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Effect of Repeated Injections of Adenosine Diphosphate‐Encapsulated Liposomes Coated with a Fibrinogen γ‐Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug‐Induced Thrombocytopenia Rat Model

Adenosine diphosphate ()‐encapsulated liposomes coated with a fibrinogen γ‐chain dodecapeptide [12 (dodecapeptide ())‐()‐liposome] is a synthetic platelet substitute, in which the surface is covered with polyethylene glycol (). It has been reported that repeated injections of ylated liposomes induce... Full description

Journal Title: Journal of Pharmaceutical Sciences September 2015, Vol.104(9), pp.3084-3091
Main Author: Taguchi, Kazuaki
Other Authors: Hashimoto, Mai , Ogaki, Shigeru , Watanabe, Hiroshi , Takeoka, Shinji , Ikeda, Yasuo , Handa, Makoto , Otagiri, Masaki , Maruyama, Toru
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ID: ISSN: 0022-3549 ; E-ISSN: 1520-6017 ; DOI: 10.1002/jps.24418
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recordid: wj10.1002/jps.24418
title: Effect of Repeated Injections of Adenosine Diphosphate‐Encapsulated Liposomes Coated with a Fibrinogen γ‐Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug‐Induced Thrombocytopenia Rat Model
format: Article
creator:
  • Taguchi, Kazuaki
  • Hashimoto, Mai
  • Ogaki, Shigeru
  • Watanabe, Hiroshi
  • Takeoka, Shinji
  • Ikeda, Yasuo
  • Handa, Makoto
  • Otagiri, Masaki
  • Maruyama, Toru
subjects:
  • Liposome
  • Adenosine‐Diphosphate
  • Dodecapeptide
  • Accelerated Blood Clearance Phenomenon
  • Thrombocytopenia
  • Platelet Substitute
  • Pegylation
  • Disposition
  • Clearance
  • Pharmacokinetics
ispartof: Journal of Pharmaceutical Sciences, September 2015, Vol.104(9), pp.3084-3091
description: Adenosine diphosphate ()‐encapsulated liposomes coated with a fibrinogen γ‐chain dodecapeptide [12 (dodecapeptide ())‐()‐liposome] is a synthetic platelet substitute, in which the surface is covered with polyethylene glycol (). It has been reported that repeated injections of ylated liposomes induce an accelerated blood clearance () phenomenon, which involves a loss in the long‐circulation half‐life of the material when administered repeatedly to the same animals. The objective of this study was to determine whether the phenomenon was induced by repeated injections of 12‐()‐liposome in healthy and anticancer drug‐induced thrombocytopenia model rats. The findings show that the phenomenon was induced by healthy rats that were repeatedly injected with 12‐()‐liposomes at the interval of 5 days at a dose of 10 mg lipids/kg. The phenomenon involves the production of anti‐12‐()‐liposome immunoglobulin (g) and complement activation. On the other hand, when thrombocytopenia model rats were repeatedly injected with 12‐()‐liposomes under the same conditions, no phenomenon, nor was any suppression of anti‐12‐()‐liposome g‐mediated complement activation observed. We thus conclude that the repeated injection of 12‐()‐liposome treatment in rat model with anticancer drug‐induced thrombocytopenia did not induce the phenomenon. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3084–3091, 2015
language:
source:
identifier: ISSN: 0022-3549 ; E-ISSN: 1520-6017 ; DOI: 10.1002/jps.24418
fulltext: fulltext
issn:
  • 0022-3549
  • 00223549
  • 1520-6017
  • 15206017
url: Link


