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Potential biomarkers in patients with systemic sclerosis

Byline: Andrea Delle Sedie, Lucrezia Riente, Lavinia Maggiorini, Federico Pratesi, Antonio Tavoni,Paola Migliorini, Ilaria Puxeddu Keywords: adhesion molecules; angiogenesis; elastase; endostatin; systemic sclerosis Abstract Aim Reduced capillary density is considered the hallmark of systemic sclero... Full description

Journal Title: International Journal of Rheumatic Diseases January 2018, Vol.21(1), pp.261-265
Main Author: Delle Sedie, Andrea
Other Authors: Riente, Lucrezia , Maggiorini, Lavinia , Pratesi, Federico , Tavoni, Antonio , Migliorini, Paola , Puxeddu, Ilaria
Format: Electronic Article Electronic Article
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ID: ISSN: 1756-1841 ; E-ISSN: 1756-185X ; DOI: 10.1111/1756-185X.13196
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recordid: wj10.1111/1756-185X.13196
title: Potential biomarkers in patients with systemic sclerosis
format: Article
creator:
  • Delle Sedie, Andrea
  • Riente, Lucrezia
  • Maggiorini, Lavinia
  • Pratesi, Federico
  • Tavoni, Antonio
  • Migliorini, Paola
  • Puxeddu, Ilaria
subjects:
  • Adhesion Molecules
  • Angiogenesis
  • Elastase
  • Endostatin
  • Systemic Sclerosis
ispartof: International Journal of Rheumatic Diseases, January 2018, Vol.21(1), pp.261-265
description: Byline: Andrea Delle Sedie, Lucrezia Riente, Lavinia Maggiorini, Federico Pratesi, Antonio Tavoni,Paola Migliorini, Ilaria Puxeddu Keywords: adhesion molecules; angiogenesis; elastase; endostatin; systemic sclerosis Abstract Aim Reduced capillary density is considered the hallmark of systemic sclerosis (SSc) leads to tissue hypoxia, a condition that usually induces angiogenesis. The objective of our study is to investigate mediators regulating angiogenesis in SSc and to correlate their levels with serological and clinical parameters. Methods vascular endothelial growth factor, fibroblast growth factor-2, endostatin, thrombospondin-1 and soluble vascular cell and intracellular adhesion molecules (sICAM-1 and sVCAM-1) were measured in sera of SSc and normal subjects by enzyme-linked immunosorbent assay. Results Among the pro- and anti-angiogenic mediators, endostatin was significantly higher in SSc than in the control subjects. Out of the proteases involved in endostatin production, elastase but not cathepsin-L, was significantly increased in SSc patients. The soluble adhesion molecules sICAM-1 and sVCAM-1 were significantly increased and they occur in parallel. sICAM-1, but not sVCAM-1 positively correlates with the inflammatory markers C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Conclusions Endostatin, elastase and the soluble adhesion molecules (sICAM-1 and sVCAM-1) are potentially involved in the pathogenesis of SSc. Moreover, the significant correlation observed between sICAM-1 and CRP and ESR indicates that sICAM-1 might be a useful biomarker of the inflammatory state of the disease.
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identifier: ISSN: 1756-1841 ; E-ISSN: 1756-185X ; DOI: 10.1111/1756-185X.13196
fulltext: fulltext
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  • 1756-1841
  • 17561841
  • 1756-185X
  • 1756185X
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titlePotential biomarkers in patients with systemic sclerosis
creatorDelle Sedie, Andrea ; Riente, Lucrezia ; Maggiorini, Lavinia ; Pratesi, Federico ; Tavoni, Antonio ; Migliorini, Paola ; Puxeddu, Ilaria
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descriptionByline: Andrea Delle Sedie, Lucrezia Riente, Lavinia Maggiorini, Federico Pratesi, Antonio Tavoni,Paola Migliorini, Ilaria Puxeddu Keywords: adhesion molecules; angiogenesis; elastase; endostatin; systemic sclerosis Abstract Aim Reduced capillary density is considered the hallmark of systemic sclerosis (SSc) leads to tissue hypoxia, a condition that usually induces angiogenesis. The objective of our study is to investigate mediators regulating angiogenesis in SSc and to correlate their levels with serological and clinical parameters. Methods vascular endothelial growth factor, fibroblast growth factor-2, endostatin, thrombospondin-1 and soluble vascular cell and intracellular adhesion molecules (sICAM-1 and sVCAM-1) were measured in sera of SSc and normal subjects by enzyme-linked immunosorbent assay. Results Among the pro- and anti-angiogenic mediators, endostatin was significantly higher in SSc than in the control subjects. Out of the proteases involved in endostatin production, elastase but not cathepsin-L, was significantly increased in SSc patients. The soluble adhesion molecules sICAM-1 and sVCAM-1 were significantly increased and they occur in parallel. sICAM-1, but not sVCAM-1 positively correlates with the inflammatory markers C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Conclusions Endostatin, elastase and the soluble adhesion molecules (sICAM-1 and sVCAM-1) are potentially involved in the pathogenesis of SSc. Moreover, the significant correlation observed between sICAM-1 and CRP and ESR indicates that sICAM-1 might be a useful biomarker of the inflammatory state of the disease.
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