schliessen

Filtern

 

Bibliotheken

Long‐term follow‐up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas

BACKGROUND: Patients with large, high-grade, extremity soft tissue sarcomas (STS) are at significant risk for distant recurrence and death. A regimen of preoperative chemotherapy consisting of mesna, Adriamycin (doxorubicin), ifosfamide, and dacarbazine (MAID), interdigitated with radiotherapy (RT)... Full description

Journal Title: Cancer 01 August 2012, Vol.118(15), pp.3758-3765
Main Author: Mullen, John T.
Other Authors: Kobayashi, Wendy , Wang, Jing Jing , Harmon, David C. , Choy, Edwin , Hornicek, Francis J. , Rosenberg, Andrew E. , Chen, Yen‐Lin , Spiro, Ira J. , Delaney, Thomas F.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0008-543X ; E-ISSN: 1097-0142 ; DOI: 10.1002/cncr.26696
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: wj10.1002/cncr.26696
title: Long‐term follow‐up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas
format: Article
creator:
  • Mullen, John T.
  • Kobayashi, Wendy
  • Wang, Jing Jing
  • Harmon, David C.
  • Choy, Edwin
  • Hornicek, Francis J.
  • Rosenberg, Andrew E.
  • Chen, Yen‐Lin
  • Spiro, Ira J.
  • Delaney, Thomas F.
subjects:
  • Soft Tissue Sarcoma
  • Neoadjuvant Chemotherapy
  • Radiotherapy
  • Follow‐Up
  • Extremity Sarcoma
  • Mesna
  • Adriamycin Doxorubicin
  • Ifosfamide
  • And Dacarbazine Maid
ispartof: Cancer, 01 August 2012, Vol.118(15), pp.3758-3765
description: BACKGROUND: Patients with large, high-grade, extremity soft tissue sarcomas (STS) are at significant risk for distant recurrence and death. A regimen of preoperative chemotherapy consisting of mesna, Adriamycin (doxorubicin), ifosfamide, and dacarbazine (MAID), interdigitated with radiotherapy (RT) and followed by resection and postoperative chemotherapy with or without RT, has demonstrated high rates of local and distant control. We report the long-term follow-up data on 48 patients treated with this regimen compared to an historical matched-control patient population. METHODS: Adult patients with high-grade extremity STS greater than or equal to 8 cm were treated with 3 cycles of preoperative chemotherapy combined with 44 Gy of RT followed by surgery. Three cycles of postoperative MAID were planned. For patients with positive surgical margins, 16 Gy of RT was delivered postoperatively. RESULTS: Patients received the MAID/RT regimen from 1989 through 1999. After a median follow-up of 9.3 years in surviving patients in the MAID group and 13.2 years in surviving patients in the control group, the 7-year disease-specific and overall survival rates were 81% and 50% (P = .004) and 79% and 45% (P = .003) for the MAID and control patients, respectively. Five of 11 patients in the MAID group and 7 of 25 control patients died of sarcoma greater than or equal to 5 years after treatment. One patient in the MAID group developed a fatal myelodysplasia at 53 months. CONCLUSIONS: For patients with high-risk, extremity STS, the significant survival benefits conferred by an intense regimen of neoadjuvant chemoradiotherapy and surgery are sustained even with long-term follow-up. Cancer 2012. copyright 2011 American Cancer Society. For patients with high-risk, extremity soft tissue sarcoma, the significant survival benefits conferred by an intense regimen of neoadjuvant chemoradiotherapy and surgery are sustained even with long-term follow-up, despite the fact that sarcoma-related deaths continue to occur well beyond 5 years.
language: eng
source:
identifier: ISSN: 0008-543X ; E-ISSN: 1097-0142 ; DOI: 10.1002/cncr.26696
fulltext: fulltext
issn:
  • 0008-543X
  • 0008543X
  • 1097-0142
  • 10970142
url: Link