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titleEffect of Repeated Injections of Adenosine Diphosphate‐Encapsulated Liposomes Coated with a Fibrinogen γ‐Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug‐Induced Thrombocytopenia Rat Model
creatorTaguchi, Kazuaki ; Hashimoto, Mai ; Ogaki, Shigeru ; Watanabe, Hiroshi ; Takeoka, Shinji ; Ikeda, Yasuo ; Handa, Makoto ; Otagiri, Masaki ; Maruyama, Toru
ispartofJournal of Pharmaceutical Sciences, September 2015, Vol.104(9), pp.3084-3091
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subjectLiposome ; Adenosine‐Diphosphate ; Dodecapeptide ; Accelerated Blood Clearance Phenomenon ; Thrombocytopenia ; Platelet Substitute ; Pegylation ; Disposition ; Clearance ; Pharmacokinetics
descriptionAdenosine diphosphate ()‐encapsulated liposomes coated with a fibrinogen γ‐chain dodecapeptide [12 (dodecapeptide ())‐()‐liposome] is a synthetic platelet substitute, in which the surface is covered with polyethylene glycol (). It has been reported that repeated injections of ylated liposomes induce an accelerated blood clearance () phenomenon, which involves a loss in the long‐circulation half‐life of the material when administered repeatedly to the same animals. The objective of this study was to determine whether the phenomenon was induced by repeated injections of 12‐()‐liposome in healthy and anticancer drug‐induced thrombocytopenia model rats. The findings show that the phenomenon was induced by healthy rats that were repeatedly injected with 12‐()‐liposomes at the interval of 5 days at a dose of 10 mg lipids/kg. The phenomenon involves the production of anti‐12‐()‐liposome immunoglobulin (g) and complement activation. On the other hand, when thrombocytopenia model rats were repeatedly injected with 12‐()‐liposomes under the same conditions, no phenomenon, nor was any suppression of anti‐12‐()‐liposome g‐mediated complement activation observed. We thus conclude that the repeated injection of 12‐()‐liposome treatment in rat model with anticancer drug‐induced thrombocytopenia did not induce the phenomenon. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3084–3091, 2015
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titleEffect of Repeated Injections of Adenosine Diphosphate‐Encapsulated Liposomes Coated with a Fibrinogen γ‐Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug‐Induced Thrombocytopenia Rat Model
descriptionAdenosine diphosphate ()‐encapsulated liposomes coated with a fibrinogen γ‐chain dodecapeptide [12 (dodecapeptide ())‐()‐liposome] is a synthetic platelet substitute, in which the surface is covered with polyethylene glycol (). It has been reported that repeated injections of ylated liposomes induce an accelerated blood clearance () phenomenon, which involves a loss in the long‐circulation half‐life of the material when administered repeatedly to the same animals. The objective of this study was to determine whether the phenomenon was induced by repeated injections of 12‐()‐liposome in healthy and anticancer drug‐induced thrombocytopenia model rats. The findings show that the phenomenon was induced by healthy rats that were repeatedly injected with 12‐()‐liposomes at the interval of 5 days at a dose of 10 mg lipids/kg. The phenomenon involves the production of anti‐12‐()‐liposome immunoglobulin (g) and complement activation. On the other hand, when thrombocytopenia model rats were repeatedly injected with 12‐()‐liposomes under the same conditions, no phenomenon, nor was any suppression of anti‐12‐()‐liposome g‐mediated complement activation observed. We thus conclude that the repeated injection of 12‐()‐liposome treatment in rat model with anticancer drug‐induced thrombocytopenia did not induce the phenomenon. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3084–3091, 2015
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titleEffect of Repeated Injections of Adenosine Diphosphate‐Encapsulated Liposomes Coated with a Fibrinogen γ‐Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug‐Induced Thrombocytopenia Rat Model
authorTaguchi, Kazuaki ; Hashimoto, Mai ; Ogaki, Shigeru ; Watanabe, Hiroshi ; Takeoka, Shinji ; Ikeda, Yasuo ; Handa, Makoto ; Otagiri, Masaki ; Maruyama, Toru
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abstractAdenosine diphosphate ()‐encapsulated liposomes coated with a fibrinogen γ‐chain dodecapeptide [12 (dodecapeptide ())‐()‐liposome] is a synthetic platelet substitute, in which the surface is covered with polyethylene glycol (). It has been reported that repeated injections of ylated liposomes induce an accelerated blood clearance () phenomenon, which involves a loss in the long‐circulation half‐life of the material when administered repeatedly to the same animals. The objective of this study was to determine whether the phenomenon was induced by repeated injections of 12‐()‐liposome in healthy and anticancer drug‐induced thrombocytopenia model rats. The findings show that the phenomenon was induced by healthy rats that were repeatedly injected with 12‐()‐liposomes at the interval of 5 days at a dose of 10 mg lipids/kg. The phenomenon involves the production of anti‐12‐()‐liposome immunoglobulin (g) and complement activation. On the other hand, when thrombocytopenia model rats were repeatedly injected with 12‐()‐liposomes under the same conditions, no phenomenon, nor was any suppression of anti‐12‐()‐liposome g‐mediated complement activation observed. We thus conclude that the repeated injection of 12‐()‐liposome treatment in rat model with anticancer drug‐induced thrombocytopenia did not induce the phenomenon. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3084–3091, 2015
doi10.1002/jps.24418
pages3084-3091
date2015-09