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FGFR2 intronic SNPs and breast cancer risk: Associations with tumor characteristics and interactions with exogenous exposures and other known breast cancer risk factors

Recent genome‐wide association studies have revealed several new candidate genes for breast cancer, including fibroblast growth factor receptor 2 () gene. The associations were also replicated in several other independent studies. The next important step is to study whether these common variants int... Full description

Journal Title: International Journal of Cancer 01 August 2011, Vol.129(3), pp.702-712
Main Author: Marian, Catalin
Other Authors: Ochs‐Balcom, Heather M. , Nie, Jing , Kallakury, Bhaskar V. , Ambrosone, Christine B. , Trevisan, Maurizio , Edge, Stephen , Shields, Peter G. , Freudenheim, Jo L.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0020-7136 ; E-ISSN: 1097-0215 ; DOI: 10.1002/ijc.25686
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recordid: wj10.1002/ijc.25686
title: FGFR2 intronic SNPs and breast cancer risk: Associations with tumor characteristics and interactions with exogenous exposures and other known breast cancer risk factors
format: Article
creator:
  • Marian, Catalin
  • Ochs‐Balcom, Heather M.
  • Nie, Jing
  • Kallakury, Bhaskar V.
  • Ambrosone, Christine B.
  • Trevisan, Maurizio
  • Edge, Stephen
  • Shields, Peter G.
  • Freudenheim, Jo L.
subjects:
  • Breast Cancer
  • Fgfr2
  • Gene–Environment Interactions
ispartof: International Journal of Cancer, 01 August 2011, Vol.129(3), pp.702-712
description: Recent genome‐wide association studies have revealed several new candidate genes for breast cancer, including fibroblast growth factor receptor 2 () gene. The associations were also replicated in several other independent studies. The next important step is to study whether these common variants interact with known breast cancer risk factors, exogenous exposures and tumor characteristics. In a population‐based case–control study of 1,170 breast cancer cases and 2,115 controls, we examined genetic associations of four intronic single‐nucleotide polymorphisms (SNPs) and breast tumor characteristics and assessed the potential interactions with smoking, alcohol consumption, adiposity and known breast cancer risk factors. variants were significantly associated with breast cancer risk regardless of estrogen and progesterone receptor status, metastasis, lymph node involvement and histologic and nuclear grade. The –breast cancer association was modified by smoking status, with increased risk for former and current smokers compared to never smokers; former/current smokers carrying two copies of the rs1219648 minor allele were at highest risk with a crude OR (95% confidence interval) of 2.11 (1.52–2.92) compared to never smokers with no rs1219648 variant alleles. Our study found no evidence for either modification of and breast cancer by alcohol intake or adiposity, even when analyses were stratified by menopausal status. Although these results require further replication, they may provide new insight into the possible new exposures that may interact with susceptibility alleles.
language: eng
source:
identifier: ISSN: 0020-7136 ; E-ISSN: 1097-0215 ; DOI: 10.1002/ijc.25686
fulltext: fulltext
issn:
  • 0020-7136
  • 00207136
  • 1097-0215
  • 10970215
url: Link


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titleFGFR2 intronic SNPs and breast cancer risk: Associations with tumor characteristics and interactions with exogenous exposures and other known breast cancer risk factors
creatorMarian, Catalin ; Ochs‐Balcom, Heather M. ; Nie, Jing ; Kallakury, Bhaskar V. ; Ambrosone, Christine B. ; Trevisan, Maurizio ; Edge, Stephen ; Shields, Peter G. ; Freudenheim, Jo L.
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subjectBreast Cancer ; Fgfr2 ; Gene–Environment Interactions
descriptionRecent genome‐wide association studies have revealed several new candidate genes for breast cancer, including fibroblast growth factor receptor 2 () gene. The associations were also replicated in several other independent studies. The next important step is to study whether these common variants interact with known breast cancer risk factors, exogenous exposures and tumor characteristics. In a population‐based case–control study of 1,170 breast cancer cases and 2,115 controls, we examined genetic associations of four intronic single‐nucleotide polymorphisms (SNPs) and breast tumor characteristics and assessed the potential interactions with smoking, alcohol consumption, adiposity and known breast cancer risk factors. variants were significantly associated with breast cancer risk regardless of estrogen and progesterone receptor status, metastasis, lymph node involvement and histologic and nuclear grade. The –breast cancer association was modified by smoking status, with increased risk for former and current smokers compared to never smokers; former/current smokers carrying two copies of the rs1219648 minor allele were at highest risk with a crude OR (95% confidence interval) of 2.11 (1.52–2.92) compared to never smokers with no rs1219648 variant alleles. Our study found no evidence for either modification of and breast cancer by alcohol intake or adiposity, even when analyses were stratified by menopausal status. Although these results require further replication, they may provide new insight into the possible new exposures that may interact with susceptibility alleles.
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descriptionRecent genome‐wide association studies have revealed several new candidate genes for breast cancer, including fibroblast growth factor receptor 2 () gene. The associations were also replicated in several other independent studies. The next important step is to study whether these common variants interact with known breast cancer risk factors, exogenous exposures and tumor characteristics. In a population‐based case–control study of 1,170 breast cancer cases and 2,115 controls, we examined genetic associations of four intronic single‐nucleotide polymorphisms (SNPs) and breast tumor characteristics and assessed the potential interactions with smoking, alcohol consumption, adiposity and known breast cancer risk factors. variants were significantly associated with breast cancer risk regardless of estrogen and progesterone receptor status, metastasis, lymph node involvement and histologic and nuclear grade. The –breast cancer association was modified by smoking status, with increased risk for former and current smokers compared to never smokers; former/current smokers carrying two copies of the rs1219648 minor allele were at highest risk with a crude OR (95% confidence interval) of 2.11 (1.52–2.92) compared to never smokers with no rs1219648 variant alleles. Our study found no evidence for either modification of and breast cancer by alcohol intake or adiposity, even when analyses were stratified by menopausal status. Although these results require further replication, they may provide new insight into the possible new exposures that may interact with susceptibility alleles.
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abstractRecent genome‐wide association studies have revealed several new candidate genes for breast cancer, including fibroblast growth factor receptor 2 () gene. The associations were also replicated in several other independent studies. The next important step is to study whether these common variants interact with known breast cancer risk factors, exogenous exposures and tumor characteristics. In a population‐based case–control study of 1,170 breast cancer cases and 2,115 controls, we examined genetic associations of four intronic single‐nucleotide polymorphisms (SNPs) and breast tumor characteristics and assessed the potential interactions with smoking, alcohol consumption, adiposity and known breast cancer risk factors. variants were significantly associated with breast cancer risk regardless of estrogen and progesterone receptor status, metastasis, lymph node involvement and histologic and nuclear grade. The –breast cancer association was modified by smoking status, with increased risk for former and current smokers compared to never smokers; former/current smokers carrying two copies of the rs1219648 minor allele were at highest risk with a crude OR (95% confidence interval) of 2.11 (1.52–2.92) compared to never smokers with no rs1219648 variant alleles. Our study found no evidence for either modification of and breast cancer by alcohol intake or adiposity, even when analyses were stratified by menopausal status. Although these results require further replication, they may provide new insight into the possible new exposures that may interact with susceptibility alleles.
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pubWiley Subscription Services, Inc., A Wiley Company
doi10.1002/ijc.25686
pages702-12
date2011-08-01