schliessen

Filtern

 

Bibliotheken

Therapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes

This study tested the therapeutic effects of vincristine sulfate and doxorubicin hydrochloride, each drug in 2 different formulations: (i) as a solution in saline, and (ii) encapsulated in sterically stabilized, long‐circulating liposomes composed of hydroge‐natedsoy‐phosphatidylcholine/cholesterol/... Full description

Journal Title: International Journal of Cancer 30 July 1993, Vol.54(6), pp.959-964
Main Author: Vaage, Jan
Other Authors: Donovan, Dorothy , Mayhew, Eric , Uster, Paul , Woodle, Martin
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0020-7136 ; E-ISSN: 1097-0215 ; DOI: 10.1002/ijc.2910540616
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: wj10.1002/ijc.2910540616
title: Therapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes
format: Article
creator:
  • Vaage, Jan
  • Donovan, Dorothy
  • Mayhew, Eric
  • Uster, Paul
  • Woodle, Martin
subjects:
  • Antineoplastic Combined Chemotherapy Protocols -- Administration & Dosage
  • Mammary Neoplasms, Experimental -- Drug Therapy
ispartof: International Journal of Cancer, 30 July 1993, Vol.54(6), pp.959-964
description: This study tested the therapeutic effects of vincristine sulfate and doxorubicin hydrochloride, each drug in 2 different formulations: (i) as a solution in saline, and (ii) encapsulated in sterically stabilized, long‐circulating liposomes composed of hydroge‐natedsoy‐phosphatidylcholine/cholesterol/polyethylene‐glycer‐ol‐distearoyl‐ phosphatidylethanolamine. The 4 drug preparations were used to treat s.c. implants of the mouse mammary carcinoma MC2. The drugs were given by i.v. injection over 15 to 18 days, starting 3 days after tumor implantation. The single‐drug therapeutic effects of vincristine (S‐VCR) and doxorubicin (Doxil) in liposomes were compared, and the 2 preparations were also tested in alternate and in simultaneous combinations. These new liposome formulations of vincristine and doxorubicin were significantly more effective than the free drugs in curing the mice. Alternate, semi‐weekly injection of both drugs gave the best therapeutic effect. Prolonged circulation time with increased accumulation in tumors are considered likely reasons for the improved therapeutic efficacy of both drugs when encapsulated in these liposomes.
language: eng
source:
identifier: ISSN: 0020-7136 ; E-ISSN: 1097-0215 ; DOI: 10.1002/ijc.2910540616
fulltext: fulltext
issn:
  • 0020-7136
  • 00207136
  • 1097-0215
  • 10970215
url: Link


