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Joint effect of glutathione S‐transferase genotypes and cigarette smoking on idiopathic male infertility

Inconsistent results of association studies investigated the role of glutathione S–transferase genes in idiopathic male infertility may be explained by ethnical differences in gene–gene and gene–environment interactions. In this study, we investigated a joint contribution of , and gene polymorphisms... Full description

Journal Title: Andrologia November 2015, Vol.47(9), pp.980-986
Main Author: Yarosh, S. L.
Other Authors: Kokhtenko, E. V. , Churnosov, M. I. , Solodilova, M. A. , Polonikov, A. V.
Format: Electronic Article Electronic Article
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ID: ISSN: 0303-4569 ; E-ISSN: 1439-0272 ; DOI: 10.1111/and.12367
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recordid: wj10.1111/and.12367
title: Joint effect of glutathione S‐transferase genotypes and cigarette smoking on idiopathic male infertility
format: Article
creator:
  • Yarosh, S. L.
  • Kokhtenko, E. V.
  • Churnosov, M. I.
  • Solodilova, M. A.
  • Polonikov, A. V.
subjects:
  • Cigarette Smoking
  • Gene–Environment Interactions
  • Gene–Gene Interactions
  • Glutathione S‐Transferase
  • Idiopathic Male Infertility
ispartof: Andrologia, November 2015, Vol.47(9), pp.980-986
description: Inconsistent results of association studies investigated the role of glutathione S–transferase genes in idiopathic male infertility may be explained by ethnical differences in gene–gene and gene–environment interactions. In this study, we investigated a joint contribution of , and gene polymorphisms and cigarette smoking to the risk of idiopathic infertility in Russian men. samples from 203 infertile and 227 fertile men were genotyped by a multiplex polymerase chain reaction ( and deletions) and ‐restriction fragment length polymorphism ( I105V) methods. The genotype 105 was associated with increased risk of male infertility ( = 1.50 95% 1.02–2.20 =0.04). Genotype combinations 105/ del (G1), del/ del (G2) and + / del (G3) were associated with decreased risk of male infertility (≤0.003), whereas a genotype combination 105/ + (G4) was associated with increased disease risk (=0.001). The genotype combinations G3 and G4 showed a significant association with infertility in smokers; however, nonsmokers carriers did show the disease risk. In conclusion, , and genes are collectively involved in the development of idiopathic male infertility and their phenotypic effects on the disease risk are potentiated by cigarette smoking.
language:
source:
identifier: ISSN: 0303-4569 ; E-ISSN: 1439-0272 ; DOI: 10.1111/and.12367
fulltext: fulltext
issn:
  • 0303-4569
  • 03034569
  • 1439-0272
  • 14390272
url: Link


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titleJoint effect of glutathione S‐transferase genotypes and cigarette smoking on idiopathic male infertility
creatorYarosh, S. L. ; Kokhtenko, E. V. ; Churnosov, M. I. ; Solodilova, M. A. ; Polonikov, A. V.
ispartofAndrologia, November 2015, Vol.47(9), pp.980-986
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subjectCigarette Smoking ; Gene–Environment Interactions ; Gene–Gene Interactions ; Glutathione S‐Transferase ; Idiopathic Male Infertility
descriptionInconsistent results of association studies investigated the role of glutathione S–transferase genes in idiopathic male infertility may be explained by ethnical differences in gene–gene and gene–environment interactions. In this study, we investigated a joint contribution of , and gene polymorphisms and cigarette smoking to the risk of idiopathic infertility in Russian men. samples from 203 infertile and 227 fertile men were genotyped by a multiplex polymerase chain reaction ( and deletions) and ‐restriction fragment length polymorphism ( I105V) methods. The genotype 105 was associated with increased risk of male infertility ( = 1.50 95% 1.02–2.20 =0.04). Genotype combinations 105/ del (G1), del/ del (G2) and + / del (G3) were associated with decreased risk of male infertility (≤0.003), whereas a genotype combination 105/ + (G4) was associated with increased disease risk (=0.001). The genotype combinations G3 and G4 showed a significant association with infertility in smokers; however, nonsmokers carriers did show the disease risk. In conclusion, , and genes are collectively involved in the development of idiopathic male infertility and their phenotypic effects on the disease risk are potentiated by cigarette smoking.
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titleJoint effect of glutathione S‐transferase genotypes and cigarette smoking on idiopathic male infertility
descriptionInconsistent results of association studies investigated the role of glutathione S–transferase genes in idiopathic male infertility may be explained by ethnical differences in gene–gene and gene–environment interactions. In this study, we investigated a joint contribution of , and gene polymorphisms and cigarette smoking to the risk of idiopathic infertility in Russian men. samples from 203 infertile and 227 fertile men were genotyped by a multiplex polymerase chain reaction ( and deletions) and ‐restriction fragment length polymorphism ( I105V) methods. The genotype 105 was associated with increased risk of male infertility ( = 1.50 95% 1.02–2.20 =0.04). Genotype combinations 105/ del (G1), del/ del (G2) and + / del (G3) were associated with decreased risk of male infertility (≤0.003), whereas a genotype combination 105/ + (G4) was associated with increased disease risk (=0.001). The genotype combinations G3 and G4 showed a significant association with infertility in smokers; however, nonsmokers carriers did show the disease risk. In conclusion, , and genes are collectively involved in the development of idiopathic male infertility and their phenotypic effects on the disease risk are potentiated by cigarette smoking.
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titleJoint effect of glutathione S‐transferase genotypes and cigarette smoking on idiopathic male infertility
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abstractInconsistent results of association studies investigated the role of glutathione S–transferase genes in idiopathic male infertility may be explained by ethnical differences in gene–gene and gene–environment interactions. In this study, we investigated a joint contribution of , and gene polymorphisms and cigarette smoking to the risk of idiopathic infertility in Russian men. samples from 203 infertile and 227 fertile men were genotyped by a multiplex polymerase chain reaction ( and deletions) and ‐restriction fragment length polymorphism ( I105V) methods. The genotype 105 was associated with increased risk of male infertility ( = 1.50 95% 1.02–2.20 =0.04). Genotype combinations 105/ del (G1), del/ del (G2) and + / del (G3) were associated with decreased risk of male infertility (≤0.003), whereas a genotype combination 105/ + (G4) was associated with increased disease risk (=0.001). The genotype combinations G3 and G4 showed a significant association with infertility in smokers; however, nonsmokers carriers did show the disease risk. In conclusion, , and genes are collectively involved in the development of idiopathic male infertility and their phenotypic effects on the disease risk are potentiated by cigarette smoking.
doi10.1111/and.12367
pages980-986
date2015-11