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Creating homogenous strain distribution within 3D cell‐encapsulated constructs using a simple and cost‐effective uniaxial tensile bioreactor: Design and validation study

A uniaxial tensile strain bioreactor consisting of silicone‐based loading chambers driven by a stepper motor‐ball screw actuation system was designed to apply grip‐free stretching of cell‐encapsulated 3D collagen constructs. The lack of gripping eliminated abnormally high strain concentrations at it... Full description

Journal Title: Biotechnology and Bioengineering August 2017, Vol.114(8), pp.1878-1887
Main Author: Subramanian, Gayathri
Other Authors: Elsaadany, Mostafa , Bialorucki, Callan , Yildirim‐Ayan, Eda
Format: Electronic Article Electronic Article
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ID: ISSN: 0006-3592 ; E-ISSN: 1097-0290 ; DOI: 10.1002/bit.26304
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recordid: wj10.1002/bit.26304
title: Creating homogenous strain distribution within 3D cell‐encapsulated constructs using a simple and cost‐effective uniaxial tensile bioreactor: Design and validation study
format: Article
creator:
  • Subramanian, Gayathri
  • Elsaadany, Mostafa
  • Bialorucki, Callan
  • Yildirim‐Ayan, Eda
subjects:
  • Bioreactor
  • Mechanical Loading
  • Uniaxial Tensile Strain
  • 3d Collagen Constructs
ispartof: Biotechnology and Bioengineering, August 2017, Vol.114(8), pp.1878-1887
description: A uniaxial tensile strain bioreactor consisting of silicone‐based loading chambers driven by a stepper motor‐ball screw actuation system was designed to apply grip‐free stretching of cell‐encapsulated 3D collagen constructs. The lack of gripping eliminated abnormally high strain concentrations at its ends thereby producing enlarged homogenous strain profiles over 60% of the construct length at different physiological loading strains and frequencies, along with promoting cell viability and matrix organization within the 3D collagen constructs.
language:
source:
identifier: ISSN: 0006-3592 ; E-ISSN: 1097-0290 ; DOI: 10.1002/bit.26304
fulltext: fulltext
issn:
  • 0006-3592
  • 00063592
  • 1097-0290
  • 10970290
url: Link


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titleCreating homogenous strain distribution within 3D cell‐encapsulated constructs using a simple and cost‐effective uniaxial tensile bioreactor: Design and validation study
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subjectBioreactor ; Mechanical Loading ; Uniaxial Tensile Strain ; 3d Collagen Constructs
descriptionA uniaxial tensile strain bioreactor consisting of silicone‐based loading chambers driven by a stepper motor‐ball screw actuation system was designed to apply grip‐free stretching of cell‐encapsulated 3D collagen constructs. The lack of gripping eliminated abnormally high strain concentrations at its ends thereby producing enlarged homogenous strain profiles over 60% of the construct length at different physiological loading strains and frequencies, along with promoting cell viability and matrix organization within the 3D collagen constructs.
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titleCreating homogenous strain distribution within 3D cell‐encapsulated constructs using a simple and cost‐effective uniaxial tensile bioreactor: Design and validation study
descriptionA uniaxial tensile strain bioreactor consisting of silicone‐based loading chambers driven by a stepper motor‐ball screw actuation system was designed to apply grip‐free stretching of cell‐encapsulated 3D collagen constructs. The lack of gripping eliminated abnormally high strain concentrations at its ends thereby producing enlarged homogenous strain profiles over 60% of the construct length at different physiological loading strains and frequencies, along with promoting cell viability and matrix organization within the 3D collagen constructs.
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abstractA uniaxial tensile strain bioreactor consisting of silicone‐based loading chambers driven by a stepper motor‐ball screw actuation system was designed to apply grip‐free stretching of cell‐encapsulated 3D collagen constructs. The lack of gripping eliminated abnormally high strain concentrations at its ends thereby producing enlarged homogenous strain profiles over 60% of the construct length at different physiological loading strains and frequencies, along with promoting cell viability and matrix organization within the 3D collagen constructs.
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