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Metabolic effects of Hedyotis diffusa on rats bearing Walker 256 tumor revealed by NMR‐based metabolomics

, a traditional Chinese herbal medicine, is widely used for oncotherapy and shows a positive effect in the clinical treatment. But its mechanism of anticancer activities is complicated and unclear. This study was undertaken to assess the therapeutic effects and reveal detailed mechanisms of .  for o... Full description

Journal Title: Magnetic Resonance in Chemistry January 2018, Vol.56(1), pp.5-17
Main Author: Wang, Zhiyong
Other Authors: Gao, Kuo , Xu, Can , Gao, Jian , Yan, Yujing , Wang, Yingfeng , Li, Zhongfeng , Chen, Jianxin
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ID: ISSN: 0749-1581 ; E-ISSN: 1097-458X ; DOI: 10.1002/mrc.4658
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title: Metabolic effects of Hedyotis diffusa on rats bearing Walker 256 tumor revealed by NMR‐based metabolomics
format: Article
creator:
  • Wang, Zhiyong
  • Gao, Kuo
  • Xu, Can
  • Gao, Jian
  • Yan, Yujing
  • Wang, Yingfeng
  • Li, Zhongfeng
  • Chen, Jianxin
subjects:
  • 1 H Nmr
  • Biomarkers
  • Hedyotis Diffusa
  • Metabolomics
  • W Alker 256 Tumor
ispartof: Magnetic Resonance in Chemistry, January 2018, Vol.56(1), pp.5-17
description: , a traditional Chinese herbal medicine, is widely used for oncotherapy and shows a positive effect in the clinical treatment. But its mechanism of anticancer activities is complicated and unclear. This study was undertaken to assess the therapeutic effects and reveal detailed mechanisms of .  for oncotherapy. A Walker 256 tumor‐bearing rat model was established, and metabolomic profiles of plasma and urine were obtained from H NMR technique. Multivariate statistical analysis methods were used to characterize the discriminating metabolites between control (C), Walker 256 tumor‐bearing rats model (M), and .  treatment (H) groups. Finally, 13 and 10 metabolomic biomarkers in urine and plasma samples were further identified as characteristic metabolites in M group, whereas H group showed a partial metabolic balance recovered, such as ornithine, ‐acetyl‐‐aspartate, ‐aspartate, and creatinine in urine samples, and acetate, lactate, choline, ‐glutamine, and 3‐hydroxybutyrate in plasma samples. On the basis of the methods above, we hypothesized .  treatment reduced the injury caused by Walker 256 tumor and maintained a metabolic balance. Our study demonstrated that this method provided new insights into metabolic alterations in tumor‐bearing biosystems and researching on the effects of .  on the endogenous metabolism in tumor‐bearing rats. A walker 256 tumor‐bearing rat model was established, and metabolomic profiles of plasma and urine obtained from H NMR technique combined with time‐course metabolites analysis were carried out to assess the therapeutic effects and reveal detailed mechanisms of for oncotherapy. We hypothesized treatment reduced the injury caused by Walker 256 tumor and maintained a metabolic balance, and such effect might result from amino acid metabolism, energy metabolism, and lipid metabolism.
language:
source:
identifier: ISSN: 0749-1581 ; E-ISSN: 1097-458X ; DOI: 10.1002/mrc.4658
fulltext: fulltext
issn:
  • 0749-1581
  • 07491581
  • 1097-458X
  • 1097458X
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titleMetabolic effects of Hedyotis diffusa on rats bearing Walker 256 tumor revealed by NMR‐based metabolomics
creatorWang, Zhiyong ; Gao, Kuo ; Xu, Can ; Gao, Jian ; Yan, Yujing ; Wang, Yingfeng ; Li, Zhongfeng ; Chen, Jianxin
ispartofMagnetic Resonance in Chemistry, January 2018, Vol.56(1), pp.5-17
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subject1 H Nmr ; Biomarkers ; Hedyotis Diffusa ; Metabolomics ; W Alker 256 Tumor
description, a traditional Chinese herbal medicine, is widely used for oncotherapy and shows a positive effect in the clinical treatment. But its mechanism of anticancer activities is complicated and unclear. This study was undertaken to assess the therapeutic effects and reveal detailed mechanisms of .  for oncotherapy. A Walker 256 tumor‐bearing rat model was established, and metabolomic profiles of plasma and urine were obtained from H NMR technique. Multivariate statistical analysis methods were used to characterize the discriminating metabolites between control (C), Walker 256 tumor‐bearing rats model (M), and .  treatment (H) groups. Finally, 13 and 10 metabolomic biomarkers in urine and plasma samples were further identified as characteristic metabolites in M group, whereas H group showed a partial metabolic balance recovered, such as ornithine, ‐acetyl‐‐aspartate, ‐aspartate, and creatinine in urine samples, and acetate, lactate, choline, ‐glutamine, and 3‐hydroxybutyrate in plasma samples. On the basis of the methods above, we hypothesized .  treatment reduced the injury caused by Walker 256 tumor and maintained a metabolic balance. Our study demonstrated that this method provided new insights into metabolic alterations in tumor‐bearing biosystems and researching on the effects of .  on the endogenous metabolism in tumor‐bearing rats. A walker 256 tumor‐bearing rat model was established, and metabolomic profiles of plasma and urine obtained from H NMR technique combined with time‐course metabolites analysis were carried out to assess the therapeutic effects and reveal detailed mechanisms of for oncotherapy. We hypothesized treatment reduced the injury caused by Walker 256 tumor and maintained a metabolic balance, and such effect might result from amino acid metabolism, energy metabolism, and lipid metabolism.
