schliessen

Filtern

 

Bibliotheken

Combining tract‐ and atlas‐based analysis reveals microstructural abnormalities in early Tourette syndrome children

Tourette syndrome (TS) is a neurological disorder that causes uncontrolled repetitive motor and vocal tics in children. Examining the neural basis of TS churned out different research studies that advanced our understanding of the brain pathways involved in its development. Particularly, growing evi... Full description

Journal Title: Human Brain Mapping May 2016, Vol.37(5), pp.1903-1919
Main Author: Wen, Hongwei
Other Authors: Liu, Yue , Wang, Jieqiong , Rekik, Islem , Zhang, Jishui , Zhang, Yue , Tian, Hongwei , Peng, Yun , He, Huiguang
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 1065-9471 ; E-ISSN: 1097-0193 ; DOI: 10.1002/hbm.23146
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: wj10.1002/hbm.23146
title: Combining tract‐ and atlas‐based analysis reveals microstructural abnormalities in early Tourette syndrome children
format: Article
creator:
  • Wen, Hongwei
  • Liu, Yue
  • Wang, Jieqiong
  • Rekik, Islem
  • Zhang, Jishui
  • Zhang, Yue
  • Tian, Hongwei
  • Peng, Yun
  • He, Huiguang
subjects:
  • Tourette Syndrome
  • Tract‐Based Spatial Statistics
  • Atlas‐Based Roi Analysis
  • Large Deformation Diffeomorphic Metric Mapping
  • Superficial White Matter
ispartof: Human Brain Mapping, May 2016, Vol.37(5), pp.1903-1919
description: Tourette syndrome (TS) is a neurological disorder that causes uncontrolled repetitive motor and vocal tics in children. Examining the neural basis of TS churned out different research studies that advanced our understanding of the brain pathways involved in its development. Particularly, growing evidence points to abnormalities within the fronto‐striato‐thalamic pathways. In this study, we combined Tract‐Based Spatial Statistics (TBSS) and Atlas‐based regions of interest (ROI) analysis approach, to investigate the microstructural diffusion changes in both deep and superficial white matter (SWM) in TS children. We then characterized the altered microstructure of white matter in 27 TS children in comparison with 27 age‐ and gender‐matched healthy controls. We found that fractional anisotropy (FA) decreases and radial diffusivity (RD) increases in deep white matter (DWM) tracts in cortico‐striato‐thalamo‐cortical (CSTC) circuit as well as SWM. Furthermore, we found that lower FA values and higher RD values in white matter regions are correlated with more severe tics, but not tics duration. Besides, we also found both axial diffusivity and mean diffusivity increase using Atlas‐based ROI analysis. Our work may suggest that microstructural diffusion changes in white matter is not only restricted to the gray matter of CSTC circuit but also affects SWM within the primary motor and somatosensory cortex, commissural and association fibers. . ©
language:
source:
identifier: ISSN: 1065-9471 ; E-ISSN: 1097-0193 ; DOI: 10.1002/hbm.23146
fulltext: fulltext
issn:
  • 1065-9471
  • 10659471
  • 1097-0193
  • 10970193
url: Link


