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Discovery and characterization of two novel CB1 receptor splice variants with modified N‐termini in mouse

Two novel introns in the mouse CB1 receptor were identified. Splicing leads to variants with shortened N‐terminal tails, but leaves the highly conserved N‐terminal loop which contributes to the ligand‐binding pocket intact. Differing from the variants identified in human and having a much lower expr... Full description

Journal Title: Journal of Neurochemistry August 2017, Vol.142(4), pp.521-533
Main Author: Ruehle, Sabine
Other Authors: Wager‐Miller, James , Straiker, Alex , Farnsworth, Jill , Murphy, Michelle N. , Loch, Sebastian , Monory, Krisztina , Mackie, Ken , Lutz, Beat
Format: Electronic Article Electronic Article
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ID: ISSN: 0022-3042 ; E-ISSN: 1471-4159 ; DOI: 10.1111/jnc.14099
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recordid: wj10.1111/jnc.14099
title: Discovery and characterization of two novel CB1 receptor splice variants with modified N‐termini in mouse
format: Article
creator:
  • Ruehle, Sabine
  • Wager‐Miller, James
  • Straiker, Alex
  • Farnsworth, Jill
  • Murphy, Michelle N.
  • Loch, Sebastian
  • Monory, Krisztina
  • Mackie, Ken
  • Lutz, Beat
subjects:
  • Alternative Splicing
  • Brain
  • Cannabinoid
  • Cb 1
  • Mice
  • Receptor
ispartof: Journal of Neurochemistry, August 2017, Vol.142(4), pp.521-533
description: Two novel introns in the mouse CB1 receptor were identified. Splicing leads to variants with shortened N‐terminal tails, but leaves the highly conserved N‐terminal loop which contributes to the ligand‐binding pocket intact. Differing from the variants identified in human and having a much lower expression, this might help to explain some of the differences seen between human and mouse endocannabinoid systems.
language:
source:
identifier: ISSN: 0022-3042 ; E-ISSN: 1471-4159 ; DOI: 10.1111/jnc.14099
fulltext: fulltext
issn:
  • 0022-3042
  • 00223042
  • 1471-4159
  • 14714159
url: Link


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titleDiscovery and characterization of two novel CB1 receptor splice variants with modified N‐termini in mouse
creatorRuehle, Sabine ; Wager‐Miller, James ; Straiker, Alex ; Farnsworth, Jill ; Murphy, Michelle N. ; Loch, Sebastian ; Monory, Krisztina ; Mackie, Ken ; Lutz, Beat
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subjectAlternative Splicing ; Brain ; Cannabinoid ; Cb 1 ; Mice ; Receptor
descriptionTwo novel introns in the mouse CB1 receptor were identified. Splicing leads to variants with shortened N‐terminal tails, but leaves the highly conserved N‐terminal loop which contributes to the ligand‐binding pocket intact. Differing from the variants identified in human and having a much lower expression, this might help to explain some of the differences seen between human and mouse endocannabinoid systems.
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titleDiscovery and characterization of two novel CB1 receptor splice variants with modified N‐termini in mouse
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titleDiscovery and characterization of two novel CB1 receptor splice variants with modified N‐termini in mouse
authorRuehle, Sabine ; Wager‐Miller, James ; Straiker, Alex ; Farnsworth, Jill ; Murphy, Michelle N. ; Loch, Sebastian ; Monory, Krisztina ; Mackie, Ken ; Lutz, Beat
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abstractTwo novel introns in the mouse CB1 receptor were identified. Splicing leads to variants with shortened N‐terminal tails, but leaves the highly conserved N‐terminal loop which contributes to the ligand‐binding pocket intact. Differing from the variants identified in human and having a much lower expression, this might help to explain some of the differences seen between human and mouse endocannabinoid systems.
doi10.1111/jnc.14099
pages521-533
orcididhttp://orcid.org/0000-0003-0430-2367
date2017-08