schliessen

Filtern

 

Bibliotheken

Melatonin in macrophage biology: Current understanding and future perspectives

Melatonin is a ubiquitous hormone found in various organisms and highly affects the function of immune cells. In this review, we summarize the current understanding of the significance of melatonin in macrophage biology and the beneficial effects of melatonin in macrophage‐associated diseases. Enzym... Full description

Journal Title: Journal of Pineal Research March 2019, Vol.66(2), pp.n/a-n/a
Main Author: Xia, Yaoyao
Other Authors: Chen, Siyuan , Zeng, Sijing , Zhao, Yuanyuan , Zhu, Congrui , Deng, Baichuan , Zhu, Guoqiang , Yin, Yulong , Wang, Wence , Hardeland, Rüdiger , Ren, Wenkai
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0742-3098 ; E-ISSN: 1600-079X ; DOI: 10.1111/jpi.12547
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: wj10.1111/jpi.12547
title: Melatonin in macrophage biology: Current understanding and future perspectives
format: Article
creator:
  • Xia, Yaoyao
  • Chen, Siyuan
  • Zeng, Sijing
  • Zhao, Yuanyuan
  • Zhu, Congrui
  • Deng, Baichuan
  • Zhu, Guoqiang
  • Yin, Yulong
  • Wang, Wence
  • Hardeland, Rüdiger
  • Ren, Wenkai
subjects:
  • Macrophage
  • Melatonin
  • Metabolism
  • Microrna
  • Mitochondria
ispartof: Journal of Pineal Research, March 2019, Vol.66(2), pp.n/a-n/a
description: Melatonin is a ubiquitous hormone found in various organisms and highly affects the function of immune cells. In this review, we summarize the current understanding of the significance of melatonin in macrophage biology and the beneficial effects of melatonin in macrophage‐associated diseases. Enzymes associated with synthesis of melatonin, as well as membrane receptors for melatonin, are found in macrophages. Indeed, melatonin influences the phenotype polarization of macrophages. Mechanistically, the roles of melatonin in macrophages are related to several cellular signaling pathways, such as NF‐κB, STATs, and NLRP3/caspase‐1. Notably, miRNAs (eg, miR‐155/‐34a/‐23a), cellular metabolic pathways (eg, α‐KG, HIF‐1α, and ROS), and mitochondrial dynamics and mitophagy are also involved. Thus, melatonin modulates the development and progression of various macrophage‐associated diseases, such as cancer and rheumatoid arthritis. This review provides a better understanding about the importance of melatonin in macrophage biology and macrophage‐associated diseases.
language:
source:
identifier: ISSN: 0742-3098 ; E-ISSN: 1600-079X ; DOI: 10.1111/jpi.12547
fulltext: fulltext
issn:
  • 0742-3098
  • 07423098
  • 1600-079X
  • 1600079X
url: Link


