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One‐Pot Glovebox‐Free Synthesis, Characterization, and Self‐Assembly of Novel Amphiphilic Poly(Sarcosine‐ b ‐Caprolactone) Diblock Copolymers

Novel amphiphilic polypeptoid‐polyester diblock copolymers based on poly(sarcosine) (PSar) and poly(‐caprolactone) (PCL) are synthesized by a one‐pot glovebox‐free approach. In this method, sarcosine ‐carboxy anhydride (Sar‐NCA) is firstly polymerized in the presence of benzylamine under N flow, the... Full description

Journal Title: Macromolecular Rapid Communications November 2014, Vol.35(22), pp.1954-1959
Main Author: Cui, Saide
Other Authors: Wang, Xin , Li, Zhenjiang , Zhang, Qiguo , Wu, Wenzhuo , Liu, Jingjing , Wu, Hao , Chen, Cheng , Guo, Kai
Format: Electronic Article Electronic Article
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ID: ISSN: 1022-1336 ; E-ISSN: 1521-3927 ; DOI: 10.1002/marc.201400348
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recordid: wj10.1002/marc.201400348
title: One‐Pot Glovebox‐Free Synthesis, Characterization, and Self‐Assembly of Novel Amphiphilic Poly(Sarcosine‐ b ‐Caprolactone) Diblock Copolymers
format: Article
creator:
  • Cui, Saide
  • Wang, Xin
  • Li, Zhenjiang
  • Zhang, Qiguo
  • Wu, Wenzhuo
  • Liu, Jingjing
  • Wu, Hao
  • Chen, Cheng
  • Guo, Kai
subjects:
  • Block Copolymers
  • Living Polymerization
  • Polyesters
  • Polypeptoids
  • Ring‐Opening Polymerization
ispartof: Macromolecular Rapid Communications, November 2014, Vol.35(22), pp.1954-1959
description: Novel amphiphilic polypeptoid‐polyester diblock copolymers based on poly(sarcosine) (PSar) and poly(‐caprolactone) (PCL) are synthesized by a one‐pot glovebox‐free approach. In this method, sarcosine ‐carboxy anhydride (Sar‐NCA) is firstly polymerized in the presence of benzylamine under N flow, then the resulting poly(sarcosine) is used in situ as the macro­initiator for the ring‐opening polymerization (ROP) of ‐caprolactone using tin(II) octanoate as a catalyst. The degree of poly­merization of each block is controlled by various feed ratios of monomer/initiator. The diblock copolymers with controlled molecular weight and narrow molecular weight distributions ( < 1.2) are characterized by H NMR, C NMR, and size‐exclusion chromatography. The self‐assembly behavior of PSar‐‐PCL in water is investigated by dynamic light scattering (DLS) and transmission electron microscopy. DLS results reveal that the diblock copolymers associate into nanoparticles with average hydrodynamic diameters () around 100 nm in water, which may be used as drug delivery carriers. composed of poly(sarcosine) (PSar) as the hydrophilic block and poly(ε‐caprolactone) (PCL) as the hydrophobic block are synthesized by a one‐pot glovebox‐free approach. PSar is firstly used as macroinitiator for the ring‐opening polymerization (ROP) of ‐caprolactone monomer to obtain PSar‐‐PCL copolymers with controlled molecular weight and narrow molecular weight distributions. PSar–PCL can self‐assemble into nanoparticles in aqueous solution.
language:
source:
identifier: ISSN: 1022-1336 ; E-ISSN: 1521-3927 ; DOI: 10.1002/marc.201400348
fulltext: fulltext
issn:
  • 1022-1336
  • 10221336
  • 1521-3927
  • 15213927
url: Link


