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Pyranonigrin E: A PKS‐NRPS Hybrid Metabolite from Aspergillus niger Identified by Genome Mining

: The genome mining approach is useful for obtaining new compounds. We activated a dormant PKS‐NRPS gene cluster in ATCC 1015 by expressing its dedicated transcriptional activator (PynR). As a result, the transformant expressing pynR produced a new pyranonigrin compound that we have named pyranonigi... Full description

Journal Title: ChemBioChem 04 November 2013, Vol.14(16), pp.2095-2099
Main Author: Awakawa, Takayoshi
Other Authors: Yang, Xiao‐Long , Wakimoto, Toshiyuki , Abe, Ikuro
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1439-4227 ; E-ISSN: 1439-7633 ; DOI: 10.1002/cbic.201300430
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recordid: wj10.1002/cbic.201300430
title: Pyranonigrin E: A PKS‐NRPS Hybrid Metabolite from Aspergillus niger Identified by Genome Mining
format: Article
creator:
  • Awakawa, Takayoshi
  • Yang, Xiao‐Long
  • Wakimoto, Toshiyuki
  • Abe, Ikuro
subjects:
  • Gene Expression
  • Genome Mining
  • Peptides
  • Polyketides
  • Transcriptional Factors
ispartof: ChemBioChem, 04 November 2013, Vol.14(16), pp.2095-2099
description: : The genome mining approach is useful for obtaining new compounds. We activated a dormant PKS‐NRPS gene cluster in ATCC 1015 by expressing its dedicated transcriptional activator (PynR). As a result, the transformant expressing pynR produced a new pyranonigrin compound that we have named pyranonigirin E.
language: eng
source:
identifier: ISSN: 1439-4227 ; E-ISSN: 1439-7633 ; DOI: 10.1002/cbic.201300430
fulltext: fulltext
issn:
  • 1439-4227
  • 14394227
  • 1439-7633
  • 14397633
url: Link


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titlePyranonigrin E: A PKS‐NRPS Hybrid Metabolite from Aspergillus niger Identified by Genome Mining
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subjectGene Expression ; Genome Mining ; Peptides ; Polyketides ; Transcriptional Factors
description: The genome mining approach is useful for obtaining new compounds. We activated a dormant PKS‐NRPS gene cluster in ATCC 1015 by expressing its dedicated transcriptional activator (PynR). As a result, the transformant expressing pynR produced a new pyranonigrin compound that we have named pyranonigirin E.
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titlePyranonigrin E: A PKS‐NRPS Hybrid Metabolite from Aspergillus niger Identified by Genome Mining
description: The genome mining approach is useful for obtaining new compounds. We activated a dormant PKS‐NRPS gene cluster in ATCC 1015 by expressing its dedicated transcriptional activator (PynR). As a result, the transformant expressing pynR produced a new pyranonigrin compound that we have named pyranonigirin E.
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abstract: The genome mining approach is useful for obtaining new compounds. We activated a dormant PKS‐NRPS gene cluster in ATCC 1015 by expressing its dedicated transcriptional activator (PynR). As a result, the transformant expressing pynR produced a new pyranonigrin compound that we have named pyranonigirin E.
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pages2095-2099
date2013-11-04