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The importance of environment on respiratory genotype/phenotype relationships in the Inuit

To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1398-9995.2009.02145.x Keywords: asthma genetics; gene-environment interaction; lung function and rhinitis Abstract: To cite this article: Candelaria PV, Backer V, Khoo S-K, Bizzintino JA, Hayden CM... Full description

Journal Title: Allergy February 2010, Vol.65(2), pp.229-237
Main Author: Candelaria, P. V.
Other Authors: Backer, V. , Khoo, S. ‐K. , Bizzintino, J. A. , Hayden, C. M. , Baynam, G. , Laing, I. A. , Zhang, G. , Porsbjerg, C. , Goldblatt, J. , Le Souëf, P. N.
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ID: ISSN: 0105-4538 ; E-ISSN: 1398-9995 ; DOI: 10.1111/j.1398-9995.2009.02145.x
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recordid: wj10.1111/j.1398-9995.2009.02145.x
title: The importance of environment on respiratory genotype/phenotype relationships in the Inuit
format: Article
creator:
  • Candelaria, P. V.
  • Backer, V.
  • Khoo, S. ‐K.
  • Bizzintino, J. A.
  • Hayden, C. M.
  • Baynam, G.
  • Laing, I. A.
  • Zhang, G.
  • Porsbjerg, C.
  • Goldblatt, J.
  • Le Souëf, P. N.
subjects:
  • Asthma Genetics
  • Gene–Environment Interaction
  • Lung Function And Rhinitis
ispartof: Allergy, February 2010, Vol.65(2), pp.229-237
description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1398-9995.2009.02145.x Keywords: asthma genetics; gene-environment interaction; lung function and rhinitis Abstract: To cite this article: Candelaria PV, Backer V, Khoo S-K, Bizzintino JA, Hayden CM, Baynam G, Laing IA, Zhang G, Porsbjerg C, Goldblatt J, LeSouef PN, The Greenlandic Study Population Group. The importance of environment on respiratory genotype/phenotype relationships in the Inuit. Allergy 2010; 65: 229-237. Abstract Background: Genetic and environmental influences and their interactions are central to asthma pathogenesis. This study aimed to investigate the effects of different macro-environments on asthma genotype-phenotype associations in two geographically separated populations with common ancestry. Methods: To accomplish this, two unselected populations of Inuit were recruited, one living in Greenland (n = 618) and the other in Denmark (n = 739). Subjects were genotyped for CD14 C-159T, SCGB1A1 A38G, ADRB2 Arg16Gly and Gln27Glu. The resulting genetic data were analysed for relationships with asthma-related parameters including lung function, ever asthma, atopy, rhinitis and dermatitis. Results: The results showed contrasting magnitude and direction of genetic associations between the two geographically separate Inuit populations. In Greenland, the ADRB2 16Arg allele was associated with male-specific lower lung function, but in Denmark the same allele was associated with male-specific higher lung function. This allele was also associated with higher incidence of ever asthma in Denmark but not in Greenland. The SCGB1A1 38A allele was associated with lower rhinitis prevalence in Greenland but not in Denmark. Conclusions: These associations suggest that environment interacts with candidate asthma genes to modulate asthma pathogenesis in the Inuit. Author Affiliation: (1)School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia (2)Respiratory Research Unit, Department of Internal Medicine, Bispebjerg University Hospital, Copenhagen, Denmark (3)Divisions of Population Sciences & Genetics and Health, Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, WA, Australia (4)Genetic Services of Western Australia, Perth, WA, Australia (5)National Institute of Public Health, Department for Research in Greenland, Copenhagen, Denmark Article History: Accep
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identifier: ISSN: 0105-4538 ; E-ISSN: 1398-9995 ; DOI: 10.1111/j.1398-9995.2009.02145.x
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  • 0105-4538
  • 01054538
  • 1398-9995
  • 13989995
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titleThe importance of environment on respiratory genotype/phenotype relationships in the Inuit
creatorCandelaria, P. V. ; Backer, V. ; Khoo, S. ‐K. ; Bizzintino, J. A. ; Hayden, C. M. ; Baynam, G. ; Laing, I. A. ; Zhang, G. ; Porsbjerg, C. ; Goldblatt, J. ; Le Souëf, P. N.
ispartofAllergy, February 2010, Vol.65(2), pp.229-237
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descriptionTo authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1398-9995.2009.02145.x Keywords: asthma genetics; gene-environment interaction; lung function and rhinitis Abstract: To cite this article: Candelaria PV, Backer V, Khoo S-K, Bizzintino JA, Hayden CM, Baynam G, Laing IA, Zhang G, Porsbjerg C, Goldblatt J, LeSouef PN, The Greenlandic Study Population Group. The importance of environment on respiratory genotype/phenotype relationships in the Inuit. Allergy 2010; 65: 229-237. Abstract Background: Genetic and environmental influences and their interactions are central to asthma pathogenesis. This study aimed to investigate the effects of different macro-environments on asthma genotype-phenotype associations in two geographically separated populations with common ancestry. Methods: To accomplish this, two unselected populations of Inuit were recruited, one living in Greenland (n = 618) and the other in Denmark (n = 739). Subjects were genotyped for CD14 C-159T, SCGB1A1 A38G, ADRB2 Arg16Gly and Gln27Glu. The resulting genetic data were analysed for relationships with asthma-related parameters including lung function, ever asthma, atopy, rhinitis and dermatitis. Results: The results showed contrasting magnitude and direction of genetic associations between the two geographically separate Inuit populations. In Greenland, the ADRB2 16Arg allele was associated with male-specific lower lung function, but in Denmark the same allele was associated with male-specific higher lung function. This allele was also associated with higher incidence of ever asthma in Denmark but not in Greenland. The SCGB1A1 38A allele was associated with lower rhinitis prevalence in Greenland but not in Denmark. Conclusions: These associations suggest that environment interacts with candidate asthma genes to modulate asthma pathogenesis in the Inuit. Author Affiliation: (1)School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia (2)Respiratory Research Unit, Department of Internal Medicine, Bispebjerg University Hospital, Copenhagen, Denmark (3)Divisions of Population Sciences & Genetics and Health, Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, WA, Australia (4)Genetic Services of Western Australia, Perth, WA, Australia (5)National Institute of Public Health, Department for Research in Greenland, Copenhagen, Denmark Article History: Accepted for publication 9 June 2009 Article note: Pierre Candelaria, School of Paediatrics and Child Health, University of Western Australia, GPO Box D184, Perth, 6001 WA, Australia.
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