schliessen

Filtern

 

Bibliotheken

Aspergillus bronchitis without significant immunocompromise

bronchitis is poorly understood and described. We extracted clinical data from more than 400 referred patients with persistent chest symptoms who did not fulfill criteria for allergic, chronic, or invasive aspergillosis. Symptomatic patients with a positive culture or real‐time PCR for spp. were rev... Full description

Journal Title: Annals of the New York Academy of Sciences December 2012, Vol.12721(1), pp.73-85
Main Author: Chrdle, Ales
Other Authors: Mustakim, Sahlawati , Bright‐Thomas, Rowland J. , Baxter, Caroline G. , Felton, Timothy , Denning, David W.
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0077-8923 ; E-ISSN: 1749-6632 ; DOI: 10.1111/j.1749-6632.2012.06816.x
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: wj10.1111/j.1749-6632.2012.06816.x
title: Aspergillus bronchitis without significant immunocompromise
format: Article
creator:
  • Chrdle, Ales
  • Mustakim, Sahlawati
  • Bright‐Thomas, Rowland J.
  • Baxter, Caroline G.
  • Felton, Timothy
  • Denning, David W.
subjects:
  • Mannose Binding Lectin
  • Fumigatus
  • Niger
  • Precipitins
  • Bronchiectasis
  • Aspergillary
ispartof: Annals of the New York Academy of Sciences, December 2012, Vol.12721(1), pp.73-85
description: bronchitis is poorly understood and described. We extracted clinical data from more than 400 referred patients with persistent chest symptoms who did not fulfill criteria for allergic, chronic, or invasive aspergillosis. Symptomatic patients with a positive culture or real‐time PCR for spp. were reviewed. Seventeen patients fulfilled the selected criteria. Fourteen were women, with a mean age of 57 years (range 39–76). Sixteen of the patients had productive cough, eight had voluminous tenacious sputum, and seven had recurrent chest infections. Eight patients had Medical Research Council dyspnea scores of 4–5; 12 had bronchiectasis; and 13 patients grew , 3 and 1 . Twelve of the 17 patients (71%) had elevated IgG (47–137 mg/L, mean 89.2) and 5 (29%) had elevated precipitins. Six of 12 (50%) had a major response to antifungal therapy and five of 12 (42%) patients relapsed, requiring long‐term therapy. bronchitis is a discrete clinical entity in patients with structural lung disease but who are not significantly immunocompromised. It is distinct from asymptomatic fungal colonization and other forms of aspergillosis, and may respond to antifungal therapy.
language:
source:
identifier: ISSN: 0077-8923 ; E-ISSN: 1749-6632 ; DOI: 10.1111/j.1749-6632.2012.06816.x
fulltext: fulltext
issn:
  • 0077-8923
  • 00778923
  • 1749-6632
  • 17496632
url: Link


