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Suppression of humoral immune responses by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin intercalated in smectite clay

2,3,7,8‐Tetrachlorodibenzo‐‐dioxin (TCDD) is a highly toxic environmental contaminant found in soils and sediments. Because of its exceptionally low water solubility, this compound exists predominantly in the sorbed state in natural environments. Clay minerals, especially expandable smectite clays,... Full description

Journal Title: Environmental Toxicology and Chemistry December 2011, Vol.30(12), pp.2748-2755
Main Author: Boyd, Stephen A.
Other Authors: Johnston, Cliff T. , Pinnavaia, Thomas J. , Kaminski, Norbert E. , Teppen, Brian J. , Li, Hui , Khan, Bushra , Crawford, Robert B. , Kovalova, Natalia , Kim, Seong‐Su , Shao, Hua , Gu, Cheng , Kaplan, Barbara L. F.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0730-7268 ; E-ISSN: 1552-8618 ; DOI: 10.1002/etc.701
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recordid: wj10.1002/etc.701
title: Suppression of humoral immune responses by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin intercalated in smectite clay
format: Article
creator:
  • Boyd, Stephen A.
  • Johnston, Cliff T.
  • Pinnavaia, Thomas J.
  • Kaminski, Norbert E.
  • Teppen, Brian J.
  • Li, Hui
  • Khan, Bushra
  • Crawford, Robert B.
  • Kovalova, Natalia
  • Kim, Seong‐Su
  • Shao, Hua
  • Gu, Cheng
  • Kaplan, Barbara L. F.
subjects:
  • Sorption
  • Bioavailability
  • Dioxin
  • Clay Mineral
  • Soil Toxicology
ispartof: Environmental Toxicology and Chemistry, December 2011, Vol.30(12), pp.2748-2755
description: 2,3,7,8‐Tetrachlorodibenzo‐‐dioxin (TCDD) is a highly toxic environmental contaminant found in soils and sediments. Because of its exceptionally low water solubility, this compound exists predominantly in the sorbed state in natural environments. Clay minerals, especially expandable smectite clays, are one of the major component geosorbents in soils and sediments that can function as an effective adsorbent for environmental dioxins, including TCDD. In this study, TCDD was intercalated in the smectite clay saponite by an incipient wetness method. The primary goal of this study was to intercalate TCDD in natural K‐saponite clay and evaluate its immunotoxic effects in vivo. The relative bioavailability of TCDD was evaluated by comparing the metabolic activity of TCDD administered in the adsorbed state as an intercalate in saponite and freely dissolved in corn oil. This comparison revealed nearly identical TCDD‐induced suppression of humoral immunity, a well‐established and sensitive sequela, in a mammalian (mouse) model. This result suggests that TCDD adsorbed by clays is likely to be available for biouptake and biodistribution in mammals, consistent with previous observations of TCDD in livestock exposed to dioxin‐contaminated ball clays that were used as feed additives. Adsorption of TCDD by clay minerals does not appear to mitigate risk associated with TCDD exposure substantially. Environ. Toxicol. Chem. 2011;30:2748–2755. © 2011 SETAC
language: eng
source:
identifier: ISSN: 0730-7268 ; E-ISSN: 1552-8618 ; DOI: 10.1002/etc.701
fulltext: fulltext
issn:
  • 0730-7268
  • 07307268
  • 1552-8618
  • 15528618
url: Link


