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Utility of gradient recalled echo magnetic resonance imaging for the study of myelination in cuprizone mice treated with fingolimod

The availability of high‐field‐strength magnetic resonance imaging (MRI) systems has brought about the development of techniques that aim to map myelination via the exploitation of various contrast mechanisms. Myelin mapping techniques have the potential to provide tools for the diagnosis and treatm... Full description

Journal Title: NMR in Biomedicine March 2018, Vol.31(3), pp.n/a-n/a
Main Author: Ziser, Laura
Other Authors: Meyer‐Schell, Naja , Kurniawan, Nyoman D. , Sullivan, Robert , Reutens, David , Chen, Min , Vegh, Viktor
Format: Electronic Article Electronic Article
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ID: ISSN: 0952-3480 ; E-ISSN: 1099-1492 ; DOI: 10.1002/nbm.3877
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title: Utility of gradient recalled echo magnetic resonance imaging for the study of myelination in cuprizone mice treated with fingolimod
format: Article
creator:
  • Ziser, Laura
  • Meyer‐Schell, Naja
  • Kurniawan, Nyoman D.
  • Sullivan, Robert
  • Reutens, David
  • Chen, Min
  • Vegh, Viktor
subjects:
  • Magnetic Resonance Imaging
  • Magnetic Susceptibility
  • Myelination
  • Ultra‐High Field
ispartof: NMR in Biomedicine, March 2018, Vol.31(3), pp.n/a-n/a
description: The availability of high‐field‐strength magnetic resonance imaging (MRI) systems has brought about the development of techniques that aim to map myelination via the exploitation of various contrast mechanisms. Myelin mapping techniques have the potential to provide tools for the diagnosis and treatment of diseases, such as multiple sclerosis. In this study, we evaluated the sensitivity of *, frequency shift and susceptibility measures to myelin levels in a cuprizone mouse model of demyelination. The model was supplemented with two different dosages of fingolimod, a drug known to positively affect demyelination. A decrease in grey–white matter contrast with the cuprizone diet was observed for *, frequency shift and susceptibility measures, together with myelin basic protein antibody findings. These results indicate that *, frequency shift and susceptibility measures have the potential to act as biomarkers for myelination. Susceptibility was found to be the most sensitive measure to changes in grey–white matter contrast. In addition, fingolimod treatment was found to reduce the level of demyelination, with a larger dosage exhibiting a greater reduction in demyelination for the MRI results. Overall, susceptibility mapping appears to be a more promising tool than * or frequency shift mapping for the early diagnosis and treatment of diseases in which myelination is implicated. Grey–white matter contrasts in *, frequency shift and susceptibility were measured in a cuprizone mouse model of demyelination supplemented with two different doses of fingolimod. All three measures displayed a reduction in contrast between the control and untreated cuprizone cohorts, indicating that *, frequency shift and susceptibility, which showed the greatest sensitivity to myelin levels, could act as suitable biomarkers for demyelination. Both doses of fingolimod were also shown to positively affect myelination levels.
language:
source:
identifier: ISSN: 0952-3480 ; E-ISSN: 1099-1492 ; DOI: 10.1002/nbm.3877
fulltext: fulltext
issn:
  • 0952-3480
  • 09523480
  • 1099-1492
  • 10991492
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titleUtility of gradient recalled echo magnetic resonance imaging for the study of myelination in cuprizone mice treated with fingolimod
creatorZiser, Laura ; Meyer‐Schell, Naja ; Kurniawan, Nyoman D. ; Sullivan, Robert ; Reutens, David ; Chen, Min ; Vegh, Viktor
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subjectMagnetic Resonance Imaging ; Magnetic Susceptibility ; Myelination ; Ultra‐High Field
descriptionThe availability of high‐field‐strength magnetic resonance imaging (MRI) systems has brought about the development of techniques that aim to map myelination via the exploitation of various contrast mechanisms. Myelin mapping techniques have the potential to provide tools for the diagnosis and treatment of diseases, such as multiple sclerosis. In this study, we evaluated the sensitivity of *, frequency shift and susceptibility measures to myelin levels in a cuprizone mouse model of demyelination. The model was supplemented with two different dosages of fingolimod, a drug known to positively affect demyelination. A decrease in grey–white matter contrast with the cuprizone diet was observed for *, frequency shift and susceptibility measures, together with myelin basic protein antibody findings. These results indicate that *, frequency shift and susceptibility measures have the potential to act as biomarkers for myelination. Susceptibility was found to be the most sensitive measure to changes in grey–white matter contrast. In addition, fingolimod treatment was found to reduce the level of demyelination, with a larger dosage exhibiting a greater reduction in demyelination for the MRI results. Overall, susceptibility mapping appears to be a more promising tool than * or frequency shift mapping for the early diagnosis and treatment of diseases in which myelination is implicated. Grey–white matter contrasts in *, frequency shift and susceptibility were measured in a cuprizone mouse model of demyelination supplemented with two different doses of fingolimod. All three measures displayed a reduction in contrast between the control and untreated cuprizone cohorts, indicating that *, frequency shift and susceptibility, which showed the greatest sensitivity to myelin levels, could act as suitable biomarkers for demyelination. Both doses of fingolimod were also shown to positively affect myelination levels.
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abstractThe availability of high‐field‐strength magnetic resonance imaging (MRI) systems has brought about the development of techniques that aim to map myelination via the exploitation of various contrast mechanisms. Myelin mapping techniques have the potential to provide tools for the diagnosis and treatment of diseases, such as multiple sclerosis. In this study, we evaluated the sensitivity of *, frequency shift and susceptibility measures to myelin levels in a cuprizone mouse model of demyelination. The model was supplemented with two different dosages of fingolimod, a drug known to positively affect demyelination. A decrease in grey–white matter contrast with the cuprizone diet was observed for *, frequency shift and susceptibility measures, together with myelin basic protein antibody findings. These results indicate that *, frequency shift and susceptibility measures have the potential to act as biomarkers for myelination. Susceptibility was found to be the most sensitive measure to changes in grey–white matter contrast. In addition, fingolimod treatment was found to reduce the level of demyelination, with a larger dosage exhibiting a greater reduction in demyelination for the MRI results. Overall, susceptibility mapping appears to be a more promising tool than * or frequency shift mapping for the early diagnosis and treatment of diseases in which myelination is implicated. Grey–white matter contrasts in *, frequency shift and susceptibility were measured in a cuprizone mouse model of demyelination supplemented with two different doses of fingolimod. All three measures displayed a reduction in contrast between the control and untreated cuprizone cohorts, indicating that *, frequency shift and susceptibility, which showed the greatest sensitivity to myelin levels, could act as suitable biomarkers for demyelination. Both doses of fingolimod were also shown to positively affect myelination levels.
doi10.1002/nbm.3877
orcidid0000-0002-4310-1421
date2018-03