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Glucose‐stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets

An investigation of the effects of hydrogel encapsulation on the glucose‐stimulated insulin secretion of human islets is presented using dynamic perifusion experiments as well as computational modeling. Larger capsules dampen the first‐phase insulin response and delay the response to changes in inco... Full description

Journal Title: Biotechnology and Bioengineering January 2018, Vol.115(1), pp.232-245
Main Author: Buchwald, Peter
Other Authors: Tamayo‐Garcia, Alejandro , Manzoli, Vita , Tomei, Alice A. , Stabler, Cherie L.
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0006-3592 ; E-ISSN: 1097-0290 ; DOI: 10.1002/bit.26442
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recordid: wj10.1002/bit.26442
title: Glucose‐stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets
format: Article
creator:
  • Buchwald, Peter
  • Tamayo‐Garcia, Alejandro
  • Manzoli, Vita
  • Tomei, Alice A.
  • Stabler, Cherie L.
subjects:
  • Alginate
  • Diabetes Mellitus
  • Fem Model
  • Fluid Dynamics
  • Glucose‐Stimulated Insulin Secretion
  • Islet Encapsulation
ispartof: Biotechnology and Bioengineering, January 2018, Vol.115(1), pp.232-245
description: An investigation of the effects of hydrogel encapsulation on the glucose‐stimulated insulin secretion of human islets is presented using dynamic perifusion experiments as well as computational modeling. Larger capsules dampen the first‐phase insulin response and delay the response to changes in incoming glucose. Bioartificial pancreas type devices need to integrate immunoisolation and biocompatibility considerations with optimized nutrient diffusion and insulin release characteristics.
language:
source:
identifier: ISSN: 0006-3592 ; E-ISSN: 1097-0290 ; DOI: 10.1002/bit.26442
fulltext: fulltext
issn:
  • 0006-3592
  • 00063592
  • 1097-0290
  • 10970290
url: Link


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titleGlucose‐stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets
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descriptionAn investigation of the effects of hydrogel encapsulation on the glucose‐stimulated insulin secretion of human islets is presented using dynamic perifusion experiments as well as computational modeling. Larger capsules dampen the first‐phase insulin response and delay the response to changes in incoming glucose. Bioartificial pancreas type devices need to integrate immunoisolation and biocompatibility considerations with optimized nutrient diffusion and insulin release characteristics.
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titleGlucose‐stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets
descriptionAn investigation of the effects of hydrogel encapsulation on the glucose‐stimulated insulin secretion of human islets is presented using dynamic perifusion experiments as well as computational modeling. Larger capsules dampen the first‐phase insulin response and delay the response to changes in incoming glucose. Bioartificial pancreas type devices need to integrate immunoisolation and biocompatibility considerations with optimized nutrient diffusion and insulin release characteristics.
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titleGlucose‐stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets
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abstractAn investigation of the effects of hydrogel encapsulation on the glucose‐stimulated insulin secretion of human islets is presented using dynamic perifusion experiments as well as computational modeling. Larger capsules dampen the first‐phase insulin response and delay the response to changes in incoming glucose. Bioartificial pancreas type devices need to integrate immunoisolation and biocompatibility considerations with optimized nutrient diffusion and insulin release characteristics.
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