • Sung, Jong Hwan
subjects:
  • Multi‐Organ‐On‐A‐Chip
  • Pk–Pd Modeling
  • Microfluidics
ispartof: Biotechnology and Bioengineering, February 2017, Vol.114(2), pp.432-443
description: Multi‐organ‐on‐a‐chip recapitulates simultaneous metabolism and cell‐killing effect of drugs, and its action inside the chip is simulated with a PK–PD model, providing insight into the action of the drug.
language:
source:
identifier: ISSN: 0006-3592 ; E-ISSN: 1097-0290 ; DOI: 10.1002/bit.26087
fulltext: fulltext
issn:
  • 0006-3592
  • 00063592
  • 1097-0290
  • 10970290
url: Link


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titleA pumpless multi‐organ‐on‐a‐chip (MOC) combined with a pharmacokinetic–pharmacodynamic (PK–PD) model
authorLee, Hyuna ; Kim, Dae Shik ; Ha, Sang Keun ; Choi, Inwook ; Lee, Jong Min ; Sung, Jong Hwan
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abstractMulti‐organ‐on‐a‐chip recapitulates simultaneous metabolism and cell‐killing effect of drugs, and its action inside the chip is simulated with a PK–PD model, providing insight into the action of the drug.
doi10.1002/bit.26087
pages432-443
date2017-02