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Antiinflammatory and lipoxygenase inhibitory compounds from vitex agnus‐castus

Several secondary metabolites, artemetin (1), casticin (2), 3,3′‐dihydroxy‐5,6,7,4′‐tetramethoxy flavon (3), penduletin (4), methyl 4‐hydroxybenzoate (5), ‐hydroxybenzoic acid (6), methyl 3,4‐dihydroxybenzoate (7), 5‐hydroxy‐2‐methoxybenzoic acid (8), vanillic acid (9) and 3,4‐dihydroxybenzoic acid... Full description

Journal Title: Phytotherapy Research September 2009, Vol.23(9), pp.1336-1339
Main Author: Choudhary, M. Iqbal
Other Authors: Azizuddin, Saima , Jalil, Sarfraz Ahmad , Nawaz, Khalid Mohammed , Khan, Rasool Bakhsh , Tareen, Rasool Bakhsh , Atta‐Ur‐Rahman, Rasool Bakhsh
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0951-418X ; E-ISSN: 1099-1573 ; DOI: 10.1002/ptr.2639
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recordid: wj10.1002/ptr.2639
title: Antiinflammatory and lipoxygenase inhibitory compounds from vitex agnus‐castus
format: Article
creator:
  • Choudhary, M. Iqbal
  • Azizuddin, Saima
  • Jalil, Sarfraz Ahmad
  • Nawaz, Khalid Mohammed
  • Khan, Rasool Bakhsh
  • Tareen, Rasool Bakhsh
  • Atta‐Ur‐Rahman, Rasool Bakhsh
subjects:
  • Vitex Agnus‐Castus
  • Verbenaceae
  • Antiinflammatory Activity
  • Lipoxygenase Inhibitory Activity
  • Flavonoids
  • Phenolic Derivatives
ispartof: Phytotherapy Research, September 2009, Vol.23(9), pp.1336-1339
description: Several secondary metabolites, artemetin (1), casticin (2), 3,3′‐dihydroxy‐5,6,7,4′‐tetramethoxy flavon (3), penduletin (4), methyl 4‐hydroxybenzoate (5), ‐hydroxybenzoic acid (6), methyl 3,4‐dihydroxybenzoate (7), 5‐hydroxy‐2‐methoxybenzoic acid (8), vanillic acid (9) and 3,4‐dihydroxybenzoic acid (10) were isolated from a folkloric medicinal plant, . The structures of compounds 1–10 were identified with the help of spectroscopic techniques. Compounds 3–10 were isolated for the first time from this plant. These compounds were screened for their antiinflammatory and lipoxygenase inhibitory activities. Compounds 6, 7 and 10 were found to have significant antiinflammatory activity in a cell‐based contemporary assay, whereas compounds 1 and 2 exhibited a potent lipoxygenase inhibition. Copyright © 2009 John Wiley & Sons, Ltd.
language: eng
source:
identifier: ISSN: 0951-418X ; E-ISSN: 1099-1573 ; DOI: 10.1002/ptr.2639
fulltext: fulltext
issn:
  • 0951-418X
  • 0951418X
  • 1099-1573
  • 10991573
url: Link


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titleAntiinflammatory and lipoxygenase inhibitory compounds from vitex agnus‐castus
creatorChoudhary, M. Iqbal ; Azizuddin, Saima ; Jalil, Sarfraz Ahmad ; Nawaz, Khalid Mohammed ; Khan, Rasool Bakhsh ; Tareen, Rasool Bakhsh ; Atta‐Ur‐Rahman, Rasool Bakhsh
ispartofPhytotherapy Research, September 2009, Vol.23(9), pp.1336-1339
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subjectVitex Agnus‐Castus ; Verbenaceae ; Antiinflammatory Activity ; Lipoxygenase Inhibitory Activity ; Flavonoids ; Phenolic Derivatives
descriptionSeveral secondary metabolites, artemetin (1), casticin (2), 3,3′‐dihydroxy‐5,6,7,4′‐tetramethoxy flavon (3), penduletin (4), methyl 4‐hydroxybenzoate (5), ‐hydroxybenzoic acid (6), methyl 3,4‐dihydroxybenzoate (7), 5‐hydroxy‐2‐methoxybenzoic acid (8), vanillic acid (9) and 3,4‐dihydroxybenzoic acid (10) were isolated from a folkloric medicinal plant, . The structures of compounds 1–10 were identified with the help of spectroscopic techniques. Compounds 3–10 were isolated for the first time from this plant. These compounds were screened for their antiinflammatory and lipoxygenase inhibitory activities. Compounds 6, 7 and 10 were found to have significant antiinflammatory activity in a cell‐based contemporary assay, whereas compounds 1 and 2 exhibited a potent lipoxygenase inhibition. Copyright © 2009 John Wiley & Sons, Ltd.
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titleAntiinflammatory and lipoxygenase inhibitory compounds from vitex agnus‐castus
descriptionSeveral secondary metabolites, artemetin (1), casticin (2), 3,3′‐dihydroxy‐5,6,7,4′‐tetramethoxy flavon (3), penduletin (4), methyl 4‐hydroxybenzoate (5), ‐hydroxybenzoic acid (6), methyl 3,4‐dihydroxybenzoate (7), 5‐hydroxy‐2‐methoxybenzoic acid (8), vanillic acid (9) and 3,4‐dihydroxybenzoic acid (10) were isolated from a folkloric medicinal plant, . The structures of compounds 1–10 were identified with the help of spectroscopic techniques. Compounds 3–10 were isolated for the first time from this plant. These compounds were screened for their antiinflammatory and lipoxygenase inhibitory activities. Compounds 6, 7 and 10 were found to have significant antiinflammatory activity in a cell‐based contemporary assay, whereas compounds 1 and 2 exhibited a potent lipoxygenase inhibition. Copyright © 2009 John Wiley & Sons, Ltd.
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titleAntiinflammatory and lipoxygenase inhibitory compounds from vitex agnus‐castus
authorChoudhary, M. Iqbal ; Azizuddin, Saima ; Jalil, Sarfraz Ahmad ; Nawaz, Khalid Mohammed ; Khan, Rasool Bakhsh ; Tareen, Rasool Bakhsh ; Atta‐Ur‐Rahman, Rasool Bakhsh
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abstractSeveral secondary metabolites, artemetin (1), casticin (2), 3,3′‐dihydroxy‐5,6,7,4′‐tetramethoxy flavon (3), penduletin (4), methyl 4‐hydroxybenzoate (5), ‐hydroxybenzoic acid (6), methyl 3,4‐dihydroxybenzoate (7), 5‐hydroxy‐2‐methoxybenzoic acid (8), vanillic acid (9) and 3,4‐dihydroxybenzoic acid (10) were isolated from a folkloric medicinal plant, . The structures of compounds 1–10 were identified with the help of spectroscopic techniques. Compounds 3–10 were isolated for the first time from this plant. These compounds were screened for their antiinflammatory and lipoxygenase inhibitory activities. Compounds 6, 7 and 10 were found to have significant antiinflammatory activity in a cell‐based contemporary assay, whereas compounds 1 and 2 exhibited a potent lipoxygenase inhibition. Copyright © 2009 John Wiley & Sons, Ltd.
copChichester, UK
pubJohn Wiley & Sons, Ltd.
doi10.1002/ptr.2639
pages1336-1339
date2009-09