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Treatment of tumor in lymph nodes using near‐infrared laser light‐activated thermosensitive liposome‐encapsulated doxorubicin and gold nanorods

Tumor metastasis to lymph nodes is an important contributory factor for cancer‐related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to tri... Full description

Journal Title: Journal of Biophotonics December 2017, Vol.10(12), pp.1676-1682
Main Author: Matsuki, Daisuke
Other Authors: Adewale, Oladipo , Horie, Sachiko , Okajima, Junnosuke , Komiya, Atsuki , Oluwafemi, Oluwatobi , Maruyama, Shigenao , Mori, Shiro , Kodama, Tetsuya
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1864-063X ; E-ISSN: 1864-0648 ; DOI: 10.1002/jbio.201600241
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recordid: wj10.1002/jbio.201600241
title: Treatment of tumor in lymph nodes using near‐infrared laser light‐activated thermosensitive liposome‐encapsulated doxorubicin and gold nanorods
format: Article
creator:
  • Matsuki, Daisuke
  • Adewale, Oladipo
  • Horie, Sachiko
  • Okajima, Junnosuke
  • Komiya, Atsuki
  • Oluwafemi, Oluwatobi
  • Maruyama, Shigenao
  • Mori, Shiro
  • Kodama, Tetsuya
subjects:
  • Chemotherapy
  • Doxorubicin
  • Metastatic Lymph Nodes
  • Photothermal Treatment
  • Thermosensitive Agents
ispartof: Journal of Biophotonics, December 2017, Vol.10(12), pp.1676-1682
description: Tumor metastasis to lymph nodes is an important contributory factor for cancer‐related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading of doxorubicin (DOX) encapsulated in thermosensitive liposomes (TSLs) administered together with gold nanorods (GNRs). GNRs + DOX‐TSLs were injected into a mouse lymph node containing cancer cells (malignant fibrous histiocytoma‐like cells) and intranodal DOX release was activated using near‐infrared (NIR) laser irradiation. The temperature changes arising from the laser‐irradiated GNRs triggered the release of DOX from the TSLs. A greater degree of inhibition of tumor growth was found in the co‐therapy group compared to the other groups. The treatment effect was achieved by a combination of chemotherapy and NIR‐activated hyperthermia. bioluminescence imaging and histological analysis confirmed tumor necrosis in response to combined treatment. This work presents a theranostic approach with excellent treatment results that has the potential to be developed into an alternative to surgery for the treatment of breast cancer metastasis. Tumor metastasis to lymph nodes is an important contributory factor for cancer‐related deaths despite recent developments in cancer therapy. This study demonstrates that tumor in the lymph node of the mouse can be treated by the external near‐infrared laser light to trigger the unloading of doxorubicin encapsulated in thermosensitive liposomes administered together with gold nanorods. This work presents a theranostic approach that has the potential to treat metastatic lymph nodes.
language: eng
source:
identifier: ISSN: 1864-063X ; E-ISSN: 1864-0648 ; DOI: 10.1002/jbio.201600241
fulltext: fulltext
issn:
  • 1864-063X
  • 1864063X
  • 1864-0648
  • 18640648
url: Link


