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Differential Modulating Effect of MoS2 on Amyloid Peptide Assemblies

The abnormal fibrillogenesis of amyloid peptides such as amyloid fibril and senior amyloid plaques, is associated with the pathogenesis of many amyloid diseases. Hence, modulation of amyloid assemblies is related to the possible pathogenesis of some diseases. Some two‐dimensional nanomaterials, that... Full description

Journal Title: Chemistry – A European Journal 07 March 2018, Vol.24(14), pp.3397-3402
Main Author: Wang, Jie
Other Authors: Liu, Lei , Ge, Daohan , Zhang, Hongxing , Feng, Yonghai , Zhang, Yibang , Chen, Menglin , Dong, Mingdong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0947-6539 ; E-ISSN: 1521-3765 ; DOI: 10.1002/chem.201704593
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recordid: wj10.1002/chem.201704593
title: Differential Modulating Effect of MoS2 on Amyloid Peptide Assemblies
format: Article
creator:
  • Wang, Jie
  • Liu, Lei
  • Ge, Daohan
  • Zhang, Hongxing
  • Feng, Yonghai
  • Zhang, Yibang
  • Chen, Menglin
  • Dong, Mingdong
subjects:
  • Amyloid Peptides
  • Biophysics
  • Fibrillogenesis
  • Modulating Assembly
  • Molybdenum Disulfide
ispartof: Chemistry – A European Journal, 07 March 2018, Vol.24(14), pp.3397-3402
description: The abnormal fibrillogenesis of amyloid peptides such as amyloid fibril and senior amyloid plaques, is associated with the pathogenesis of many amyloid diseases. Hence, modulation of amyloid assemblies is related to the possible pathogenesis of some diseases. Some two‐dimensional nanomaterials, that is, graphene oxide, tungsten disulfide, exhibit strong modulation effects on the amyloid fibrillogenesis. Herein, the modulation effect of molybdenum disulfide on two amyloid peptide assemblies based on the label‐free techniques is presented, including quartz crystal microbalance (QCM), AFM, and CD spectroscopy. MoS presents different modulating effects on the assembly of amyloid‐β peptide (33–42) [Aβ (33–42)] and amylin (20–29), mainly owing to the distinct affinity between amyloid peptides and MoS. This is to our knowledge the first report of MoS as a modulator for amyloid aggregation. It enriches the variety of 2D nanomodulators of amyloid fibrillogenesis and explains the mechanism for the self‐assembly of amyloid peptides, and expands the applications of MoS in biology. is capable of tuning amyloid peptide assemblies like graphene oxide. MoS has shown stronger modulating effect on the aggregation of amylin (20–29) by virtue of its amphiphilic properties.
language: eng
source:
identifier: ISSN: 0947-6539 ; E-ISSN: 1521-3765 ; DOI: 10.1002/chem.201704593
fulltext: fulltext
issn:
  • 0947-6539
  • 09476539
  • 1521-3765
  • 15213765
url: Link


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titleDifferential Modulating Effect of MoS2 on Amyloid Peptide Assemblies
creatorWang, Jie ; Liu, Lei ; Ge, Daohan ; Zhang, Hongxing ; Feng, Yonghai ; Zhang, Yibang ; Chen, Menglin ; Dong, Mingdong
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subjectAmyloid Peptides ; Biophysics ; Fibrillogenesis ; Modulating Assembly ; Molybdenum Disulfide
descriptionThe abnormal fibrillogenesis of amyloid peptides such as amyloid fibril and senior amyloid plaques, is associated with the pathogenesis of many amyloid diseases. Hence, modulation of amyloid assemblies is related to the possible pathogenesis of some diseases. Some two‐dimensional nanomaterials, that is, graphene oxide, tungsten disulfide, exhibit strong modulation effects on the amyloid fibrillogenesis. Herein, the modulation effect of molybdenum disulfide on two amyloid peptide assemblies based on the label‐free techniques is presented, including quartz crystal microbalance (QCM), AFM, and CD spectroscopy. MoS presents different modulating effects on the assembly of amyloid‐β peptide (33–42) [Aβ (33–42)] and amylin (20–29), mainly owing to the distinct affinity between amyloid peptides and MoS. This is to our knowledge the first report of MoS as a modulator for amyloid aggregation. It enriches the variety of 2D nanomodulators of amyloid fibrillogenesis and explains the mechanism for the self‐assembly of amyloid peptides, and expands the applications of MoS in biology. is capable of tuning amyloid peptide assemblies like graphene oxide. MoS has shown stronger modulating effect on the aggregation of amylin (20–29) by virtue of its amphiphilic properties.
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titleDifferential Modulating Effect of MoS2 on Amyloid Peptide Assemblies
descriptionThe abnormal fibrillogenesis of amyloid peptides such as amyloid fibril and senior amyloid plaques, is associated with the pathogenesis of many amyloid diseases. Hence, modulation of amyloid assemblies is related to the possible pathogenesis of some diseases. Some two‐dimensional nanomaterials, that is, graphene oxide, tungsten disulfide, exhibit strong modulation effects on the amyloid fibrillogenesis. Herein, the modulation effect of molybdenum disulfide on two amyloid peptide assemblies based on the label‐free techniques is presented, including quartz crystal microbalance (QCM), AFM, and CD spectroscopy. MoS presents different modulating effects on the assembly of amyloid‐β peptide (33–42) [Aβ (33–42)] and amylin (20–29), mainly owing to the distinct affinity between amyloid peptides and MoS. This is to our knowledge the first report of MoS as a modulator for amyloid aggregation. It enriches the variety of 2D nanomodulators of amyloid fibrillogenesis and explains the mechanism for the self‐assembly of amyloid peptides, and expands the applications of MoS in biology. is capable of tuning amyloid peptide assemblies like graphene oxide. MoS has shown stronger modulating effect on the aggregation of amylin (20–29) by virtue of its amphiphilic properties.
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abstractThe abnormal fibrillogenesis of amyloid peptides such as amyloid fibril and senior amyloid plaques, is associated with the pathogenesis of many amyloid diseases. Hence, modulation of amyloid assemblies is related to the possible pathogenesis of some diseases. Some two‐dimensional nanomaterials, that is, graphene oxide, tungsten disulfide, exhibit strong modulation effects on the amyloid fibrillogenesis. Herein, the modulation effect of molybdenum disulfide on two amyloid peptide assemblies based on the label‐free techniques is presented, including quartz crystal microbalance (QCM), AFM, and CD spectroscopy. MoS presents different modulating effects on the assembly of amyloid‐β peptide (33–42) [Aβ (33–42)] and amylin (20–29), mainly owing to the distinct affinity between amyloid peptides and MoS. This is to our knowledge the first report of MoS as a modulator for amyloid aggregation. It enriches the variety of 2D nanomodulators of amyloid fibrillogenesis and explains the mechanism for the self‐assembly of amyloid peptides, and expands the applications of MoS in biology. is capable of tuning amyloid peptide assemblies like graphene oxide. MoS has shown stronger modulating effect on the aggregation of amylin (20–29) by virtue of its amphiphilic properties.
doi10.1002/chem.201704593
pages3397-3402
orcididhttp://orcid.org/0000-0002-2025-2171
date2018-03-07