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Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus‐castus

Casticin (1), a flavonoid isolated from the aerial parts of , was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested for chemiluminescence, chemotaxis, T‐cell proliferation and cytotoxicity. Casticin (1) exhibited a significant inhibitory effect on monocyte oxidati... Full description

Journal Title: Phytotherapy Research November 2009, Vol.23(11), pp.1516-1520
Main Author: Mesaik, M. Ahmed
Other Authors: Azizuddin, Shahnaz , Murad, Khalid Mohammed , Khan, Rasool Bakhsh , Tareen, Aqeel , Ahmed, Muhammad Iqbal , Atta‐Ur‐Rahman, Muhammad Iqbal , Choudhary, Muhammad Iqbal
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0951-418X ; E-ISSN: 1099-1573 ; DOI: 10.1002/ptr.2492
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recordid: wj10.1002/ptr.2492
title: Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus‐castus
format: Article
creator:
  • Mesaik, M. Ahmed
  • Azizuddin, Shahnaz
  • Murad, Khalid Mohammed
  • Khan, Rasool Bakhsh
  • Tareen, Aqeel
  • Ahmed, Muhammad Iqbal
  • Atta‐Ur‐Rahman, Muhammad Iqbal
  • Choudhary, Muhammad Iqbal
subjects:
  • Vitex Agnus‐Castus
  • Verbenaceae
  • Flavonoid
  • Casticin
  • Immunomodulatory Properties
  • Monocyte Oxidative Burst Inhibition
ispartof: Phytotherapy Research, November 2009, Vol.23(11), pp.1516-1520
description: Casticin (1), a flavonoid isolated from the aerial parts of , was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested for chemiluminescence, chemotaxis, T‐cell proliferation and cytotoxicity. Casticin (1) exhibited a significant inhibitory effect on monocyte oxidative burst in a dose dependent manner. It was found to have a significant suppressive effect on the chemotaxic action at higher concentrations on fMLP (10 ) stimulated neutrophils. It also showed a potent suppressive effect on PHA stimulated T‐cell (PMBC). Copyright © 2009 John Wiley & Sons, Ltd.
language: eng
source:
identifier: ISSN: 0951-418X ; E-ISSN: 1099-1573 ; DOI: 10.1002/ptr.2492
fulltext: fulltext
issn:
  • 0951-418X
  • 0951418X
  • 1099-1573
  • 10991573
url: Link


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titleIsolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus‐castus
creatorMesaik, M. Ahmed ; Azizuddin, Shahnaz ; Murad, Khalid Mohammed ; Khan, Rasool Bakhsh ; Tareen, Aqeel ; Ahmed, Muhammad Iqbal ; Atta‐Ur‐Rahman, Muhammad Iqbal ; Choudhary, Muhammad Iqbal
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subjectVitex Agnus‐Castus ; Verbenaceae ; Flavonoid ; Casticin ; Immunomodulatory Properties ; Monocyte Oxidative Burst Inhibition
descriptionCasticin (1), a flavonoid isolated from the aerial parts of , was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested for chemiluminescence, chemotaxis, T‐cell proliferation and cytotoxicity. Casticin (1) exhibited a significant inhibitory effect on monocyte oxidative burst in a dose dependent manner. It was found to have a significant suppressive effect on the chemotaxic action at higher concentrations on fMLP (10 ) stimulated neutrophils. It also showed a potent suppressive effect on PHA stimulated T‐cell (PMBC). Copyright © 2009 John Wiley & Sons, Ltd.
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titleIsolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus‐castus
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authorMesaik, M. Ahmed ; Azizuddin, Shahnaz ; Murad, Khalid Mohammed ; Khan, Rasool Bakhsh ; Tareen, Aqeel ; Ahmed, Muhammad Iqbal ; Atta‐Ur‐Rahman, Muhammad Iqbal ; Choudhary, Muhammad Iqbal
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abstractCasticin (1), a flavonoid isolated from the aerial parts of , was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested for chemiluminescence, chemotaxis, T‐cell proliferation and cytotoxicity. Casticin (1) exhibited a significant inhibitory effect on monocyte oxidative burst in a dose dependent manner. It was found to have a significant suppressive effect on the chemotaxic action at higher concentrations on fMLP (10 ) stimulated neutrophils. It also showed a potent suppressive effect on PHA stimulated T‐cell (PMBC). Copyright © 2009 John Wiley & Sons, Ltd.
copChichester, UK
pubJohn Wiley & Sons, Ltd.
doi10.1002/ptr.2492
pages1516-1520
date2009-11