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Influence of lactic acid on degradation and biocompatibility of electrospun poly( ε ‐caprolactone) fibers

Lactic acid ()‐containing electrospun poly(‐caprolactone) () fibers show improved biocompatibility and biodegradability compared to pristine fibers. Simple conversion of into calcium lactate by Ca() treatment further improves bone compatibility of the composite fibers. Electrospinning of a poly(ε‐ca... Full description

Journal Title: Polymer International July 2014, Vol.63(7), pp.1212-1218
Main Author: Kim, Eun Kyo
Other Authors: Pant, Hem Raj , Hwang, Bo‐Sang , Kim, Yu Kyoung , Kim, Hak Yong , Lee, Kang Min , Park, Chan‐Hee , Kim, Cheol Sang
Format: Electronic Article Electronic Article
Language:
Subjects:
Pcl
ID: ISSN: 0959-8103 ; E-ISSN: 1097-0126 ; DOI: 10.1002/pi.4626
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recordid: wj10.1002/pi.4626
title: Influence of lactic acid on degradation and biocompatibility of electrospun poly( ε ‐caprolactone) fibers
format: Article
creator:
  • Kim, Eun Kyo
  • Pant, Hem Raj
  • Hwang, Bo‐Sang
  • Kim, Yu Kyoung
  • Kim, Hak Yong
  • Lee, Kang Min
  • Park, Chan‐Hee
  • Kim, Cheol Sang
subjects:
  • Pcl
  • Lactic Acid
  • Nanofibers
  • Biomaterials
  • Electrospinning
ispartof: Polymer International, July 2014, Vol.63(7), pp.1212-1218
description: Lactic acid ()‐containing electrospun poly(‐caprolactone) () fibers show improved biocompatibility and biodegradability compared to pristine fibers. Simple conversion of into calcium lactate by Ca() treatment further improves bone compatibility of the composite fibers. Electrospinning of a poly(ε‐caprolactone) (PCL)/lactic acid (LA) blend was investigated to fabricate electrospun PCL fibers with improved biodegradability and biocompatibility for biomedical applications. Simple blending of PCL solution with various amounts of LA was used for electrospinning, and the physicochemical properties of the as‐fabricated mat were evaluated using various techniques. Scanning electron microscopy showed that fiber diameter decreased with increasing amount of LA. Fourier transform infrared spectroscopy and thermogravimetric analysis also revealed that LA was successfully incorporated in PCL fibers. The presence of LA can accelerate the biodegradation of PCL fibers and enhance the hydrophilicity of a membrane. The adhesion, viability and proliferation properties of osteoblast cells on the PCL/LA composite fibers were analyzed using in vitro cell compatibility tests which showed that LA can increase the cell compatibility of PCL fibers. Additionally, subsequent conversion of LA into calcium lactate by neutralization with calcium base can provide Ca2+ ions on the fiber surface to promote the nucleation of CaPO4 particles. © 2013 Society of Chemical Industry
language:
source:
identifier: ISSN: 0959-8103 ; E-ISSN: 1097-0126 ; DOI: 10.1002/pi.4626
fulltext: fulltext
issn:
  • 0959-8103
  • 09598103
  • 1097-0126
  • 10970126
url: Link


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titleInfluence of lactic acid on degradation and biocompatibility of electrospun poly( ε ‐caprolactone) fibers
creatorKim, Eun Kyo ; Pant, Hem Raj ; Hwang, Bo‐Sang ; Kim, Yu Kyoung ; Kim, Hak Yong ; Lee, Kang Min ; Park, Chan‐Hee ; Kim, Cheol Sang
ispartofPolymer International, July 2014, Vol.63(7), pp.1212-1218
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subjectPcl ; Lactic Acid ; Nanofibers ; Biomaterials ; Electrospinning
descriptionLactic acid ()‐containing electrospun poly(‐caprolactone) () fibers show improved biocompatibility and biodegradability compared to pristine fibers. Simple conversion of into calcium lactate by Ca() treatment further improves bone compatibility of the composite fibers. Electrospinning of a poly(ε‐caprolactone) (PCL)/lactic acid (LA) blend was investigated to fabricate electrospun PCL fibers with improved biodegradability and biocompatibility for biomedical applications. Simple blending of PCL solution with various amounts of LA was used for electrospinning, and the physicochemical properties of the as‐fabricated mat were evaluated using various techniques. Scanning electron microscopy showed that fiber diameter decreased with increasing amount of LA. Fourier transform infrared spectroscopy and thermogravimetric analysis also revealed that LA was successfully incorporated in PCL fibers. The presence of LA can accelerate the biodegradation of PCL fibers and enhance the hydrophilicity of a membrane. The adhesion, viability and proliferation properties of osteoblast cells on the PCL/LA composite fibers were analyzed using in vitro cell compatibility tests which showed that LA can increase the cell compatibility of PCL fibers. Additionally, subsequent conversion of LA into calcium lactate by neutralization with calcium base can provide Ca2+ ions on the fiber surface to promote the nucleation of CaPO4 particles. © 2013 Society of Chemical Industry
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titleInfluence of lactic acid on degradation and biocompatibility of electrospun poly( ε ‐caprolactone) fibers
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abstractLactic acid ()‐containing electrospun poly(‐caprolactone) () fibers show improved biocompatibility and biodegradability compared to pristine fibers. Simple conversion of into calcium lactate by Ca() treatment further improves bone compatibility of the composite fibers. Electrospinning of a poly(ε‐caprolactone) (PCL)/lactic acid (LA) blend was investigated to fabricate electrospun PCL fibers with improved biodegradability and biocompatibility for biomedical applications. Simple blending of PCL solution with various amounts of LA was used for electrospinning, and the physicochemical properties of the as‐fabricated mat were evaluated using various techniques. Scanning electron microscopy showed that fiber diameter decreased with increasing amount of LA. Fourier transform infrared spectroscopy and thermogravimetric analysis also revealed that LA was successfully incorporated in PCL fibers. The presence of LA can accelerate the biodegradation of PCL fibers and enhance the hydrophilicity of a membrane. The adhesion, viability and proliferation properties of osteoblast cells on the PCL/LA composite fibers were analyzed using in vitro cell compatibility tests which showed that LA can increase the cell compatibility of PCL fibers. Additionally, subsequent conversion of LA into calcium lactate by neutralization with calcium base can provide Ca2+ ions on the fiber surface to promote the nucleation of CaPO4 particles. © 2013 Society of Chemical Industry
copChichester, UK
pubJohn Wiley & Sons, Ltd
doi10.1002/pi.4626
pages1212-1218
date2014-07