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Impact on weight and physical function of intensive medical weight loss in older adults with stage II and III obesity

OBJECTIVE: A 6-month pilot trial compared two strategies for weight loss in older adults with body mass indexes (BMIs) ≥35 kg/m(2) to assess weight loss response, safety, and impact on physical function.METHODS: Twenty-eight volunteers were randomized to a balanced deficit diet (BDD) (500 kcal/day b... Full description

Journal Title: Obesity September 2016, Vol.24(9), pp.1861-1866
Main Author: Ard, Jamy D.
Other Authors: Cook, Miranda , Rushing, Julia , Frain, Annette , Beavers, Kristen , Miller, Gary , Miller, Michael E. , Nicklas, Barb
Format: Electronic Article Electronic Article
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ID: ISSN: 1930-7381 ; E-ISSN: 1930-739X ; DOI: 10.1002/oby.21569
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recordid: wj10.1002/oby.21569
title: Impact on weight and physical function of intensive medical weight loss in older adults with stage II and III obesity
format: Article
creator:
  • Ard, Jamy D.
  • Cook, Miranda
  • Rushing, Julia
  • Frain, Annette
  • Beavers, Kristen
  • Miller, Gary
  • Miller, Michael E.
  • Nicklas, Barb
subjects:
  • Medicine
ispartof: Obesity, September 2016, Vol.24(9), pp.1861-1866
description: OBJECTIVE: A 6-month pilot trial compared two strategies for weight loss in older adults with body mass indexes (BMIs) ≥35 kg/m(2) to assess weight loss response, safety, and impact on physical function.METHODS: Twenty-eight volunteers were randomized to a balanced deficit diet (BDD) (500 kcal/day below estimated energy needs) or an intensive, low-calorie, meal replacement diet (ILCD, 960 kcal/day). Behavioral interventions and physical activity prescriptions were similar for both groups. Primary outcomes were changes in body weight and adverse event frequency; secondary outcomes included measures of physical function and body composition.RESULTS: ILCD average weight change was -19.1 ± 2.2 kg or 15.9 ± 4.6% of initial body weight compared with -9.1 ± 2.7 kg or 7.2 ± 1.9% for BDD. ILCD lost more fat mass (-7.7 kg, 95% CI [-11.9 to -3.5]) but had similar loss of lean mass (-1.7 kg, 95% CI [-4.1 to 0.6]) compared with BDD. There were no significant differences in change in physical function or adverse event frequency.CONCLUSIONS: Compared with a traditional BDD intervention, older adults who have severe obesity treated with intensive medical weight loss had greater weight loss and decreases in fat mass without a higher frequency of adverse events. In the short term, however, this did not translate into greater improvements in physical function.
language:
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identifier: ISSN: 1930-7381 ; E-ISSN: 1930-739X ; DOI: 10.1002/oby.21569
fulltext: fulltext
issn:
  • 1930-7381
  • 19307381
  • 1930-739X
  • 1930739X
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titleImpact on weight and physical function of intensive medical weight loss in older adults with stage II and III obesity
creatorArd, Jamy D. ; Cook, Miranda ; Rushing, Julia ; Frain, Annette ; Beavers, Kristen ; Miller, Gary ; Miller, Michael E. ; Nicklas, Barb
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descriptionOBJECTIVE: A 6-month pilot trial compared two strategies for weight loss in older adults with body mass indexes (BMIs) ≥35 kg/m(2) to assess weight loss response, safety, and impact on physical function.METHODS: Twenty-eight volunteers were randomized to a balanced deficit diet (BDD) (500 kcal/day below estimated energy needs) or an intensive, low-calorie, meal replacement diet (ILCD, 960 kcal/day). Behavioral interventions and physical activity prescriptions were similar for both groups. Primary outcomes were changes in body weight and adverse event frequency; secondary outcomes included measures of physical function and body composition.RESULTS: ILCD average weight change was -19.1 ± 2.2 kg or 15.9 ± 4.6% of initial body weight compared with -9.1 ± 2.7 kg or 7.2 ± 1.9% for BDD. ILCD lost more fat mass (-7.7 kg, 95% CI [-11.9 to -3.5]) but had similar loss of lean mass (-1.7 kg, 95% CI [-4.1 to 0.6]) compared with BDD. There were no significant differences in change in physical function or adverse event frequency.CONCLUSIONS: Compared with a traditional BDD intervention, older adults who have severe obesity treated with intensive medical weight loss had greater weight loss and decreases in fat mass without a higher frequency of adverse events. In the short term, however, this did not translate into greater improvements in physical function.
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