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miR‐190a inhibits epithelial–mesenchymal transition of hepatoma cells via targeting the long non‐coding RNA treRNA

treRNA is a long non‐coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR‐190a can silence treRNA post‐transcriptionally. Suppression of treRNA by miR‐190a led to significant changes of mesenchymal–epithelial transition markers and impaired migration and invasion capab... Full description

Journal Title: FEBS Letters 21 December 2015, Vol.589(24PartB), pp.4079-4087
Main Author: Wang, Xinyu
Other Authors: Ren, Yanli , Yang, Xinyu , Xiong, Xiangyu , Han, Sichong , Ge, Yunxia , Pan, Wenting , Zhou, Liqing , Yuan, Qipeng , Yang, Ming
Format: Electronic Article Electronic Article
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ID: ISSN: 0014-5793 ; E-ISSN: 1873-3468 ; DOI: 10.1016/j.febslet.2015.11.024
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recordid: wj10.1016/j.febslet.2015.11.024
title: miR‐190a inhibits epithelial–mesenchymal transition of hepatoma cells via targeting the long non‐coding RNA treRNA
format: Article
creator:
  • Wang, Xinyu
  • Ren, Yanli
  • Yang, Xinyu
  • Xiong, Xiangyu
  • Han, Sichong
  • Ge, Yunxia
  • Pan, Wenting
  • Zhou, Liqing
  • Yuan, Qipeng
  • Yang, Ming
subjects:
  • Mir-190a
  • Long Non-Coding Rna
  • Translation Regulatory Long Non-Coding Rna
  • Hepatoma
  • Epithelial-To-Mesenchymal Transition
ispartof: FEBS Letters, 21 December 2015, Vol.589(24PartB), pp.4079-4087
description: treRNA is a long non‐coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR‐190a can silence treRNA post‐transcriptionally. Suppression of treRNA by miR‐190a led to significant changes of mesenchymal–epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR‐190a exhibited lower expression in hepatoma tissues, especially from patients with vascular tumor invasion, compared to normal tissues. Our results reveal the involvement of miR‐190a–treRNA axis in hepatoma progression and shed light on lncRNA‐based cancer therapies for hepatoma patients at high risk of metastasis. We identified a novel layer of treRNA regulation. miR‐190a inhibits hepatoma migration and invasion by silencing of treRNA. miR‐190a negatively regulates treRNA as a tumor suppressor in hepatoma.
language:
source:
identifier: ISSN: 0014-5793 ; E-ISSN: 1873-3468 ; DOI: 10.1016/j.febslet.2015.11.024
fulltext: fulltext
issn:
  • 0014-5793
  • 00145793
  • 1873-3468
  • 18733468
url: Link


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titlemiR‐190a inhibits epithelial–mesenchymal transition of hepatoma cells via targeting the long non‐coding RNA treRNA
creatorWang, Xinyu ; Ren, Yanli ; Yang, Xinyu ; Xiong, Xiangyu ; Han, Sichong ; Ge, Yunxia ; Pan, Wenting ; Zhou, Liqing ; Yuan, Qipeng ; Yang, Ming
ispartofFEBS Letters, 21 December 2015, Vol.589(24PartB), pp.4079-4087
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subjectMir-190a ; Long Non-Coding Rna ; Translation Regulatory Long Non-Coding Rna ; Hepatoma ; Epithelial-To-Mesenchymal Transition
descriptiontreRNA is a long non‐coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR‐190a can silence treRNA post‐transcriptionally. Suppression of treRNA by miR‐190a led to significant changes of mesenchymal–epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR‐190a exhibited lower expression in hepatoma tissues, especially from patients with vascular tumor invasion, compared to normal tissues. Our results reveal the involvement of miR‐190a–treRNA axis in hepatoma progression and shed light on lncRNA‐based cancer therapies for hepatoma patients at high risk of metastasis. We identified a novel layer of treRNA regulation. miR‐190a inhibits hepatoma migration and invasion by silencing of treRNA. miR‐190a negatively regulates treRNA as a tumor suppressor in hepatoma.
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titlemiR‐190a inhibits epithelial–mesenchymal transition of hepatoma cells via targeting the long non‐coding RNA treRNA
descriptiontreRNA is a long non‐coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR‐190a can silence treRNA post‐transcriptionally. Suppression of treRNA by miR‐190a led to significant changes of mesenchymal–epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR‐190a exhibited lower expression in hepatoma tissues, especially from patients with vascular tumor invasion, compared to normal tissues. Our results reveal the involvement of miR‐190a–treRNA axis in hepatoma progression and shed light on lncRNA‐based cancer therapies for hepatoma patients at high risk of metastasis. We identified a novel layer of treRNA regulation. miR‐190a inhibits hepatoma migration and invasion by silencing of treRNA. miR‐190a negatively regulates treRNA as a tumor suppressor in hepatoma.
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titlemiR‐190a inhibits epithelial–mesenchymal transition of hepatoma cells via targeting the long non‐coding RNA treRNA
authorWang, Xinyu ; Ren, Yanli ; Yang, Xinyu ; Xiong, Xiangyu ; Han, Sichong ; Ge, Yunxia ; Pan, Wenting ; Zhou, Liqing ; Yuan, Qipeng ; Yang, Ming
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abstracttreRNA is a long non‐coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR‐190a can silence treRNA post‐transcriptionally. Suppression of treRNA by miR‐190a led to significant changes of mesenchymal–epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR‐190a exhibited lower expression in hepatoma tissues, especially from patients with vascular tumor invasion, compared to normal tissues. Our results reveal the involvement of miR‐190a–treRNA axis in hepatoma progression and shed light on lncRNA‐based cancer therapies for hepatoma patients at high risk of metastasis. We identified a novel layer of treRNA regulation. miR‐190a inhibits hepatoma migration and invasion by silencing of treRNA. miR‐190a negatively regulates treRNA as a tumor suppressor in hepatoma.
doi10.1016/j.febslet.2015.11.024
pages4079-4087
date2015-12-21