schliessen

Filtern

 

Bibliotheken

Role(s) of Leader protein of Saffold virus

To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/cen3.12109/abstract Byline: Ai Shimizu, Toshiki Himeda, Takako Okuwa, Yasushi Muraki, Yoshiro Ohara Keywords: anti-interferon response; Leader protein; Saffold virus Abstr... Full description

Journal Title: Clinical and Experimental Neuroimmunology October 2014, Vol.5(3), pp.362-366
Main Author: Shimizu, Ai
Other Authors: Himeda, Toshiki , Okuwa, Takako , Muraki, Yasushi , Ohara, Yoshiro
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 1759-1961 ; E-ISSN: 1759-1961 ; DOI: 10.1111/cen3.12109
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: wj10.1111/cen3.12109
title: Role(s) of Leader protein of Saffold virus
format: Article
creator:
  • Shimizu, Ai
  • Himeda, Toshiki
  • Okuwa, Takako
  • Muraki, Yasushi
  • Ohara, Yoshiro
subjects:
  • Anti‐Interferon Response
  • Leader Protein
  • Saffold Virus
ispartof: Clinical and Experimental Neuroimmunology, October 2014, Vol.5(3), pp.362-366
description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/cen3.12109/abstract Byline: Ai Shimizu, Toshiki Himeda, Takako Okuwa, Yasushi Muraki, Yoshiro Ohara Keywords: anti-interferon response; Leader protein; Saffold virus Abstract Objective Saffold virus (SAFV) classified in the species Theilovirus of the genus Cardiovirus is a novel human cardiovirus. The pathogenicity of SAFV in humans still remains unclear. Viruses in the genus Cardiovirus produce Leader protein, which is a small non-structural protein. Evidence that Leader protein of murine cardioviruses is a key factor in their biological activities has been provided. Therefore, the studies on the function of SAFV-L are likely to be important in order to clarify the pathogenicity of SAFV. Methods We investigated the interferon (IFN) response in the early stage of SAFV infection by reverse transcription polymerase chain reaction and the growth kinetics of the chimera virus, SAFL/DA. Results The study showed that SAFV-L suppresses the type I IFN response, and that the responsible region of anti-IFN activity of SAFV-L is a zinc-binding motif. Furthermore, the anti-apoptotic activity of SAFV-L was suggested from the growth kinetics analysis of SAFL/DA. Conclusions The present study suggested that SAFV-L might be a multifunctional protein; for example, the suppression of IFN induction, anti-apoptotic effect and/or productive virus growth.
language:
source:
identifier: ISSN: 1759-1961 ; E-ISSN: 1759-1961 ; DOI: 10.1111/cen3.12109
fulltext: fulltext
issn:
  • 1759-1961
  • 17591961
url: Link


@attributes
ID1673785354
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1111/cen3.12109
sourceidwj
recordidTN_wj10.1111/cen3.12109
sourcesystemOther
pqid1566689932
galeid397932391
display
typearticle
titleRole(s) of Leader protein of Saffold virus
creatorShimizu, Ai ; Himeda, Toshiki ; Okuwa, Takako ; Muraki, Yasushi ; Ohara, Yoshiro
ispartofClinical and Experimental Neuroimmunology, October 2014, Vol.5(3), pp.362-366
identifier
subjectAnti‐Interferon Response ; Leader Protein ; Saffold Virus
source
descriptionTo purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/cen3.12109/abstract Byline: Ai Shimizu, Toshiki Himeda, Takako Okuwa, Yasushi Muraki, Yoshiro Ohara Keywords: anti-interferon response; Leader protein; Saffold virus Abstract Objective Saffold virus (SAFV) classified in the species Theilovirus of the genus Cardiovirus is a novel human cardiovirus. The pathogenicity of SAFV in humans still remains unclear. Viruses in the genus Cardiovirus produce Leader protein, which is a small non-structural protein. Evidence that Leader protein of murine cardioviruses is a key factor in their biological activities has been provided. Therefore, the studies on the function of SAFV-L are likely to be important in order to clarify the pathogenicity of SAFV. Methods We investigated the interferon (IFN) response in the early stage of SAFV infection by reverse transcription polymerase chain reaction and the growth kinetics of the chimera virus, SAFL/DA. Results The study showed that SAFV-L suppresses the type I IFN response, and that the responsible region of anti-IFN activity of SAFV-L is a zinc-binding motif. Furthermore, the anti-apoptotic activity of SAFV-L was suggested from the growth kinetics analysis of SAFL/DA. Conclusions The present study suggested that SAFV-L might be a multifunctional protein; for example, the suppression of IFN induction, anti-apoptotic effect and/or productive virus growth.
version4
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Shimizu, Ai
1Himeda, Toshiki
2Okuwa, Takako
3Muraki, Yasushi
4Ohara, Yoshiro
titleRole(s) of Leader protein of Saffold virus
subject
0Anti‐Interferon Response
1Leader Protein
2Saffold Virus
general
010.1111/cen3.12109
1Wiley Online Library
sourceidwj
recordidwj10.1111/cen3.12109
issn
01759-1961
117591961
rsrctypearticle
creationdate2014
addtitle
0Clinical and Experimental Neuroimmunology
1Clin Exp Neuroimmunol
searchscope
0wj
1wiley
scope
0wj
1wiley
lsr30VSR-Enriched:[pqid, pages, galeid, description]
sort
titleRole(s) of Leader protein of Saffold virus
authorShimizu, Ai ; Himeda, Toshiki ; Okuwa, Takako ; Muraki, Yasushi ; Ohara, Yoshiro
creationdate20141000
facets
frbrgroupid3390400266345418642
frbrtype5
creationdate2014
topic
0Anti‐Interferon Response
1Leader Protein
2Saffold Virus
collectionWiley Online Library
prefilterarticles
rsrctypearticles
creatorcontrib
0Shimizu, Ai
1Himeda, Toshiki
2Okuwa, Takako
3Muraki, Yasushi
4Ohara, Yoshiro
jtitleClinical and Experimental Neuroimmunology
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Shimizu
1Himeda
2Okuwa
3Muraki
4Ohara
aufirst
0Ai
1Toshiki
2Takako
3Yasushi
4Yoshiro
au
0Shimizu, Ai
1Himeda, Toshiki
2Okuwa, Takako
3Muraki, Yasushi
4Ohara, Yoshiro
atitleRole(s) of Leader protein of Saffold virus
jtitleClinical and Experimental Neuroimmunology
risdate201410
volume5
issue3
spage362
epage366
issn1759-1961
eissn1759-1961
genrearticle
ristypeJOUR
doi10.1111/cen3.12109
pages362-366
date2014-10