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Temperature and pH Controlled Self‐Assembly of a Protein–Polymer Biohybrid

A novel pH and temperature dual‐responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH‐responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biom... Full description

Journal Title: Macromolecular Chemistry and Physics April 2018, Vol.219(7), pp.n/a-n/a
Main Author: Jiang, Lingdong
Other Authors: Bonde, Johan Svensson , Ye, Lei
Format: Electronic Article Electronic Article
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ID: ISSN: 1022-1352 ; E-ISSN: 1521-3935 ; DOI: 10.1002/macp.201700597
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recordid: wj10.1002/macp.201700597
title: Temperature and pH Controlled Self‐Assembly of a Protein–Polymer Biohybrid
format: Article
creator:
  • Jiang, Lingdong
  • Bonde, Johan Svensson
  • Ye, Lei
subjects:
  • Amelogenin
  • Atom Transfer Radical Polymerization
  • Bioconjugate
  • Dual‐Responsive
  • Self‐Assembly
ispartof: Macromolecular Chemistry and Physics, April 2018, Vol.219(7), pp.n/a-n/a
description: A novel pH and temperature dual‐responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH‐responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli‐responsive property. In both basic and acidic solutions the protein–polymer bioconjugate is able to self‐assemble into uniform and stable nanoparticles when heated to above the lower critical solution temperature of the polymer. The amelogenin‐based stimuli‐responsive bioconjugate may be of great use in the fields of bioseparation and drug/gene delivery, and the synthetic approach reported here should provide a convenient means to preparing amelogenin‐based functional biohybrid materials. is prepared by grafting poly(‐isopropylacrylamide) chains from the pH‐responsive protein amelogenin via atom transfer radical polymerization technique. This hybrid biopolymer is able to self‐assemble into highly uniform nanoparticles by adjusting environmental conditions and is promising for applications in bioseparation and drug delivery fields.
language:
source:
identifier: ISSN: 1022-1352 ; E-ISSN: 1521-3935 ; DOI: 10.1002/macp.201700597
fulltext: fulltext
issn:
  • 1022-1352
  • 10221352
  • 1521-3935
  • 15213935
url: Link


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titleTemperature and pH Controlled Self‐Assembly of a Protein–Polymer Biohybrid
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subjectAmelogenin ; Atom Transfer Radical Polymerization ; Bioconjugate ; Dual‐Responsive ; Self‐Assembly
descriptionA novel pH and temperature dual‐responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH‐responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli‐responsive property. In both basic and acidic solutions the protein–polymer bioconjugate is able to self‐assemble into uniform and stable nanoparticles when heated to above the lower critical solution temperature of the polymer. The amelogenin‐based stimuli‐responsive bioconjugate may be of great use in the fields of bioseparation and drug/gene delivery, and the synthetic approach reported here should provide a convenient means to preparing amelogenin‐based functional biohybrid materials. is prepared by grafting poly(‐isopropylacrylamide) chains from the pH‐responsive protein amelogenin via atom transfer radical polymerization technique. This hybrid biopolymer is able to self‐assemble into highly uniform nanoparticles by adjusting environmental conditions and is promising for applications in bioseparation and drug delivery fields.
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titleTemperature and pH Controlled Self‐Assembly of a Protein–Polymer Biohybrid
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abstractA novel pH and temperature dual‐responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH‐responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli‐responsive property. In both basic and acidic solutions the protein–polymer bioconjugate is able to self‐assemble into uniform and stable nanoparticles when heated to above the lower critical solution temperature of the polymer. The amelogenin‐based stimuli‐responsive bioconjugate may be of great use in the fields of bioseparation and drug/gene delivery, and the synthetic approach reported here should provide a convenient means to preparing amelogenin‐based functional biohybrid materials. is prepared by grafting poly(‐isopropylacrylamide) chains from the pH‐responsive protein amelogenin via atom transfer radical polymerization technique. This hybrid biopolymer is able to self‐assemble into highly uniform nanoparticles by adjusting environmental conditions and is promising for applications in bioseparation and drug delivery fields.
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