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Increased cerebral blood flow with increased amyloid burden in the preclinical phase of alzheimer's disease

Arterial spin labeling (ASL) is an emerging MRI technique for noninvasive measurement of cerebral blood flow (CBF) that has been used to show hemodynamic changes in the brains of people with Alzheimer's disease (AD). CBF changes have been measured using positron emission tomography (PET) across the... Full description

Journal Title: Journal of Magnetic Resonance Imaging February 2020, Vol.51(2), pp.505-513
Main Author: Fazlollahi, Amir
Other Authors: Calamante, Fernando , Liang, Xiaoyun , Bourgeat, Pierrick , Raniga, Parnesh , Dore, Vincent , Fripp, Jurgen , Ames, David , Masters, Colin L. , Rowe, Christopher C. , Connelly, Alan , Villemagne, Victor L. , Salvado, Olivier
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Cbf
ID: ISSN: 1053-1807 ; E-ISSN: 1522-2586 ; DOI: 10.1002/jmri.26810
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recordid: wj10.1002/jmri.26810
title: Increased cerebral blood flow with increased amyloid burden in the preclinical phase of alzheimer's disease
format: Article
creator:
  • Fazlollahi, Amir
  • Calamante, Fernando
  • Liang, Xiaoyun
  • Bourgeat, Pierrick
  • Raniga, Parnesh
  • Dore, Vincent
  • Fripp, Jurgen
  • Ames, David
  • Masters, Colin L.
  • Rowe, Christopher C.
  • Connelly, Alan
  • Villemagne, Victor L.
  • Salvado, Olivier
subjects:
  • Perfusion
  • Multiphase Pcasl
  • Preclinical Alzheimer'S Disease
  • Cbf
  • Amyloid
ispartof: Journal of Magnetic Resonance Imaging, February 2020, Vol.51(2), pp.505-513
description: Arterial spin labeling (ASL) is an emerging MRI technique for noninvasive measurement of cerebral blood flow (CBF) that has been used to show hemodynamic changes in the brains of people with Alzheimer's disease (AD). CBF changes have been measured using positron emission tomography (PET) across the AD spectrum, but ASL showed limited success in measuring CBF variations in the preclinical phase of AD, where amyloid β (Aβ) plaques accumulate in the decades prior to symptom onset. To investigate the relationship between CBF measured by multiphase-pseudocontinuous-ASL (MP-PCASL) and Aβ burden as measured by C-PiB PET imaging in a study of cognitively normal (CN) subjects age over 65. Cross-sectional. Forty-six CN subjects including 33 with low levels of Aβ burden and 13 with high levels of Aβ. 3T/3D MP-PCASL. The MP-PCASL method was chosen because it has a high signal-to-noise ratio. Furthermore, the data were analyzed using an efficient processing pipeline consisting of motion correction, ASL motion correction imprecision removal, temporal and spatial filtering, and partial volume effect correction. General Linear Model. In CN subjects positive for Aβ burden (n = 13), we observed a positive correlation between CBF and Aβ burden in the hippocampus, amygdala, caudate (P 
language:
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identifier: ISSN: 1053-1807 ; E-ISSN: 1522-2586 ; DOI: 10.1002/jmri.26810
fulltext: fulltext
issn:
  • 1053-1807
  • 10531807
  • 1522-2586
  • 15222586
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titleIncreased cerebral blood flow with increased amyloid burden in the preclinical phase of alzheimer's disease
creatorFazlollahi, Amir ; Calamante, Fernando ; Liang, Xiaoyun ; Bourgeat, Pierrick ; Raniga, Parnesh ; Dore, Vincent ; Fripp, Jurgen ; Ames, David ; Masters, Colin L. ; Rowe, Christopher C. ; Connelly, Alan ; Villemagne, Victor L. ; Salvado, Olivier
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descriptionArterial spin labeling (ASL) is an emerging MRI technique for noninvasive measurement of cerebral blood flow (CBF) that has been used to show hemodynamic changes in the brains of people with Alzheimer's disease (AD). CBF changes have been measured using positron emission tomography (PET) across the AD spectrum, but ASL showed limited success in measuring CBF variations in the preclinical phase of AD, where amyloid β (Aβ) plaques accumulate in the decades prior to symptom onset. To investigate the relationship between CBF measured by multiphase-pseudocontinuous-ASL (MP-PCASL) and Aβ burden as measured by C-PiB PET imaging in a study of cognitively normal (CN) subjects age over 65. Cross-sectional. Forty-six CN subjects including 33 with low levels of Aβ burden and 13 with high levels of Aβ. 3T/3D MP-PCASL. The MP-PCASL method was chosen because it has a high signal-to-noise ratio. Furthermore, the data were analyzed using an efficient processing pipeline consisting of motion correction, ASL motion correction imprecision removal, temporal and spatial filtering, and partial volume effect correction. General Linear Model. In CN subjects positive for Aβ burden (n = 13), we observed a positive correlation between CBF and Aβ burden in the hippocampus, amygdala, caudate (P < 0.01), frontal, temporal, and insula (P < 0.05). To the best of our knowledge, this is the first study using MP-PCASL in the study of AD, and the results suggest a potential compensatory hemodynamic mechanism that protects against pathology in the early stages of AD. 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2020;51:505-513.
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