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Mohawk Promotes the Tenogenesis of Mesenchymal Stem Cells Through Activation of the TGFβ Signaling Pathway

The transcription factor () is expressed in developing tendons and is an important regulator of tenogenic differentiation. However, the exact roles of in tendinopathy and tendon repair remain unclear. Using gene expression Omnibus datasets and immunofluorescence assays, we found that expression leve... Full description

Journal Title: STEM CELLS February 2015, Vol.33(2), pp.443-455
Main Author: Liu, Huanhuan
Other Authors: Zhang, Can , Zhu, Shouan , Lu, Ping , Zhu, Ting , Gong, Xiaonan , Zhang, Ziwang , Hu, Jiajie , Yin, Zi , Heng, Boon Chin , Chen, Xiao , Wei Ouyang, Hong
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ID: ISSN: 1066-5099 ; E-ISSN: 1549-4918 ; DOI: 10.1002/stem.1866
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recordid: wj10.1002/stem.1866
title: Mohawk Promotes the Tenogenesis of Mesenchymal Stem Cells Through Activation of the TGFβ Signaling Pathway
format: Article
creator:
  • Liu, Huanhuan
  • Zhang, Can
  • Zhu, Shouan
  • Lu, Ping
  • Zhu, Ting
  • Gong, Xiaonan
  • Zhang, Ziwang
  • Hu, Jiajie
  • Yin, Zi
  • Heng, Boon Chin
  • Chen, Xiao
  • Wei Ouyang, Hong
subjects:
  • Mesenchymal Stem Cells
  • Tgf‐ß
  • Differentiation
  • Mohawk
  • Tendon
ispartof: STEM CELLS, February 2015, Vol.33(2), pp.443-455
description: The transcription factor () is expressed in developing tendons and is an important regulator of tenogenic differentiation. However, the exact roles of in tendinopathy and tendon repair remain unclear. Using gene expression Omnibus datasets and immunofluorescence assays, we found that expression level was dramatically lower in human tendinopathy tissue and it is activated at specific stages of tendon development. In mesenchymal stem cells (MSCs), ectopic expression strikingly promoted tenogenesis more efficiently than (), a well‐known master transcription factor of tendon. Significantly higher levels of tenogenic gene expression and collagen fibril growth were observed with versus . Interestingly, it was observed that dramatically upregulated through binding to the promoter. Additionally, the transplantation of ‐expressing‐MSC sheets promoted tendon repair in a mouse model of Achilles‐tendon defect. Taken together, these data shed light on previously unrecognized roles of in tendinopathy, tenogenesis, and tendon repair as well as in regulating the TGFβ pathway. S C
language:
source:
identifier: ISSN: 1066-5099 ; E-ISSN: 1549-4918 ; DOI: 10.1002/stem.1866
fulltext: fulltext
issn:
  • 1066-5099
  • 10665099
  • 1549-4918
  • 15494918
url: Link


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titleMohawk Promotes the Tenogenesis of Mesenchymal Stem Cells Through Activation of the TGFβ Signaling Pathway
creatorLiu, Huanhuan ; Zhang, Can ; Zhu, Shouan ; Lu, Ping ; Zhu, Ting ; Gong, Xiaonan ; Zhang, Ziwang ; Hu, Jiajie ; Yin, Zi ; Heng, Boon Chin ; Chen, Xiao ; Wei Ouyang, Hong
ispartofSTEM CELLS, February 2015, Vol.33(2), pp.443-455
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subjectMesenchymal Stem Cells ; Tgf‐ß ; Differentiation ; Mohawk ; Tendon
descriptionThe transcription factor () is expressed in developing tendons and is an important regulator of tenogenic differentiation. However, the exact roles of in tendinopathy and tendon repair remain unclear. Using gene expression Omnibus datasets and immunofluorescence assays, we found that expression level was dramatically lower in human tendinopathy tissue and it is activated at specific stages of tendon development. In mesenchymal stem cells (MSCs), ectopic expression strikingly promoted tenogenesis more efficiently than (), a well‐known master transcription factor of tendon. Significantly higher levels of tenogenic gene expression and collagen fibril growth were observed with versus . Interestingly, it was observed that dramatically upregulated through binding to the promoter. Additionally, the transplantation of ‐expressing‐MSC sheets promoted tendon repair in a mouse model of Achilles‐tendon defect. Taken together, these data shed light on previously unrecognized roles of in tendinopathy, tenogenesis, and tendon repair as well as in regulating the TGFβ pathway. S C
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titleMohawk Promotes the Tenogenesis of Mesenchymal Stem Cells Through Activation of the TGFβ Signaling Pathway
descriptionThe transcription factor () is expressed in developing tendons and is an important regulator of tenogenic differentiation. However, the exact roles of in tendinopathy and tendon repair remain unclear. Using gene expression Omnibus datasets and immunofluorescence assays, we found that expression level was dramatically lower in human tendinopathy tissue and it is activated at specific stages of tendon development. In mesenchymal stem cells (MSCs), ectopic expression strikingly promoted tenogenesis more efficiently than (), a well‐known master transcription factor of tendon. Significantly higher levels of tenogenic gene expression and collagen fibril growth were observed with versus . Interestingly, it was observed that dramatically upregulated through binding to the promoter. Additionally, the transplantation of ‐expressing‐MSC sheets promoted tendon repair in a mouse model of Achilles‐tendon defect. Taken together, these data shed light on previously unrecognized roles of in tendinopathy, tenogenesis, and tendon repair as well as in regulating the TGFβ pathway. S C
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titleMohawk Promotes the Tenogenesis of Mesenchymal Stem Cells Through Activation of the TGFβ Signaling Pathway
authorLiu, Huanhuan ; Zhang, Can ; Zhu, Shouan ; Lu, Ping ; Zhu, Ting ; Gong, Xiaonan ; Zhang, Ziwang ; Hu, Jiajie ; Yin, Zi ; Heng, Boon Chin ; Chen, Xiao ; Wei Ouyang, Hong
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abstractThe transcription factor () is expressed in developing tendons and is an important regulator of tenogenic differentiation. However, the exact roles of in tendinopathy and tendon repair remain unclear. Using gene expression Omnibus datasets and immunofluorescence assays, we found that expression level was dramatically lower in human tendinopathy tissue and it is activated at specific stages of tendon development. In mesenchymal stem cells (MSCs), ectopic expression strikingly promoted tenogenesis more efficiently than (), a well‐known master transcription factor of tendon. Significantly higher levels of tenogenic gene expression and collagen fibril growth were observed with versus . Interestingly, it was observed that dramatically upregulated through binding to the promoter. Additionally, the transplantation of ‐expressing‐MSC sheets promoted tendon repair in a mouse model of Achilles‐tendon defect. Taken together, these data shed light on previously unrecognized roles of in tendinopathy, tenogenesis, and tendon repair as well as in regulating the TGFβ pathway. S C
doi10.1002/stem.1866
pages228-234
date2015-02