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titleMetabolic effects of Hedyotis diffusa on rats bearing Walker 256 tumor revealed by NMR‐based metabolomics
description, a traditional Chinese herbal medicine, is widely used for oncotherapy and shows a positive effect in the clinical treatment. But its mechanism of anticancer activities is complicated and unclear. This study was undertaken to assess the therapeutic effects and reveal detailed mechanisms of .  for oncotherapy. A Walker 256 tumor‐bearing rat model was established, and metabolomic profiles of plasma and urine were obtained from H NMR technique. Multivariate statistical analysis methods were used to characterize the discriminating metabolites between control (C), Walker 256 tumor‐bearing rats model (M), and .  treatment (H) groups. Finally, 13 and 10 metabolomic biomarkers in urine and plasma samples were further identified as characteristic metabolites in M group, whereas H group showed a partial metabolic balance recovered, such as ornithine, ‐acetyl‐‐aspartate, ‐aspartate, and creatinine in urine samples, and acetate, lactate, choline, ‐glutamine, and 3‐hydroxybutyrate in plasma samples. On the basis of the methods above, we hypothesized .  treatment reduced the injury caused by Walker 256 tumor and maintained a metabolic balance. Our study demonstrated that this method provided new insights into metabolic alterations in tumor‐bearing biosystems and researching on the effects of .  on the endogenous metabolism in tumor‐bearing rats. A walker 256 tumor‐bearing rat model was established, and metabolomic profiles of plasma and urine obtained from H NMR technique combined with time‐course metabolites analysis were carried out to assess the therapeutic effects and reveal detailed mechanisms of for oncotherapy. We hypothesized treatment reduced the injury caused by Walker 256 tumor and maintained a metabolic balance, and such effect might result from amino acid metabolism, energy metabolism, and lipid metabolism.
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titleMetabolic effects of Hedyotis diffusa on rats bearing Walker 256 tumor revealed by NMR‐based metabolomics
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abstract, a traditional Chinese herbal medicine, is widely used for oncotherapy and shows a positive effect in the clinical treatment. But its mechanism of anticancer activities is complicated and unclear. This study was undertaken to assess the therapeutic effects and reveal detailed mechanisms of .  for oncotherapy. A Walker 256 tumor‐bearing rat model was established, and metabolomic profiles of plasma and urine were obtained from H NMR technique. Multivariate statistical analysis methods were used to characterize the discriminating metabolites between control (C), Walker 256 tumor‐bearing rats model (M), and .  treatment (H) groups. Finally, 13 and 10 metabolomic biomarkers in urine and plasma samples were further identified as characteristic metabolites in M group, whereas H group showed a partial metabolic balance recovered, such as ornithine, ‐acetyl‐‐aspartate, ‐aspartate, and creatinine in urine samples, and acetate, lactate, choline, ‐glutamine, and 3‐hydroxybutyrate in plasma samples. On the basis of the methods above, we hypothesized .  treatment reduced the injury caused by Walker 256 tumor and maintained a metabolic balance. Our study demonstrated that this method provided new insights into metabolic alterations in tumor‐bearing biosystems and researching on the effects of .  on the endogenous metabolism in tumor‐bearing rats. A walker 256 tumor‐bearing rat model was established, and metabolomic profiles of plasma and urine obtained from H NMR technique combined with time‐course metabolites analysis were carried out to assess the therapeutic effects and reveal detailed mechanisms of for oncotherapy. We hypothesized treatment reduced the injury caused by Walker 256 tumor and maintained a metabolic balance, and such effect might result from amino acid metabolism, energy metabolism, and lipid metabolism.
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date2018-01