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Carbon Nanotubes Encapsulated in Coiled‐Coil Peptide Barrels

Specific functionalization of 1D nanomaterials such as near infrared (nIR) fluorescent single‐walled carbon nanotubes (SWCNTs) is essential for colloidal stability and tailoring of their interactions with the environment. Here, we show that de novo designed alpha‐helical coiled‐coil peptide barrels... Full description

Journal Title: Chemistry – A European Journal 22 August 2018, Vol.24(47), pp.12241-12245
Main Author: Mann, Florian A.
Other Authors: Horlebein, Jan , Meyer, Nils Frederik , Meyer, Daniel , Thomas, Franziska , Kruss, Sebastian
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0947-6539 ; E-ISSN: 1521-3765 ; DOI: 10.1002/chem.201800993
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recordid: wj10.1002/chem.201800993
title: Carbon Nanotubes Encapsulated in Coiled‐Coil Peptide Barrels
format: Article
creator:
  • Mann, Florian A.
  • Horlebein, Jan
  • Meyer, Nils Frederik
  • Meyer, Daniel
  • Thomas, Franziska
  • Kruss, Sebastian
subjects:
  • Biosensors
  • Carbon
  • Coiled Coil
  • Nanotubes
  • Peptides
ispartof: Chemistry – A European Journal, 22 August 2018, Vol.24(47), pp.12241-12245
description: Specific functionalization of 1D nanomaterials such as near infrared (nIR) fluorescent single‐walled carbon nanotubes (SWCNTs) is essential for colloidal stability and tailoring of their interactions with the environment. Here, we show that de novo designed alpha‐helical coiled‐coil peptide barrels (αHBs) with appropriate pores encapsulate and solubilize SWCNTs. In contrast, barrels without or with narrow pores showed a much smaller efficiency. Absorption/fluorescence spectroscopy and atomic force microscopy indicate that the SWCNTs are incorporated into the αHB′s pore. The resulting hybrid display periodic surface coverage with a 40 nm pitch and remain fluorescent in the nIR. This approach presents a novel concept to encapsulate, discriminate and functionalize SWCNTs non‐covalently with peptides and holds great promise for future applications in bioimaging or drug delivery. : De‐novo designed α‐helical coiled‐coil peptide barrels were used to encapsulate, solubilize and discriminate single‐walled carbon nanotubes. Different analytical techniques revealed a periodic surface‐coverage pattern. These α‐helical barrels can act as an anchoring platform for functional units around carbon nanotubes, which opens up new avenues for their application.
language: eng
source:
identifier: ISSN: 0947-6539 ; E-ISSN: 1521-3765 ; DOI: 10.1002/chem.201800993
fulltext: fulltext
issn:
  • 0947-6539
  • 09476539
  • 1521-3765
  • 15213765
url: Link


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titleCarbon Nanotubes Encapsulated in Coiled‐Coil Peptide Barrels
creatorMann, Florian A. ; Horlebein, Jan ; Meyer, Nils Frederik ; Meyer, Daniel ; Thomas, Franziska ; Kruss, Sebastian
ispartofChemistry – A European Journal, 22 August 2018, Vol.24(47), pp.12241-12245
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subjectBiosensors ; Carbon ; Coiled Coil ; Nanotubes ; Peptides
descriptionSpecific functionalization of 1D nanomaterials such as near infrared (nIR) fluorescent single‐walled carbon nanotubes (SWCNTs) is essential for colloidal stability and tailoring of their interactions with the environment. Here, we show that de novo designed alpha‐helical coiled‐coil peptide barrels (αHBs) with appropriate pores encapsulate and solubilize SWCNTs. In contrast, barrels without or with narrow pores showed a much smaller efficiency. Absorption/fluorescence spectroscopy and atomic force microscopy indicate that the SWCNTs are incorporated into the αHB′s pore. The resulting hybrid display periodic surface coverage with a 40 nm pitch and remain fluorescent in the nIR. This approach presents a novel concept to encapsulate, discriminate and functionalize SWCNTs non‐covalently with peptides and holds great promise for future applications in bioimaging or drug delivery. : De‐novo designed α‐helical coiled‐coil peptide barrels were used to encapsulate, solubilize and discriminate single‐walled carbon nanotubes. Different analytical techniques revealed a periodic surface‐coverage pattern. These α‐helical barrels can act as an anchoring platform for functional units around carbon nanotubes, which opens up new avenues for their application.
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titleCarbon Nanotubes Encapsulated in Coiled‐Coil Peptide Barrels
descriptionSpecific functionalization of 1D nanomaterials such as near infrared (nIR) fluorescent single‐walled carbon nanotubes (SWCNTs) is essential for colloidal stability and tailoring of their interactions with the environment. Here, we show that de novo designed alpha‐helical coiled‐coil peptide barrels (αHBs) with appropriate pores encapsulate and solubilize SWCNTs. In contrast, barrels without or with narrow pores showed a much smaller efficiency. Absorption/fluorescence spectroscopy and atomic force microscopy indicate that the SWCNTs are incorporated into the αHB′s pore. The resulting hybrid display periodic surface coverage with a 40 nm pitch and remain fluorescent in the nIR. This approach presents a novel concept to encapsulate, discriminate and functionalize SWCNTs non‐covalently with peptides and holds great promise for future applications in bioimaging or drug delivery. : De‐novo designed α‐helical coiled‐coil peptide barrels were used to encapsulate, solubilize and discriminate single‐walled carbon nanotubes. Different analytical techniques revealed a periodic surface‐coverage pattern. These α‐helical barrels can act as an anchoring platform for functional units around carbon nanotubes, which opens up new avenues for their application.
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abstractSpecific functionalization of 1D nanomaterials such as near infrared (nIR) fluorescent single‐walled carbon nanotubes (SWCNTs) is essential for colloidal stability and tailoring of their interactions with the environment. Here, we show that de novo designed alpha‐helical coiled‐coil peptide barrels (αHBs) with appropriate pores encapsulate and solubilize SWCNTs. In contrast, barrels without or with narrow pores showed a much smaller efficiency. Absorption/fluorescence spectroscopy and atomic force microscopy indicate that the SWCNTs are incorporated into the αHB′s pore. The resulting hybrid display periodic surface coverage with a 40 nm pitch and remain fluorescent in the nIR. This approach presents a novel concept to encapsulate, discriminate and functionalize SWCNTs non‐covalently with peptides and holds great promise for future applications in bioimaging or drug delivery. : De‐novo designed α‐helical coiled‐coil peptide barrels were used to encapsulate, solubilize and discriminate single‐walled carbon nanotubes. Different analytical techniques revealed a periodic surface‐coverage pattern. These α‐helical barrels can act as an anchoring platform for functional units around carbon nanotubes, which opens up new avenues for their application.
doi10.1002/chem.201800993
orcidid0000-0003-2348-1663
pages12241-12245
date2018-08-22