@attributes
ID599920206
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1111/j.1749-6632.2012.06816.x
sourceidwj
recordidTN_wj10.1111/j.1749-6632.2012.06816.x
sourcesystemOther
pqid1769992015
display
typearticle
titleAspergillus bronchitis without significant immunocompromise
creatorChrdle, Ales ; Mustakim, Sahlawati ; Bright‐Thomas, Rowland J. ; Baxter, Caroline G. ; Felton, Timothy ; Denning, David W.
ispartofAnnals of the New York Academy of Sciences, December 2012, Vol.12721(1), pp.73-85
identifier
subjectMannose Binding Lectin ; Fumigatus ; Niger ; Precipitins ; Bronchiectasis ; Aspergillary
descriptionbronchitis is poorly understood and described. We extracted clinical data from more than 400 referred patients with persistent chest symptoms who did not fulfill criteria for allergic, chronic, or invasive aspergillosis. Symptomatic patients with a positive culture or real‐time PCR for spp. were reviewed. Seventeen patients fulfilled the selected criteria. Fourteen were women, with a mean age of 57 years (range 39–76). Sixteen of the patients had productive cough, eight had voluminous tenacious sputum, and seven had recurrent chest infections. Eight patients had Medical Research Council dyspnea scores of 4–5; 12 had bronchiectasis; and 13 patients grew , 3 and 1 . Twelve of the 17 patients (71%) had elevated IgG (47–137 mg/L, mean 89.2) and 5 (29%) had elevated precipitins. Six of 12 (50%) had a major response to antifungal therapy and five of 12 (42%) patients relapsed, requiring long‐term therapy. bronchitis is a discrete clinical entity in patients with structural lung disease but who are not significantly immunocompromised. It is distinct from asymptomatic fungal colonization and other forms of aspergillosis, and may respond to antifungal therapy.
source
version5
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Chrdle, Ales
1Mustakim, Sahlawati
2Bright‐Thomas, Rowland J.
3Baxter, Caroline G.
4Felton, Timothy
5Denning, David W.
titleAspergillus bronchitis without significant immunocompromise
descriptionbronchitis is poorly understood and described. We extracted clinical data from more than 400 referred patients with persistent chest symptoms who did not fulfill criteria for allergic, chronic, or invasive aspergillosis. Symptomatic patients with a positive culture or real‐time PCR for spp. were reviewed. Seventeen patients fulfilled the selected criteria. Fourteen were women, with a mean age of 57 years (range 39–76). Sixteen of the patients had productive cough, eight had voluminous tenacious sputum, and seven had recurrent chest infections. Eight patients had Medical Research Council dyspnea scores of 4–5; 12 had bronchiectasis; and 13 patients grew , 3 and 1 . Twelve of the 17 patients (71%) had elevated IgG (47–137 mg/L, mean 89.2) and 5 (29%) had elevated precipitins. Six of 12 (50%) had a major response to antifungal therapy and five of 12 (42%) patients relapsed, requiring long‐term therapy. bronchitis is a discrete clinical entity in patients with structural lung disease but who are not significantly immunocompromised. It is distinct from asymptomatic fungal colonization and other forms of aspergillosis, and may respond to antifungal therapy.
subject
0Mannose Binding Lectin
1Fumigatus
2Niger
3Precipitins
4Bronchiectasis
5Aspergillary
general
0Blackwell Publishing Inc
110.1111/j.1749-6632.2012.06816.x
2Wiley Online Library
sourceidwj
recordidwj10.1111/j.1749-6632.2012.06816.x
issn
00077-8923
100778923
21749-6632
317496632
rsrctypearticle
creationdate2012
addtitleAnnals of the New York Academy of Sciences
searchscope
0wj
1wiley
scope
0wj
1wiley
lsr30VSR-Enriched:[vol, pqid, pages]
sort
titleAspergillus bronchitis without significant immunocompromise
authorChrdle, Ales ; Mustakim, Sahlawati ; Bright‐Thomas, Rowland J. ; Baxter, Caroline G. ; Felton, Timothy ; Denning, David W.
creationdate20121200
facets
frbrgroupid7606925308814415323
frbrtype5
creationdate2012
topic
0Mannose Binding Lectin
1Fumigatus
2Niger
3Precipitins
4Bronchiectasis
5Aspergillary
collectionWiley Online Library
prefilterarticles
rsrctypearticles
creatorcontrib
0Chrdle, Ales
1Mustakim, Sahlawati
2Bright‐Thomas, Rowland J.
3Baxter, Caroline G.
4Felton, Timothy
5Denning, David W.
jtitleAnnals of the New York Academy of Sciences
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Chrdle
1Mustakim
2Bright‐Thomas
3Baxter
4Felton
5Denning
aufirst
0Ales
1Sahlawati
2Rowland J.
3Caroline G.
4Timothy
5David W.
au
0Chrdle, Ales
1Mustakim, Sahlawati
2Bright‐Thomas, Rowland J.
3Baxter, Caroline G.
4Felton, Timothy
5Denning, David W.
atitleAspergillus bronchitis without significant immunocompromise
jtitleAnnals of the New York Academy of Sciences
risdate201212
volume1272
issue1
spage73
epage85
issn0077-8923
eissn1749-6632
genrearticle
ristypeJOUR
abstractbronchitis is poorly understood and described. We extracted clinical data from more than 400 referred patients with persistent chest symptoms who did not fulfill criteria for allergic, chronic, or invasive aspergillosis. Symptomatic patients with a positive culture or real‐time PCR for spp. were reviewed. Seventeen patients fulfilled the selected criteria. Fourteen were women, with a mean age of 57 years (range 39–76). Sixteen of the patients had productive cough, eight had voluminous tenacious sputum, and seven had recurrent chest infections. Eight patients had Medical Research Council dyspnea scores of 4–5; 12 had bronchiectasis; and 13 patients grew , 3 and 1 . Twelve of the 17 patients (71%) had elevated IgG (47–137 mg/L, mean 89.2) and 5 (29%) had elevated precipitins. Six of 12 (50%) had a major response to antifungal therapy and five of 12 (42%) patients relapsed, requiring long‐term therapy. bronchitis is a discrete clinical entity in patients with structural lung disease but who are not significantly immunocompromised. It is distinct from asymptomatic fungal colonization and other forms of aspergillosis, and may respond to antifungal therapy.
copMalden, USA
pubBlackwell Publishing Inc
doi10.1111/j.1749-6632.2012.06816.x
pages73-85
date2012-12