@attributes
ID634839716
RANK0.06999999
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1111/jpi.12547
sourceidwj
recordidTN_wj10.1111/jpi.12547
sourcesystemOther
pqid2162493353
galeid572533278
display
typearticle
titleMelatonin in macrophage biology: Current understanding and future perspectives
creatorXia, Yaoyao ; Chen, Siyuan ; Zeng, Sijing ; Zhao, Yuanyuan ; Zhu, Congrui ; Deng, Baichuan ; Zhu, Guoqiang ; Yin, Yulong ; Wang, Wence ; Hardeland, Rüdiger ; Ren, Wenkai
ispartofJournal of Pineal Research, March 2019, Vol.66(2), pp.n/a-n/a
identifier
subjectMacrophage ; Melatonin ; Metabolism ; Microrna ; Mitochondria
descriptionMelatonin is a ubiquitous hormone found in various organisms and highly affects the function of immune cells. In this review, we summarize the current understanding of the significance of melatonin in macrophage biology and the beneficial effects of melatonin in macrophage‐associated diseases. Enzymes associated with synthesis of melatonin, as well as membrane receptors for melatonin, are found in macrophages. Indeed, melatonin influences the phenotype polarization of macrophages. Mechanistically, the roles of melatonin in macrophages are related to several cellular signaling pathways, such as NF‐κB, STATs, and NLRP3/caspase‐1. Notably, miRNAs (eg, miR‐155/‐34a/‐23a), cellular metabolic pathways (eg, α‐KG, HIF‐1α, and ROS), and mitochondrial dynamics and mitophagy are also involved. Thus, melatonin modulates the development and progression of various macrophage‐associated diseases, such as cancer and rheumatoid arthritis. This review provides a better understanding about the importance of melatonin in macrophage biology and macrophage‐associated diseases.
source
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Xia, Yaoyao
1Chen, Siyuan
2Zeng, Sijing
3Zhao, Yuanyuan
4Zhu, Congrui
5Deng, Baichuan
6Zhu, Guoqiang
7Yin, Yulong
8Wang, Wence
9Hardeland, Rüdiger
10Ren, Wenkai
titleMelatonin in macrophage biology: Current understanding and future perspectives
descriptionMelatonin is a ubiquitous hormone found in various organisms and highly affects the function of immune cells. In this review, we summarize the current understanding of the significance of melatonin in macrophage biology and the beneficial effects of melatonin in macrophage‐associated diseases. Enzymes associated with synthesis of melatonin, as well as membrane receptors for melatonin, are found in macrophages. Indeed, melatonin influences the phenotype polarization of macrophages. Mechanistically, the roles of melatonin in macrophages are related to several cellular signaling pathways, such as NF‐κB, STATs, and NLRP3/caspase‐1. Notably, miRNAs (eg, miR‐155/‐34a/‐23a), cellular metabolic pathways (eg, α‐KG, HIF‐1α, and ROS), and mitochondrial dynamics and mitophagy are also involved. Thus, melatonin modulates the development and progression of various macrophage‐associated diseases, such as cancer and rheumatoid arthritis. This review provides a better understanding about the importance of melatonin in macrophage biology and macrophage‐associated diseases.
subject
0Macrophage
1Melatonin
2Metabolism
3Microrna
4Mitochondria
general
010.1111/jpi.12547
1Wiley Online Library
sourceidwj
recordidwj10.1111/jpi.12547
issn
00742-3098
107423098
21600-079X
31600079X
rsrctypearticle
creationdate2019
addtitle
0Journal of Pineal Research
1J Pineal Res
searchscope
0wj
1wiley
scope
0wj
1wiley
lsr30VSR-Enriched:[pqid, pages, galeid, orcidid]
sort
titleMelatonin in macrophage biology: Current understanding and future perspectives
authorXia, Yaoyao ; Chen, Siyuan ; Zeng, Sijing ; Zhao, Yuanyuan ; Zhu, Congrui ; Deng, Baichuan ; Zhu, Guoqiang ; Yin, Yulong ; Wang, Wence ; Hardeland, Rüdiger ; Ren, Wenkai
creationdate20190300
facets
frbrgroupid5676999209785012771
frbrtype5
newrecords20190213
creationdate2019
topic
0Macrophage
1Melatonin
2Metabolism
3Microrna
4Mitochondria
collectionWiley Online Library
prefilterarticles
rsrctypearticles
creatorcontrib
0Xia, Yaoyao
1Chen, Siyuan
2Zeng, Sijing
3Zhao, Yuanyuan
4Zhu, Congrui
5Deng, Baichuan
6Zhu, Guoqiang
7Yin, Yulong
8Wang, Wence
9Hardeland, Rüdiger
10Ren, Wenkai
jtitleJournal of Pineal Research
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Xia
1Chen
2Zeng
3Zhao
4Zhu
5Deng
6Yin
7Wang
8Hardeland
9Ren
aufirst
0Yaoyao
1Siyuan
2Sijing
3Yuanyuan
4Congrui
5Baichuan
6Guoqiang
7Yulong
8Wence
9Rüdiger
10Wenkai
au
0Xia, Yaoyao
1Chen, Siyuan
2Zeng, Sijing
3Zhao, Yuanyuan
4Zhu, Congrui
5Deng, Baichuan
6Zhu, Guoqiang
7Yin, Yulong
8Wang, Wence
9Hardeland, Rüdiger
10Ren, Wenkai
atitleMelatonin in macrophage biology: Current understanding and future perspectives
jtitleJournal of Pineal Research
risdate201903
volume66
issue2
spagen/a
epagen/a
issn0742-3098
eissn1600-079X
genrearticle
ristypeJOUR
abstractMelatonin is a ubiquitous hormone found in various organisms and highly affects the function of immune cells. In this review, we summarize the current understanding of the significance of melatonin in macrophage biology and the beneficial effects of melatonin in macrophage‐associated diseases. Enzymes associated with synthesis of melatonin, as well as membrane receptors for melatonin, are found in macrophages. Indeed, melatonin influences the phenotype polarization of macrophages. Mechanistically, the roles of melatonin in macrophages are related to several cellular signaling pathways, such as NF‐κB, STATs, and NLRP3/caspase‐1. Notably, miRNAs (eg, miR‐155/‐34a/‐23a), cellular metabolic pathways (eg, α‐KG, HIF‐1α, and ROS), and mitochondrial dynamics and mitophagy are also involved. Thus, melatonin modulates the development and progression of various macrophage‐associated diseases, such as cancer and rheumatoid arthritis. This review provides a better understanding about the importance of melatonin in macrophage biology and macrophage‐associated diseases.
doi10.1111/jpi.12547
pagese12547
orcidid0000-0003-0178-6378
date2019-03