@attributes
ID633826052
RANK0.06999999
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1002/cncr.26696
sourceidwj
recordidTN_wj10.1002/cncr.26696
sourcesystemPC
pqid1562665137
galeid298998966
display
typearticle
titleLong‐term follow‐up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas
creatorMullen, John T. ; Kobayashi, Wendy ; Wang, Jing Jing ; Harmon, David C. ; Choy, Edwin ; Hornicek, Francis J. ; Rosenberg, Andrew E. ; Chen, Yen‐Lin ; Spiro, Ira J. ; Delaney, Thomas F.
ispartofCancer, 01 August 2012, Vol.118(15), pp.3758-3765
identifier
subjectSoft Tissue Sarcoma ; Neoadjuvant Chemotherapy ; Radiotherapy ; Follow‐Up ; Extremity Sarcoma ; Mesna ; Adriamycin Doxorubicin ; Ifosfamide ; And Dacarbazine Maid
languageeng
source
descriptionBACKGROUND: Patients with large, high-grade, extremity soft tissue sarcomas (STS) are at significant risk for distant recurrence and death. A regimen of preoperative chemotherapy consisting of mesna, Adriamycin (doxorubicin), ifosfamide, and dacarbazine (MAID), interdigitated with radiotherapy (RT) and followed by resection and postoperative chemotherapy with or without RT, has demonstrated high rates of local and distant control. We report the long-term follow-up data on 48 patients treated with this regimen compared to an historical matched-control patient population. METHODS: Adult patients with high-grade extremity STS greater than or equal to 8 cm were treated with 3 cycles of preoperative chemotherapy combined with 44 Gy of RT followed by surgery. Three cycles of postoperative MAID were planned. For patients with positive surgical margins, 16 Gy of RT was delivered postoperatively. RESULTS: Patients received the MAID/RT regimen from 1989 through 1999. After a median follow-up of 9.3 years in surviving patients in the MAID group and 13.2 years in surviving patients in the control group, the 7-year disease-specific and overall survival rates were 81% and 50% (P = .004) and 79% and 45% (P = .003) for the MAID and control patients, respectively. Five of 11 patients in the MAID group and 7 of 25 control patients died of sarcoma greater than or equal to 5 years after treatment. One patient in the MAID group developed a fatal myelodysplasia at 53 months. CONCLUSIONS: For patients with high-risk, extremity STS, the significant survival benefits conferred by an intense regimen of neoadjuvant chemoradiotherapy and surgery are sustained even with long-term follow-up. Cancer 2012. copyright 2011 American Cancer Society. For patients with high-risk, extremity soft tissue sarcoma, the significant survival benefits conferred by an intense regimen of neoadjuvant chemoradiotherapy and surgery are sustained even with long-term follow-up, despite the fact that sarcoma-related deaths continue to occur well beyond 5 years.
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Mullen, John T.
1Kobayashi, Wendy
2Wang, Jing Jing
3Harmon, David C.
4Choy, Edwin
5Hornicek, Francis J.
6Rosenberg, Andrew E.
7Chen, Yen‐Lin
8Spiro, Ira J.
9Delaney, Thomas F.
titleLong‐term follow‐up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas
subject
0Soft Tissue Sarcoma
1Neoadjuvant Chemotherapy
2Radiotherapy
3Follow‐Up
4Extremity Sarcoma
5Mesna
6Adriamycin Doxorubicin
7Ifosfamide
8And Dacarbazine Maid
general
0English
1Wiley Subscription Services, Inc., A Wiley Company
210.1002/cncr.26696
3Wiley Online Library
sourceidwj
recordidwj10.1002/cncr.26696
issn
00008-543X
10008543X
21097-0142
310970142
rsrctypearticle
creationdate2012
addtitleCancer
searchscope
0wj
1wiley
scope
0wj
1wiley
lsr30VSR-Enriched:[description, pages, pqid, galeid]
sort
titleLong‐term follow‐up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas
authorMullen, John T. ; Kobayashi, Wendy ; Wang, Jing Jing ; Harmon, David C. ; Choy, Edwin ; Hornicek, Francis J. ; Rosenberg, Andrew E. ; Chen, Yen‐Lin ; Spiro, Ira J. ; Delaney, Thomas F.
creationdate20120801
facets
frbrgroupid8127754146065156697
frbrtype5
languageeng
creationdate2012
topic
0Soft Tissue Sarcoma
1Neoadjuvant Chemotherapy
2Radiotherapy
3Follow‐Up
4Extremity Sarcoma
5Mesna
6Adriamycin Doxorubicin
7Ifosfamide
8And Dacarbazine Maid
collectionWiley Online Library
prefilterarticles
rsrctypearticles
creatorcontrib
0Mullen, John T.
1Kobayashi, Wendy
2Wang, Jing Jing
3Harmon, David C.
4Choy, Edwin
5Hornicek, Francis J.
6Rosenberg, Andrew E.
7Chen, Yen‐Lin
8Spiro, Ira J.
9Delaney, Thomas F.
jtitleCancer
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Mullen
1Kobayashi
2Wang
3Harmon
4Choy
5Hornicek
6Rosenberg
7Chen
8Spiro
9DeLaney
aufirst
0John T.
1Wendy
2Jing Jing
3David C.
4Edwin
5Francis J.
6Andrew E.
7Yen‐Lin
8Ira J.
9Thomas F.
au
0Mullen, John T.
1Kobayashi, Wendy
2Wang, Jing Jing
3Harmon, David C.
4Choy, Edwin
5Hornicek, Francis J.
6Rosenberg, Andrew E.
7Chen, Yen‐Lin
8Spiro, Ira J.
9Delaney, Thomas F.
atitleLong‐term follow‐up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas
jtitleCancer
risdate20120801
volume118
issue15
spage3758
epage3765
issn0008-543X
eissn1097-0142
genrearticle
ristypeJOUR
copHoboken
pubWiley Subscription Services, Inc., A Wiley Company
doi10.1002/cncr.26696
pages3758-3765
date2012-08-01