schliessen

Filtern

 

Bibliotheken

Neonatal folate, homocysteine, vitamin B 12 levels and methylenetetrahydrofolate reductase variants in childhood asthma and eczema

Byline: R. J. P. Valk, J. C. Kiefte-de Jong, A. M. M. Sonnenschein-van der Voort, L. Duijts, E. Hafkamp-de Groen, H. A. Moll, H. Tiemeier, E. A. P. Steegers, A. Hofman, V. W. V. Jaddoe, J. C. Jongste Keywords: asthma; eczema; folate; homocysteine; MTHFR Abstract Objectives To assess the associations... Full description

Journal Title: Allergy June 2013, Vol.68(6), pp.788-795
Main Author: Valk, R. J. P.
Other Authors: Kiefte‐De Jong, J. C. , Sonnenschein‐Van Der Voort, A. M. M. , Duijts, L. , Hafkamp‐De Groen, E. , Moll, H. A. , Tiemeier, H. , Steegers, E. A. P. , Hofman, A. , Jaddoe, V. W. V. , Jongste, J. C.
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0105-4538 ; E-ISSN: 1398-9995 ; DOI: 10.1111/all.12146
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: wj10.1111/all.12146
title: Neonatal folate, homocysteine, vitamin B 12 levels and methylenetetrahydrofolate reductase variants in childhood asthma and eczema
format: Article
creator:
  • Valk, R. J. P.
  • Kiefte‐De Jong, J. C.
  • Sonnenschein‐Van Der Voort, A. M. M.
  • Duijts, L.
  • Hafkamp‐De Groen, E.
  • Moll, H. A.
  • Tiemeier, H.
  • Steegers, E. A. P.
  • Hofman, A.
  • Jaddoe, V. W. V.
  • Jongste, J. C.
subjects:
  • Asthma
  • Eczema
  • Folate
  • Homocysteine
  • Mthfr
ispartof: Allergy, June 2013, Vol.68(6), pp.788-795
description: Byline: R. J. P. Valk, J. C. Kiefte-de Jong, A. M. M. Sonnenschein-van der Voort, L. Duijts, E. Hafkamp-de Groen, H. A. Moll, H. Tiemeier, E. A. P. Steegers, A. Hofman, V. W. V. Jaddoe, J. C. Jongste Keywords: asthma; eczema; folate; homocysteine; MTHFR Abstract Objectives To assess the associations of folate, homocysteine and vitamin B12 levels of children at birth and their methylenetetrahydrofolate reductase (MTHFR) variants with asthma and eczema in childhood. Methods This study was embedded in a population-based prospective cohort study (n = 2,001). Neonatal cord blood folate, homocysteine and vitamin B12 levels were measured, and MTHFR C677T and A1298C genotyped. Wheezing and physician-diagnosed eczema were annually obtained by questionnaire until 4 years. At 6 years, we collected information on physician-diagnosed asthma ever and self-reported eczema ever, measured fractional exhaled nitric oxide (FeNO), and interrupter resistance (Rint). Data were analysed with generalized estimating equations or logistic regression: continuous outcomes with linear regression models. Results Folate, homocysteine and vitamin B12 levels of children at birth were not associated with wheezing or eczema until 4 years, asthma and eczema ever, or FeNO or Rint at 6 years. In children carrying C677T mutations in MTHFR, higher folate levels were associated with an increased risk of eczema (repeated eczema until 4 years: OR 1.40 (95% CI 1.09-1.80) (SD change) P-interaction = 0.003, eczema ever at 6 years: OR 1.41 (0.97-2.03) P-interaction = 0.011). No interactions between MTHFR and child folate and homocysteine levels were observed for wheezing and asthma. Conclusions Folate, homocysteine and vitamin B12 levels of children at birth did not affect asthma- and eczema-related outcomes up to the age of 6 years. Further studies are warranted to establish the role of MTHFR variants in these associations. Author Affiliation: Article Note: Edited by: Stephan Weidinger Supporting information: Additional Supporting Information may be found in the online version of this article
language:
source:
identifier: ISSN: 0105-4538 ; E-ISSN: 1398-9995 ; DOI: 10.1111/all.12146
fulltext: fulltext
issn:
  • 0105-4538
  • 01054538
  • 1398-9995
  • 13989995
url: Link


