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Hyperforin promotes mitochondrial function and development of oligodendrocytes

To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1471-4159.2011.07433.x Keywords: development; hyperforin; mitochondrial function; oligodendrocyte; St. John's wort Abstract: J. Neurochem. (2011) 119, 555-568. Abstract St. John's wort has been foun... Full description

Journal Title: Journal of Neurochemistry November 2011, Vol.119(3), pp.555-568
Main Author: Wang, Yanlin
Other Authors: Zhang, Yanbo , He, Jue , Zhang, Handi , Xiao, Lan , Nazarali, Adil , Zhang, Zhijun , Zhang, Dai , Tan, Qingrong , Kong, Jiming , Li, Xin‐Min
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ID: ISSN: 0022-3042 ; E-ISSN: 1471-4159 ; DOI: 10.1111/j.1471-4159.2011.07433.x
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recordid: wj10.1111/j.1471-4159.2011.07433.x
title: Hyperforin promotes mitochondrial function and development of oligodendrocytes
format: Article
creator:
  • Wang, Yanlin
  • Zhang, Yanbo
  • He, Jue
  • Zhang, Handi
  • Xiao, Lan
  • Nazarali, Adil
  • Zhang, Zhijun
  • Zhang, Dai
  • Tan, Qingrong
  • Kong, Jiming
  • Li, Xin‐Min
subjects:
  • Development
  • Hyperforin
  • Mitochondrial Function
  • Oligodendrocyte
  • St. John’s Wort
ispartof: Journal of Neurochemistry, November 2011, Vol.119(3), pp.555-568
description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1471-4159.2011.07433.x Keywords: development; hyperforin; mitochondrial function; oligodendrocyte; St. John's wort Abstract: J. Neurochem. (2011) 119, 555-568. Abstract St. John's wort has been found to be an effective and safe herbal treatment for depression in several clinical trials. However, the underlying mechanism of its therapeutic effects is unclear. Recent studies show that the loss and malfunction of oligodendrocytes are closely related to the neuropathological changes in depression, which can be reversed by antidepressant treatment. In this study, we evaluated the effects of hyperforin, a major active component of St. John's wort, on the proliferation, development and mitochondrial function of oligodendrocytes. The study results revealed that hyperforin promotes maturation of oligodendrocytes and increases mitochondrial function without affecting proliferation of an oligodendrocyte progenitor cell line and neural stem/progenitor cells. Hyperforin also prevented mitochondrial toxin-induced cytotoxicity in an oligodendrocyte progenitor cell line. These findings suggest that hyperforin may stimulate the development and function of oligodendrocytes, which could be a mechanism of its effect in depression. Future in vitro and in vivo studies are required to further characterize the mechanisms of hyperforin. Author Affiliation: (*)Department of Psychiatry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada ([dagger])Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada ([double dagger])Department of Histology and Embryology, Third Military Medical University, Chongqing, China (s.)Division of Pharmacy, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada ([paragraph])Department of Neuropsychiatry, Affiliated ZhongDa Hospital Southeast University, Nanjing, China (**)Institute of Mental Health, Peking University, Beijing, China ([dagger][dagger])Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, China ([double dagger][double dagger])Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada Article History: Received April 11, 2011; revised manuscript received August 3, 2011; accepted August 15, 2011. Article note: Address correspondence and reprint requests to Xin-Min Li, Department of Psychiatry, Faculty of Me
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identifier: ISSN: 0022-3042 ; E-ISSN: 1471-4159 ; DOI: 10.1111/j.1471-4159.2011.07433.x
fulltext: fulltext
issn:
  • 0022-3042
  • 00223042
  • 1471-4159
  • 14714159
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descriptionTo authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1471-4159.2011.07433.x Keywords: development; hyperforin; mitochondrial function; oligodendrocyte; St. John's wort Abstract: J. Neurochem. (2011) 119, 555-568. Abstract St. John's wort has been found to be an effective and safe herbal treatment for depression in several clinical trials. However, the underlying mechanism of its therapeutic effects is unclear. Recent studies show that the loss and malfunction of oligodendrocytes are closely related to the neuropathological changes in depression, which can be reversed by antidepressant treatment. In this study, we evaluated the effects of hyperforin, a major active component of St. John's wort, on the proliferation, development and mitochondrial function of oligodendrocytes. The study results revealed that hyperforin promotes maturation of oligodendrocytes and increases mitochondrial function without affecting proliferation of an oligodendrocyte progenitor cell line and neural stem/progenitor cells. Hyperforin also prevented mitochondrial toxin-induced cytotoxicity in an oligodendrocyte progenitor cell line. These findings suggest that hyperforin may stimulate the development and function of oligodendrocytes, which could be a mechanism of its effect in depression. Future in vitro and in vivo studies are required to further characterize the mechanisms of hyperforin. Author Affiliation: (*)Department of Psychiatry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada ([dagger])Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada ([double dagger])Department of Histology and Embryology, Third Military Medical University, Chongqing, China (s.)Division of Pharmacy, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada ([paragraph])Department of Neuropsychiatry, Affiliated ZhongDa Hospital Southeast University, Nanjing, China (**)Institute of Mental Health, Peking University, Beijing, China ([dagger][dagger])Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, China ([double dagger][double dagger])Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada Article History: Received April 11, 2011; revised manuscript received August 3, 2011; accepted August 15, 2011. Article note: Address correspondence and reprint requests to Xin-Min Li, Department of Psychiatry, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada. E-mail: xinmin_li@umanitoba.ca; and Jiming Kong, Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada. E-mail: kongj@cc.umanitoba.ca
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