@attributes
ID1560862569
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1002/ijc.2910540616
sourceidwj
recordidTN_wj10.1002/ijc.2910540616
sourcesystemOther
pqid75856580
display
typearticle
titleTherapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes
creatorVaage, Jan ; Donovan, Dorothy ; Mayhew, Eric ; Uster, Paul ; Woodle, Martin
ispartofInternational Journal of Cancer, 30 July 1993, Vol.54(6), pp.959-964
identifier
descriptionThis study tested the therapeutic effects of vincristine sulfate and doxorubicin hydrochloride, each drug in 2 different formulations: (i) as a solution in saline, and (ii) encapsulated in sterically stabilized, long‐circulating liposomes composed of hydroge‐natedsoy‐phosphatidylcholine/cholesterol/polyethylene‐glycer‐ol‐distearoyl‐ phosphatidylethanolamine. The 4 drug preparations were used to treat s.c. implants of the mouse mammary carcinoma MC2. The drugs were given by i.v. injection over 15 to 18 days, starting 3 days after tumor implantation. The single‐drug therapeutic effects of vincristine (S‐VCR) and doxorubicin (Doxil) in liposomes were compared, and the 2 preparations were also tested in alternate and in simultaneous combinations. These new liposome formulations of vincristine and doxorubicin were significantly more effective than the free drugs in curing the mice. Alternate, semi‐weekly injection of both drugs gave the best therapeutic effect. Prolonged circulation time with increased accumulation in tumors are considered likely reasons for the improved therapeutic efficacy of both drugs when encapsulated in these liposomes.
languageeng
source
subjectAntineoplastic Combined Chemotherapy Protocols -- Administration & Dosage ; Mammary Neoplasms, Experimental -- Drug Therapy;
version4
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Vaage, Jan
1Donovan, Dorothy
2Mayhew, Eric
3Uster, Paul
4Woodle, Martin
titleTherapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes
descriptionThis study tested the therapeutic effects of vincristine sulfate and doxorubicin hydrochloride, each drug in 2 different formulations: (i) as a solution in saline, and (ii) encapsulated in sterically stabilized, long‐circulating liposomes composed of hydroge‐natedsoy‐phosphatidylcholine/cholesterol/polyethylene‐glycer‐ol‐distearoyl‐ phosphatidylethanolamine. The 4 drug preparations were used to treat s.c. implants of the mouse mammary carcinoma MC2. The drugs were given by i.v. injection over 15 to 18 days, starting 3 days after tumor implantation. The single‐drug therapeutic effects of vincristine (S‐VCR) and doxorubicin (Doxil) in liposomes were compared, and the 2 preparations were also tested in alternate and in simultaneous combinations. These new liposome formulations of vincristine and doxorubicin were significantly more effective than the free drugs in curing the mice. Alternate, semi‐weekly injection of both drugs gave the best therapeutic effect. Prolonged circulation time with increased accumulation in tumors are considered likely reasons for the improved therapeutic efficacy of both drugs when encapsulated in these liposomes.
general
0English
1Wiley Subscription Services, Inc., A Wiley Company
210.1002/ijc.2910540616
3Wiley Online Library
sourceidwj
recordidwj10.1002/ijc.2910540616
issn
00020-7136
100207136
21097-0215
310970215
rsrctypearticle
creationdate1993
addtitle
0International Journal of Cancer
1Int. J. Cancer
searchscope
0wj
1wiley
scope
0wj
1wiley
lsr30VSR-Enriched:[pqid, pages, subject]
sort
titleTherapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes
authorVaage, Jan ; Donovan, Dorothy ; Mayhew, Eric ; Uster, Paul ; Woodle, Martin
creationdate19930730
facets
frbrgroupid9222198896784473859
frbrtype5
languageeng
creationdate1993
collectionWiley Online Library
prefilterarticles
rsrctypearticles
creatorcontrib
0Vaage, Jan
1Donovan, Dorothy
2Mayhew, Eric
3Uster, Paul
4Woodle, Martin
jtitleInternational Journal of Cancer
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Vaage
1Donovan
2Mayhew
3Uster
4Woodle
aufirst
0Jan
1Dorothy
2Eric
3Paul
4Martin
au
0Vaage, Jan
1Donovan, Dorothy
2Mayhew, Eric
3Uster, Paul
4Woodle, Martin
atitleTherapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes
jtitleInternational Journal of Cancer
risdate19930730
volume54
issue6
spage959
epage964
issn0020-7136
eissn1097-0215
genrearticle
ristypeJOUR
abstractThis study tested the therapeutic effects of vincristine sulfate and doxorubicin hydrochloride, each drug in 2 different formulations: (i) as a solution in saline, and (ii) encapsulated in sterically stabilized, long‐circulating liposomes composed of hydroge‐natedsoy‐phosphatidylcholine/cholesterol/polyethylene‐glycer‐ol‐distearoyl‐ phosphatidylethanolamine. The 4 drug preparations were used to treat s.c. implants of the mouse mammary carcinoma MC2. The drugs were given by i.v. injection over 15 to 18 days, starting 3 days after tumor implantation. The single‐drug therapeutic effects of vincristine (S‐VCR) and doxorubicin (Doxil) in liposomes were compared, and the 2 preparations were also tested in alternate and in simultaneous combinations. These new liposome formulations of vincristine and doxorubicin were significantly more effective than the free drugs in curing the mice. Alternate, semi‐weekly injection of both drugs gave the best therapeutic effect. Prolonged circulation time with increased accumulation in tumors are considered likely reasons for the improved therapeutic efficacy of both drugs when encapsulated in these liposomes.
copNew York
pubWiley Subscription Services, Inc., A Wiley Company
doi10.1002/ijc.2910540616
pages959-964
date1993-07-30