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Diabetes and cancer risk: A Mendelian randomization study

Earlier cohort studies using conventional regression models have consistently shown an increased cancer risk among individuals with type 2 diabetes. However, reverse causality and residual confounding due to common risk factors could exist, and it remains... What's new? While type 2 diabetes is impl... Full description

Journal Title: International Journal of Cancer 01 February 2020, Vol.146(3), pp.712-719
Main Author: Goto, Atsushi
Other Authors: Yamaji, Taiki , Sawada, Norie , Momozawa, Yukihide , Kamatani, Yoichiro , Kubo, Michiaki , Shimazu, Taichi , Inoue, Manami , Noda, Mitsuhiko , Tsugane, Shoichiro , Iwasaki, Motoki
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ID: ISSN: 0020-7136 ; E-ISSN: 1097-0215 ; DOI: 10.1002/ijc.32310
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recordid: wj10.1002/ijc.32310
title: Diabetes and cancer risk: A Mendelian randomization study
format: Article
creator:
  • Goto, Atsushi
  • Yamaji, Taiki
  • Sawada, Norie
  • Momozawa, Yukihide
  • Kamatani, Yoichiro
  • Kubo, Michiaki
  • Shimazu, Taichi
  • Inoue, Manami
  • Noda, Mitsuhiko
  • Tsugane, Shoichiro
  • Iwasaki, Motoki
subjects:
  • Diabetes
  • Mendelian Randomization
  • Genetics
  • Epidemiology
ispartof: International Journal of Cancer, 01 February 2020, Vol.146(3), pp.712-719
description: Earlier cohort studies using conventional regression models have consistently shown an increased cancer risk among individuals with type 2 diabetes. However, reverse causality and residual confounding due to common risk factors could exist, and it remains... What's new? While type 2 diabetes is implicated in cancer development, the two conditions share multiple risk factors, raising questions about the actual contribution of diabetes to cancer risk. Here, a Mendelian randomization (MR) analysis was used to clarify the...
language:
source:
identifier: ISSN: 0020-7136 ; E-ISSN: 1097-0215 ; DOI: 10.1002/ijc.32310
fulltext: fulltext
issn:
  • 0020-7136
  • 00207136
  • 1097-0215
  • 10970215
url: Link


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creatorGoto, Atsushi ; Yamaji, Taiki ; Sawada, Norie ; Momozawa, Yukihide ; Kamatani, Yoichiro ; Kubo, Michiaki ; Shimazu, Taichi ; Inoue, Manami ; Noda, Mitsuhiko ; Tsugane, Shoichiro ; Iwasaki, Motoki
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subjectDiabetes ; Mendelian Randomization ; Genetics ; Epidemiology
descriptionEarlier cohort studies using conventional regression models have consistently shown an increased cancer risk among individuals with type 2 diabetes. However, reverse causality and residual confounding due to common risk factors could exist, and it remains... What's new? While type 2 diabetes is implicated in cancer development, the two conditions share multiple risk factors, raising questions about the actual contribution of diabetes to cancer risk. Here, a Mendelian randomization (MR) analysis was used to clarify the...
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authorGoto, Atsushi ; Yamaji, Taiki ; Sawada, Norie ; Momozawa, Yukihide ; Kamatani, Yoichiro ; Kubo, Michiaki ; Shimazu, Taichi ; Inoue, Manami ; Noda, Mitsuhiko ; Tsugane, Shoichiro ; Iwasaki, Motoki
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abstractEarlier cohort studies using conventional regression models have consistently shown an increased cancer risk among individuals with type 2 diabetes. However, reverse causality and residual confounding due to common risk factors could exist, and it remains......
copHoboken, USA
pubJohn Wiley & Sons, Inc.
doi10.1002/ijc.32310
pages712-719
date2020-02-01