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titleSuppression of humoral immune responses by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin intercalated in smectite clay
creatorBoyd, Stephen A. ; Johnston, Cliff T. ; Pinnavaia, Thomas J. ; Kaminski, Norbert E. ; Teppen, Brian J. ; Li, Hui ; Khan, Bushra ; Crawford, Robert B. ; Kovalova, Natalia ; Kim, Seong‐Su ; Shao, Hua ; Gu, Cheng ; Kaplan, Barbara L. F.
ispartofEnvironmental Toxicology and Chemistry, December 2011, Vol.30(12), pp.2748-2755
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subjectSorption ; Bioavailability ; Dioxin ; Clay Mineral ; Soil Toxicology
description2,3,7,8‐Tetrachlorodibenzo‐‐dioxin (TCDD) is a highly toxic environmental contaminant found in soils and sediments. Because of its exceptionally low water solubility, this compound exists predominantly in the sorbed state in natural environments. Clay minerals, especially expandable smectite clays, are one of the major component geosorbents in soils and sediments that can function as an effective adsorbent for environmental dioxins, including TCDD. In this study, TCDD was intercalated in the smectite clay saponite by an incipient wetness method. The primary goal of this study was to intercalate TCDD in natural K‐saponite clay and evaluate its immunotoxic effects in vivo. The relative bioavailability of TCDD was evaluated by comparing the metabolic activity of TCDD administered in the adsorbed state as an intercalate in saponite and freely dissolved in corn oil. This comparison revealed nearly identical TCDD‐induced suppression of humoral immunity, a well‐established and sensitive sequela, in a mammalian (mouse) model. This result suggests that TCDD adsorbed by clays is likely to be available for biouptake and biodistribution in mammals, consistent with previous observations of TCDD in livestock exposed to dioxin‐contaminated ball clays that were used as feed additives. Adsorption of TCDD by clay minerals does not appear to mitigate risk associated with TCDD exposure substantially. Environ. Toxicol. Chem. 2011;30:2748–2755. © 2011 SETAC
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titleSuppression of humoral immune responses by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin intercalated in smectite clay
description2,3,7,8‐Tetrachlorodibenzo‐‐dioxin (TCDD) is a highly toxic environmental contaminant found in soils and sediments. Because of its exceptionally low water solubility, this compound exists predominantly in the sorbed state in natural environments. Clay minerals, especially expandable smectite clays, are one of the major component geosorbents in soils and sediments that can function as an effective adsorbent for environmental dioxins, including TCDD. In this study, TCDD was intercalated in the smectite clay saponite by an incipient wetness method. The primary goal of this study was to intercalate TCDD in natural K‐saponite clay and evaluate its immunotoxic effects in vivo. The relative bioavailability of TCDD was evaluated by comparing the metabolic activity of TCDD administered in the adsorbed state as an intercalate in saponite and freely dissolved in corn oil. This comparison revealed nearly identical TCDD‐induced suppression of humoral immunity, a well‐established and sensitive sequela, in a mammalian (mouse) model. This result suggests that TCDD adsorbed by clays is likely to be available for biouptake and biodistribution in mammals, consistent with previous observations of TCDD in livestock exposed to dioxin‐contaminated ball clays that were used as feed additives. Adsorption of TCDD by clay minerals does not appear to mitigate risk associated with TCDD exposure substantially. Environ. Toxicol. Chem. 2011;30:2748–2755. © 2011 SETAC
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atitleSuppression of humoral immune responses by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin intercalated in smectite clay
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abstract2,3,7,8‐Tetrachlorodibenzo‐‐dioxin (TCDD) is a highly toxic environmental contaminant found in soils and sediments. Because of its exceptionally low water solubility, this compound exists predominantly in the sorbed state in natural environments. Clay minerals, especially expandable smectite clays, are one of the major component geosorbents in soils and sediments that can function as an effective adsorbent for environmental dioxins, including TCDD. In this study, TCDD was intercalated in the smectite clay saponite by an incipient wetness method. The primary goal of this study was to intercalate TCDD in natural K‐saponite clay and evaluate its immunotoxic effects in vivo. The relative bioavailability of TCDD was evaluated by comparing the metabolic activity of TCDD administered in the adsorbed state as an intercalate in saponite and freely dissolved in corn oil. This comparison revealed nearly identical TCDD‐induced suppression of humoral immunity, a well‐established and sensitive sequela, in a mammalian (mouse) model. This result suggests that TCDD adsorbed by clays is likely to be available for biouptake and biodistribution in mammals, consistent with previous observations of TCDD in livestock exposed to dioxin‐contaminated ball clays that were used as feed additives. Adsorption of TCDD by clay minerals does not appear to mitigate risk associated with TCDD exposure substantially. Environ. Toxicol. Chem. 2011;30:2748–2755. © 2011 SETAC
copHoboken, USA
pubJohn Wiley & Sons, Inc.
doi10.1002/etc.701
pages2748-2755
date2011-12