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Multi‐omics approach to elucidate the gut microbiota activity: Metaproteomics and metagenomics connection

Over the last few years, the application of high‐throughput meta‐omics methods has provided great progress in improving the knowledge of the gut ecosystem and linking its biodiversity to host health conditions, offering complementary support to classical microbiology. Gut microbiota plays a crucial... Full description

Journal Title: ELECTROPHORESIS July 2018, Vol.39(13), pp.1692-1701
Main Author: Guirro, Maria
Other Authors: Costa, Andrea , Gual‐Grau, Andreu , Mayneris‐Perxachs, Jordi , Torrell, Helena , Herrero, Pol , Canela, Núria , Arola, Lluís
Format: Electronic Article Electronic Article
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ID: ISSN: 0173-0835 ; E-ISSN: 1522-2683 ; DOI: 10.1002/elps.201700476
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recordid: wj10.1002/elps.201700476
title: Multi‐omics approach to elucidate the gut microbiota activity: Metaproteomics and metagenomics connection
format: Article
creator:
  • Guirro, Maria
  • Costa, Andrea
  • Gual‐Grau, Andreu
  • Mayneris‐Perxachs, Jordi
  • Torrell, Helena
  • Herrero, Pol
  • Canela, Núria
  • Arola, Lluís
subjects:
  • Hesperidin
  • Metagenomics
  • Metaproteomics
  • Microbiota
ispartof: ELECTROPHORESIS, July 2018, Vol.39(13), pp.1692-1701
description: Over the last few years, the application of high‐throughput meta‐omics methods has provided great progress in improving the knowledge of the gut ecosystem and linking its biodiversity to host health conditions, offering complementary support to classical microbiology. Gut microbiota plays a crucial role in relevant diseases such as obesity or cardiovascular disease (CVD), and its regulation is closely influenced by several factors, such as dietary composition. In fact, polyphenol‐rich diets are the most palatable treatment to prevent hypertension associated with CVD, although the polyphenol–microbiota interactions have not been completely elucidated. For this reason, the aim of this study was to evaluate microbiota effect in obese rats supplemented by hesperidin, after being fed with cafeteria or standard diet, using a multi meta‐omics approaches combining strategy of metagenomics and metaproteomics analysis. We reported that cafeteria diet induces obesity, resulting in changes in the microbiota composition, which are related to functional alterations at proteome level. In addition, hesperidin supplementation alters microbiota diversity and also proteins involved in important metabolic pathways. Overall, going deeper into strategies to integrate omics sciences is necessary to understand the complex relationships between the host, gut microbiota, and diet.
language:
source:
identifier: ISSN: 0173-0835 ; E-ISSN: 1522-2683 ; DOI: 10.1002/elps.201700476
fulltext: fulltext
issn:
  • 0173-0835
  • 01730835
  • 1522-2683
  • 15222683
url: Link


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titleMulti‐omics approach to elucidate the gut microbiota activity: Metaproteomics and metagenomics connection
creatorGuirro, Maria ; Costa, Andrea ; Gual‐Grau, Andreu ; Mayneris‐Perxachs, Jordi ; Torrell, Helena ; Herrero, Pol ; Canela, Núria ; Arola, Lluís
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subjectHesperidin ; Metagenomics ; Metaproteomics ; Microbiota
descriptionOver the last few years, the application of high‐throughput meta‐omics methods has provided great progress in improving the knowledge of the gut ecosystem and linking its biodiversity to host health conditions, offering complementary support to classical microbiology. Gut microbiota plays a crucial role in relevant diseases such as obesity or cardiovascular disease (CVD), and its regulation is closely influenced by several factors, such as dietary composition. In fact, polyphenol‐rich diets are the most palatable treatment to prevent hypertension associated with CVD, although the polyphenol–microbiota interactions have not been completely elucidated. For this reason, the aim of this study was to evaluate microbiota effect in obese rats supplemented by hesperidin, after being fed with cafeteria or standard diet, using a multi meta‐omics approaches combining strategy of metagenomics and metaproteomics analysis. We reported that cafeteria diet induces obesity, resulting in changes in the microbiota composition, which are related to functional alterations at proteome level. In addition, hesperidin supplementation alters microbiota diversity and also proteins involved in important metabolic pathways. Overall, going deeper into strategies to integrate omics sciences is necessary to understand the complex relationships between the host, gut microbiota, and diet.
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titleMulti‐omics approach to elucidate the gut microbiota activity: Metaproteomics and metagenomics connection
authorGuirro, Maria ; Costa, Andrea ; Gual‐Grau, Andreu ; Mayneris‐Perxachs, Jordi ; Torrell, Helena ; Herrero, Pol ; Canela, Núria ; Arola, Lluís
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abstractOver the last few years, the application of high‐throughput meta‐omics methods has provided great progress in improving the knowledge of the gut ecosystem and linking its biodiversity to host health conditions, offering complementary support to classical microbiology. Gut microbiota plays a crucial role in relevant diseases such as obesity or cardiovascular disease (CVD), and its regulation is closely influenced by several factors, such as dietary composition. In fact, polyphenol‐rich diets are the most palatable treatment to prevent hypertension associated with CVD, although the polyphenol–microbiota interactions have not been completely elucidated. For this reason, the aim of this study was to evaluate microbiota effect in obese rats supplemented by hesperidin, after being fed with cafeteria or standard diet, using a multi meta‐omics approaches combining strategy of metagenomics and metaproteomics analysis. We reported that cafeteria diet induces obesity, resulting in changes in the microbiota composition, which are related to functional alterations at proteome level. In addition, hesperidin supplementation alters microbiota diversity and also proteins involved in important metabolic pathways. Overall, going deeper into strategies to integrate omics sciences is necessary to understand the complex relationships between the host, gut microbiota, and diet.
doi10.1002/elps.201700476
pages1692-1701
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date2018-07