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Discovery and distribution of super‐integrons among Pseudomonads

Until recently, integrons (systems for acquisition and expression of new genetic materials) have been associated generally with antibiotic resistance gene cassettes. The discovery of ‘super‐integrons’ in suggests a greater impact of this gene acquisition mechanism on bacterial genome evolution than... Full description

Journal Title: Molecular Microbiology November 2001, Vol.42(3), pp.587-601
Main Author: Vaisvila, Romualdas
Other Authors: Morgan, Richard D. , Posfai, Janos , Raleigh, Elisabeth A.
Format: Electronic Article Electronic Article
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ID: ISSN: 0950-382X ; E-ISSN: 1365-2958 ; DOI: 10.1046/j.1365-2958.2001.02604.x
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recordid: wj10.1046/j.1365-2958.2001.02604.x
title: Discovery and distribution of super‐integrons among Pseudomonads
format: Article
creator:
  • Vaisvila, Romualdas
  • Morgan, Richard D.
  • Posfai, Janos
  • Raleigh, Elisabeth A.
subjects:
  • Biology
ispartof: Molecular Microbiology, November 2001, Vol.42(3), pp.587-601
description: Until recently, integrons (systems for acquisition and expression of new genetic materials) have been associated generally with antibiotic resistance gene cassettes. The discovery of ‘super‐integrons’ in suggests a greater impact of this gene acquisition mechanism on bacterial genome evolution than initially believed. Super‐integrons may contain more than 100 gene cassettes and may encode other determinants, including biochemical functions or virulence factors. Here, we report the genetic organization of a super‐integron from ATCC 55044. This is the first evidence of a super‐integron in a non‐pathogenic bacterium, one which is widely distributed in a great number of ecological niches such as soil and aquatic habitats. Here, the sequence composition, open reading frame (ORF) content and organization of In55044 are described and found to have features intermediate between the multidrug‐resistant integrons and the super‐integron. Similar structures are inferred to be present in several species, based on polymerase chain reaction (PCR) experiments.
language:
source:
identifier: ISSN: 0950-382X ; E-ISSN: 1365-2958 ; DOI: 10.1046/j.1365-2958.2001.02604.x
fulltext: fulltext
issn:
  • 0950-382X
  • 0950382X
  • 1365-2958
  • 13652958
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descriptionUntil recently, integrons (systems for acquisition and expression of new genetic materials) have been associated generally with antibiotic resistance gene cassettes. The discovery of ‘super‐integrons’ in suggests a greater impact of this gene acquisition mechanism on bacterial genome evolution than initially believed. Super‐integrons may contain more than 100 gene cassettes and may encode other determinants, including biochemical functions or virulence factors. Here, we report the genetic organization of a super‐integron from ATCC 55044. This is the first evidence of a super‐integron in a non‐pathogenic bacterium, one which is widely distributed in a great number of ecological niches such as soil and aquatic habitats. Here, the sequence composition, open reading frame (ORF) content and organization of In55044 are described and found to have features intermediate between the multidrug‐resistant integrons and the super‐integron. Similar structures are inferred to be present in several species, based on polymerase chain reaction (PCR) experiments.
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descriptionUntil recently, integrons (systems for acquisition and expression of new genetic materials) have been associated generally with antibiotic resistance gene cassettes. The discovery of ‘super‐integrons’ in suggests a greater impact of this gene acquisition mechanism on bacterial genome evolution than initially believed. Super‐integrons may contain more than 100 gene cassettes and may encode other determinants, including biochemical functions or virulence factors. Here, we report the genetic organization of a super‐integron from ATCC 55044. This is the first evidence of a super‐integron in a non‐pathogenic bacterium, one which is widely distributed in a great number of ecological niches such as soil and aquatic habitats. Here, the sequence composition, open reading frame (ORF) content and organization of In55044 are described and found to have features intermediate between the multidrug‐resistant integrons and the super‐integron. Similar structures are inferred to be present in several species, based on polymerase chain reaction (PCR) experiments.
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abstractUntil recently, integrons (systems for acquisition and expression of new genetic materials) have been associated generally with antibiotic resistance gene cassettes. The discovery of ‘super‐integrons’ in suggests a greater impact of this gene acquisition mechanism on bacterial genome evolution than initially believed. Super‐integrons may contain more than 100 gene cassettes and may encode other determinants, including biochemical functions or virulence factors. Here, we report the genetic organization of a super‐integron from ATCC 55044. This is the first evidence of a super‐integron in a non‐pathogenic bacterium, one which is widely distributed in a great number of ecological niches such as soil and aquatic habitats. Here, the sequence composition, open reading frame (ORF) content and organization of In55044 are described and found to have features intermediate between the multidrug‐resistant integrons and the super‐integron. Similar structures are inferred to be present in several species, based on polymerase chain reaction (PCR) experiments.
copOxford, UK
pubBlackwell Science Ltd
doi10.1046/j.1365-2958.2001.02604.x
pages587-601
date2001-11