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titleOne‐Pot Glovebox‐Free Synthesis, Characterization, and Self‐Assembly of Novel Amphiphilic Poly(Sarcosine‐ b ‐Caprolactone) Diblock Copolymers
creatorCui, Saide ; Wang, Xin ; Li, Zhenjiang ; Zhang, Qiguo ; Wu, Wenzhuo ; Liu, Jingjing ; Wu, Hao ; Chen, Cheng ; Guo, Kai
ispartofMacromolecular Rapid Communications, November 2014, Vol.35(22), pp.1954-1959
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descriptionNovel amphiphilic polypeptoid‐polyester diblock copolymers based on poly(sarcosine) (PSar) and poly(‐caprolactone) (PCL) are synthesized by a one‐pot glovebox‐free approach. In this method, sarcosine ‐carboxy anhydride (Sar‐NCA) is firstly polymerized in the presence of benzylamine under N flow, then the resulting poly(sarcosine) is used in situ as the macro­initiator for the ring‐opening polymerization (ROP) of ‐caprolactone using tin(II) octanoate as a catalyst. The degree of poly­merization of each block is controlled by various feed ratios of monomer/initiator. The diblock copolymers with controlled molecular weight and narrow molecular weight distributions ( < 1.2) are characterized by H NMR, C NMR, and size‐exclusion chromatography. The self‐assembly behavior of PSar‐‐PCL in water is investigated by dynamic light scattering (DLS) and transmission electron microscopy. DLS results reveal that the diblock copolymers associate into nanoparticles with average hydrodynamic diameters () around 100 nm in water, which may be used as drug delivery carriers. composed of poly(sarcosine) (PSar) as the hydrophilic block and poly(ε‐caprolactone) (PCL) as the hydrophobic block are synthesized by a one‐pot glovebox‐free approach. PSar is firstly used as macroinitiator for the ring‐opening polymerization (ROP) of ‐caprolactone monomer to obtain PSar‐‐PCL copolymers with controlled molecular weight and narrow molecular weight distributions. PSar–PCL can self‐assemble into nanoparticles in aqueous solution.
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titleOne‐Pot Glovebox‐Free Synthesis, Characterization, and Self‐Assembly of Novel Amphiphilic Poly(Sarcosine‐ b ‐Caprolactone) Diblock Copolymers
descriptionNovel amphiphilic polypeptoid‐polyester diblock copolymers based on poly(sarcosine) (PSar) and poly(‐caprolactone) (PCL) are synthesized by a one‐pot glovebox‐free approach. In this method, sarcosine ‐carboxy anhydride (Sar‐NCA) is firstly polymerized in the presence of benzylamine under N flow, then the resulting poly(sarcosine) is used in situ as the macro­initiator for the ring‐opening polymerization (ROP) of ‐caprolactone using tin(II) octanoate as a catalyst. The degree of poly­merization of each block is controlled by various feed ratios of monomer/initiator. The diblock copolymers with controlled molecular weight and narrow molecular weight distributions ( < 1.2) are characterized by H NMR, C NMR, and size‐exclusion chromatography. The self‐assembly behavior of PSar‐‐PCL in water is investigated by dynamic light scattering (DLS) and transmission electron microscopy. DLS results reveal that the diblock copolymers associate into nanoparticles with average hydrodynamic diameters () around 100 nm in water, which may be used as drug delivery carriers. composed of poly(sarcosine) (PSar) as the hydrophilic block and poly(ε‐caprolactone) (PCL) as the hydrophobic block are synthesized by a one‐pot glovebox‐free approach. PSar is firstly used as macroinitiator for the ring‐opening polymerization (ROP) of ‐caprolactone monomer to obtain PSar‐‐PCL copolymers with controlled molecular weight and narrow molecular weight distributions. PSar–PCL can self‐assemble into nanoparticles in aqueous solution.
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titleOne‐Pot Glovebox‐Free Synthesis, Characterization, and Self‐Assembly of Novel Amphiphilic Poly(Sarcosine‐ b ‐Caprolactone) Diblock Copolymers
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abstractNovel amphiphilic polypeptoid‐polyester diblock copolymers based on poly(sarcosine) (PSar) and poly(‐caprolactone) (PCL) are synthesized by a one‐pot glovebox‐free approach. In this method, sarcosine ‐carboxy anhydride (Sar‐NCA) is firstly polymerized in the presence of benzylamine under N flow, then the resulting poly(sarcosine) is used in situ as the macro­initiator for the ring‐opening polymerization (ROP) of ‐caprolactone using tin(II) octanoate as a catalyst. The degree of poly­merization of each block is controlled by various feed ratios of monomer/initiator. The diblock copolymers with controlled molecular weight and narrow molecular weight distributions ( < 1.2) are characterized by H NMR, C NMR, and size‐exclusion chromatography. The self‐assembly behavior of PSar‐‐PCL in water is investigated by dynamic light scattering (DLS) and transmission electron microscopy. DLS results reveal that the diblock copolymers associate into nanoparticles with average hydrodynamic diameters () around 100 nm in water, which may be used as drug delivery carriers. composed of poly(sarcosine) (PSar) as the hydrophilic block and poly(ε‐caprolactone) (PCL) as the hydrophobic block are synthesized by a one‐pot glovebox‐free approach. PSar is firstly used as macroinitiator for the ring‐opening polymerization (ROP) of ‐caprolactone monomer to obtain PSar‐‐PCL copolymers with controlled molecular weight and narrow molecular weight distributions. PSar–PCL can self‐assemble into nanoparticles in aqueous solution.
doi10.1002/marc.201400348
pages1954-1959
date2014-11