@attributes
ID306776976
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1111/all.12146
sourceidwj
recordidTN_wj10.1111/all.12146
sourcesystemPC
pqid1367490340
galeid330705978
display
typearticle
titleNeonatal folate, homocysteine, vitamin B 12 levels and methylenetetrahydrofolate reductase variants in childhood asthma and eczema
creatorValk, R. J. P. ; Kiefte‐De Jong, J. C. ; Sonnenschein‐Van Der Voort, A. M. M. ; Duijts, L. ; Hafkamp‐De Groen, E. ; Moll, H. A. ; Tiemeier, H. ; Steegers, E. A. P. ; Hofman, A. ; Jaddoe, V. W. V. ; Jongste, J. C.
ispartofAllergy, June 2013, Vol.68(6), pp.788-795
identifier
subjectAsthma ; Eczema ; Folate ; Homocysteine ; Mthfr
source
descriptionByline: R. J. P. Valk, J. C. Kiefte-de Jong, A. M. M. Sonnenschein-van der Voort, L. Duijts, E. Hafkamp-de Groen, H. A. Moll, H. Tiemeier, E. A. P. Steegers, A. Hofman, V. W. V. Jaddoe, J. C. Jongste Keywords: asthma; eczema; folate; homocysteine; MTHFR Abstract Objectives To assess the associations of folate, homocysteine and vitamin B12 levels of children at birth and their methylenetetrahydrofolate reductase (MTHFR) variants with asthma and eczema in childhood. Methods This study was embedded in a population-based prospective cohort study (n = 2,001). Neonatal cord blood folate, homocysteine and vitamin B12 levels were measured, and MTHFR C677T and A1298C genotyped. Wheezing and physician-diagnosed eczema were annually obtained by questionnaire until 4 years. At 6 years, we collected information on physician-diagnosed asthma ever and self-reported eczema ever, measured fractional exhaled nitric oxide (FeNO), and interrupter resistance (Rint). Data were analysed with generalized estimating equations or logistic regression: continuous outcomes with linear regression models. Results Folate, homocysteine and vitamin B12 levels of children at birth were not associated with wheezing or eczema until 4 years, asthma and eczema ever, or FeNO or Rint at 6 years. In children carrying C677T mutations in MTHFR, higher folate levels were associated with an increased risk of eczema (repeated eczema until 4 years: OR 1.40 (95% CI 1.09-1.80) (SD change) P-interaction = 0.003, eczema ever at 6 years: OR 1.41 (0.97-2.03) P-interaction = 0.011). No interactions between MTHFR and child folate and homocysteine levels were observed for wheezing and asthma. Conclusions Folate, homocysteine and vitamin B12 levels of children at birth did not affect asthma- and eczema-related outcomes up to the age of 6 years. Further studies are warranted to establish the role of MTHFR variants in these associations. Author Affiliation: Article Note: Edited by: Stephan Weidinger Supporting information: Additional Supporting Information may be found in the online version of this article
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Valk, R. J. P.
1Kiefte‐De Jong, J. C.
2Sonnenschein‐Van Der Voort, A. M. M.
3Duijts, L.
4Hafkamp‐De Groen, E.
5Moll, H. A.
6Tiemeier, H.
7Steegers, E. A. P.
8Hofman, A.
9Jaddoe, V. W. V.
10Jongste, J. C.
titleNeonatal folate, homocysteine, vitamin B 12 levels and methylenetetrahydrofolate reductase variants in childhood asthma and eczema
subject
0Asthma
1Eczema
2Folate
3Homocysteine
4Mthfr
general
010.1111/all.12146
1Wiley Online Library
sourceidwj
recordidwj10.1111/all.12146
issn
00105-4538
101054538
21398-9995
313989995
rsrctypearticle
creationdate2013
addtitleAllergy
searchscope
0wj
1wiley
scope
0wj
1wiley
lsr30VSR-Enriched:[pages, pqid, galeid, description]
sort
titleNeonatal folate, homocysteine, vitamin B 12 levels and methylenetetrahydrofolate reductase variants in childhood asthma and eczema
authorValk, R. J. P. ; Kiefte‐De Jong, J. C. ; Sonnenschein‐Van Der Voort, A. M. M. ; Duijts, L. ; Hafkamp‐De Groen, E. ; Moll, H. A. ; Tiemeier, H. ; Steegers, E. A. P. ; Hofman, A. ; Jaddoe, V. W. V. ; Jongste, J. C.
creationdate20130600
facets
frbrgroupid8257967165755406922
frbrtype5
creationdate2013
topic
0Asthma
1Eczema
2Folate
3Homocysteine
4Mthfr
collectionWiley Online Library
prefilterarticles
rsrctypearticles
creatorcontrib
0Valk, R. J. P.
1Kiefte‐De Jong, J. C.
2Sonnenschein‐Van Der Voort, A. M. M.
3Duijts, L.
4Hafkamp‐De Groen, E.
5Moll, H. A.
6Tiemeier, H.
7Steegers, E. A. P.
8Hofman, A.
9Jaddoe, V. W. V.
10Jongste, J. C.
jtitleAllergy
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Valk
1Kiefte‐de Jong
2Sonnenschein‐van der Voort
3Duijts
4Hafkamp‐de Groen
5Moll
6Tiemeier
7Steegers
8Hofman
9Jaddoe
10Jongste
aufirst
0R. J. P.
1J. C.
2A. M. M.
3L.
4E.
5H. A.
6H.
7E. A. P.
8A.
9V. W. V.
au
0Valk, R. J. P.
1Kiefte‐De Jong, J. C.
2Sonnenschein‐Van Der Voort, A. M. M.
3Duijts, L.
4Hafkamp‐De Groen, E.
5Moll, H. A.
6Tiemeier, H.
7Steegers, E. A. P.
8Hofman, A.
9Jaddoe, V. W. V.
10Jongste, J. C.
atitleNeonatal folate, homocysteine, vitamin B 12 levels and methylenetetrahydrofolate reductase variants in childhood asthma and eczema
jtitleAllergy
risdate201306
volume68
issue6
spage788
epage795
issn0105-4538
eissn1398-9995
genrearticle
ristypeJOUR
doi10.1111/all.12146
pages788-795
date2013-06