@attributes
ID1829220875
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1002/hbm.23146
sourceidwj
recordidTN_wj10.1002/hbm.23146
sourcesystemPC
pqid1782214676
galeid449830221
display
typearticle
titleCombining tract‐ and atlas‐based analysis reveals microstructural abnormalities in early Tourette syndrome children
creatorWen, Hongwei ; Liu, Yue ; Wang, Jieqiong ; Rekik, Islem ; Zhang, Jishui ; Zhang, Yue ; Tian, Hongwei ; Peng, Yun ; He, Huiguang
ispartofHuman Brain Mapping, May 2016, Vol.37(5), pp.1903-1919
identifier
subjectTourette Syndrome ; Tract‐Based Spatial Statistics ; Atlas‐Based Roi Analysis ; Large Deformation Diffeomorphic Metric Mapping ; Superficial White Matter
descriptionTourette syndrome (TS) is a neurological disorder that causes uncontrolled repetitive motor and vocal tics in children. Examining the neural basis of TS churned out different research studies that advanced our understanding of the brain pathways involved in its development. Particularly, growing evidence points to abnormalities within the fronto‐striato‐thalamic pathways. In this study, we combined Tract‐Based Spatial Statistics (TBSS) and Atlas‐based regions of interest (ROI) analysis approach, to investigate the microstructural diffusion changes in both deep and superficial white matter (SWM) in TS children. We then characterized the altered microstructure of white matter in 27 TS children in comparison with 27 age‐ and gender‐matched healthy controls. We found that fractional anisotropy (FA) decreases and radial diffusivity (RD) increases in deep white matter (DWM) tracts in cortico‐striato‐thalamo‐cortical (CSTC) circuit as well as SWM. Furthermore, we found that lower FA values and higher RD values in white matter regions are correlated with more severe tics, but not tics duration. Besides, we also found both axial diffusivity and mean diffusivity increase using Atlas‐based ROI analysis. Our work may suggest that microstructural diffusion changes in white matter is not only restricted to the gray matter of CSTC circuit but also affects SWM within the primary motor and somatosensory cortex, commissural and association fibers. . ©
source
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Wen, Hongwei
1Liu, Yue
2Wang, Jieqiong
3Rekik, Islem
4Zhang, Jishui
5Zhang, Yue
6Tian, Hongwei
7Peng, Yun
8He, Huiguang
titleCombining tract‐ and atlas‐based analysis reveals microstructural abnormalities in early Tourette syndrome children
descriptionTourette syndrome (TS) is a neurological disorder that causes uncontrolled repetitive motor and vocal tics in children. Examining the neural basis of TS churned out different research studies that advanced our understanding of the brain pathways involved in its development. Particularly, growing evidence points to abnormalities within the fronto‐striato‐thalamic pathways. In this study, we combined Tract‐Based Spatial Statistics (TBSS) and Atlas‐based regions of interest (ROI) analysis approach, to investigate the microstructural diffusion changes in both deep and superficial white matter (SWM) in TS children. We then characterized the altered microstructure of white matter in 27 TS children in comparison with 27 age‐ and gender‐matched healthy controls. We found that fractional anisotropy (FA) decreases and radial diffusivity (RD) increases in deep white matter (DWM) tracts in cortico‐striato‐thalamo‐cortical (CSTC) circuit as well as SWM. Furthermore, we found that lower FA values and higher RD values in white matter regions are correlated with more severe tics, but not tics duration. Besides, we also found both axial diffusivity and mean diffusivity increase using Atlas‐based ROI analysis. Our work may suggest that microstructural diffusion changes in white matter is not only restricted to the gray matter of CSTC circuit but also affects SWM within the primary motor and somatosensory cortex, commissural and association fibers. . ©
subject
0Tourette Syndrome
1Tract‐Based Spatial Statistics
2Atlas‐Based Roi Analysis
3Large Deformation Diffeomorphic Metric Mapping
4Superficial White Matter
general
010.1002/hbm.23146
1Wiley Online Library
sourceidwj
recordidwj10.1002/hbm.23146
issn
01065-9471
110659471
21097-0193
310970193
rsrctypearticle
creationdate2016
addtitle
0Human Brain Mapping
1Hum. Brain Mapp.
searchscope
0wj
1wiley
scope
0wj
1wiley
lsr30VSR-Enriched:[pqid, galeid, pages, date]
sort
titleCombining tract‐ and atlas‐based analysis reveals microstructural abnormalities in early Tourette syndrome children
authorWen, Hongwei ; Liu, Yue ; Wang, Jieqiong ; Rekik, Islem ; Zhang, Jishui ; Zhang, Yue ; Tian, Hongwei ; Peng, Yun ; He, Huiguang
creationdate20160500
facets
frbrgroupid8466429445071718537
frbrtype5
creationdate2016
topic
0Tourette Syndrome
1Tract‐Based Spatial Statistics
2Atlas‐Based Roi Analysis
3Large Deformation Diffeomorphic Metric Mapping
4Superficial White Matter
collectionWiley Online Library
prefilterarticles
rsrctypearticles
creatorcontrib
0Wen, Hongwei
1Liu, Yue
2Wang, Jieqiong
3Rekik, Islem
4Zhang, Jishui
5Zhang, Yue
6Tian, Hongwei
7Peng, Yun
8He, Huiguang
jtitleHuman Brain Mapping
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Wen
1Liu
2Wang
3Rekik
4Zhang
5Tian
6Peng
7He
aufirst
0Hongwei
1Yue
2Jieqiong
3Islem
4Jishui
5Yun
6Huiguang
au
0Wen, Hongwei
1Liu, Yue
2Wang, Jieqiong
3Rekik, Islem
4Zhang, Jishui
5Zhang, Yue
6Tian, Hongwei
7Peng, Yun
8He, Huiguang
atitleCombining tract‐ and atlas‐based analysis reveals microstructural abnormalities in early Tourette syndrome children
jtitleHuman Brain Mapping
risdate201605
volume37
issue5
spage1903
epage1919
issn1065-9471
eissn1097-0193
genrearticle
ristypeJOUR
abstractTourette syndrome (TS) is a neurological disorder that causes uncontrolled repetitive motor and vocal tics in children. Examining the neural basis of TS churned out different research studies that advanced our understanding of the brain pathways involved in its development. Particularly, growing evidence points to abnormalities within the fronto‐striato‐thalamic pathways. In this study, we combined Tract‐Based Spatial Statistics (TBSS) and Atlas‐based regions of interest (ROI) analysis approach, to investigate the microstructural diffusion changes in both deep and superficial white matter (SWM) in TS children. We then characterized the altered microstructure of white matter in 27 TS children in comparison with 27 age‐ and gender‐matched healthy controls. We found that fractional anisotropy (FA) decreases and radial diffusivity (RD) increases in deep white matter (DWM) tracts in cortico‐striato‐thalamo‐cortical (CSTC) circuit as well as SWM. Furthermore, we found that lower FA values and higher RD values in white matter regions are correlated with more severe tics, but not tics duration. Besides, we also found both axial diffusivity and mean diffusivity increase using Atlas‐based ROI analysis. Our work may suggest that microstructural diffusion changes in white matter is not only restricted to the gray matter of CSTC circuit but also affects SWM within the primary motor and somatosensory cortex, commissural and association fibers. . ©
doi10.1002/hbm.23146
pages1903-1919
date2016-05-01