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titleTreatment of tumor in lymph nodes using near‐infrared laser light‐activated thermosensitive liposome‐encapsulated doxorubicin and gold nanorods
creatorMatsuki, Daisuke ; Adewale, Oladipo ; Horie, Sachiko ; Okajima, Junnosuke ; Komiya, Atsuki ; Oluwafemi, Oluwatobi ; Maruyama, Shigenao ; Mori, Shiro ; Kodama, Tetsuya
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subjectChemotherapy ; Doxorubicin ; Metastatic Lymph Nodes ; Photothermal Treatment ; Thermosensitive Agents
descriptionTumor metastasis to lymph nodes is an important contributory factor for cancer‐related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading of doxorubicin (DOX) encapsulated in thermosensitive liposomes (TSLs) administered together with gold nanorods (GNRs). GNRs + DOX‐TSLs were injected into a mouse lymph node containing cancer cells (malignant fibrous histiocytoma‐like cells) and intranodal DOX release was activated using near‐infrared (NIR) laser irradiation. The temperature changes arising from the laser‐irradiated GNRs triggered the release of DOX from the TSLs. A greater degree of inhibition of tumor growth was found in the co‐therapy group compared to the other groups. The treatment effect was achieved by a combination of chemotherapy and NIR‐activated hyperthermia. bioluminescence imaging and histological analysis confirmed tumor necrosis in response to combined treatment. This work presents a theranostic approach with excellent treatment results that has the potential to be developed into an alternative to surgery for the treatment of breast cancer metastasis. Tumor metastasis to lymph nodes is an important contributory factor for cancer‐related deaths despite recent developments in cancer therapy. This study demonstrates that tumor in the lymph node of the mouse can be treated by the external near‐infrared laser light to trigger the unloading of doxorubicin encapsulated in thermosensitive liposomes administered together with gold nanorods. This work presents a theranostic approach that has the potential to treat metastatic lymph nodes.
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titleTreatment of tumor in lymph nodes using near‐infrared laser light‐activated thermosensitive liposome‐encapsulated doxorubicin and gold nanorods
descriptionTumor metastasis to lymph nodes is an important contributory factor for cancer‐related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading of doxorubicin (DOX) encapsulated in thermosensitive liposomes (TSLs) administered together with gold nanorods (GNRs). GNRs + DOX‐TSLs were injected into a mouse lymph node containing cancer cells (malignant fibrous histiocytoma‐like cells) and intranodal DOX release was activated using near‐infrared (NIR) laser irradiation. The temperature changes arising from the laser‐irradiated GNRs triggered the release of DOX from the TSLs. A greater degree of inhibition of tumor growth was found in the co‐therapy group compared to the other groups. The treatment effect was achieved by a combination of chemotherapy and NIR‐activated hyperthermia. bioluminescence imaging and histological analysis confirmed tumor necrosis in response to combined treatment. This work presents a theranostic approach with excellent treatment results that has the potential to be developed into an alternative to surgery for the treatment of breast cancer metastasis. Tumor metastasis to lymph nodes is an important contributory factor for cancer‐related deaths despite recent developments in cancer therapy. This study demonstrates that tumor in the lymph node of the mouse can be treated by the external near‐infrared laser light to trigger the unloading of doxorubicin encapsulated in thermosensitive liposomes administered together with gold nanorods. This work presents a theranostic approach that has the potential to treat metastatic lymph nodes.
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titleTreatment of tumor in lymph nodes using near‐infrared laser light‐activated thermosensitive liposome‐encapsulated doxorubicin and gold nanorods
authorMatsuki, Daisuke ; Adewale, Oladipo ; Horie, Sachiko ; Okajima, Junnosuke ; Komiya, Atsuki ; Oluwafemi, Oluwatobi ; Maruyama, Shigenao ; Mori, Shiro ; Kodama, Tetsuya
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abstractTumor metastasis to lymph nodes is an important contributory factor for cancer‐related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading of doxorubicin (DOX) encapsulated in thermosensitive liposomes (TSLs) administered together with gold nanorods (GNRs). GNRs + DOX‐TSLs were injected into a mouse lymph node containing cancer cells (malignant fibrous histiocytoma‐like cells) and intranodal DOX release was activated using near‐infrared (NIR) laser irradiation. The temperature changes arising from the laser‐irradiated GNRs triggered the release of DOX from the TSLs. A greater degree of inhibition of tumor growth was found in the co‐therapy group compared to the other groups. The treatment effect was achieved by a combination of chemotherapy and NIR‐activated hyperthermia. bioluminescence imaging and histological analysis confirmed tumor necrosis in response to combined treatment. This work presents a theranostic approach with excellent treatment results that has the potential to be developed into an alternative to surgery for the treatment of breast cancer metastasis. Tumor metastasis to lymph nodes is an important contributory factor for cancer‐related deaths despite recent developments in cancer therapy. This study demonstrates that tumor in the lymph node of the mouse can be treated by the external near‐infrared laser light to trigger the unloading of doxorubicin encapsulated in thermosensitive liposomes administered together with gold nanorods. This work presents a theranostic approach that has the potential to treat metastatic lymph nodes.
doi10.1002/jbio.201600241
pages1676-1682
date2017-12