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Sticking out of the crowd: the molecular identity and development of cholecystokinin‐containing basket cells

Certain essential cognitive processes require the precise temporal interplay between glutamatergic (excitatory) pyramidal cells and γ‐aminobutyric acid (GABA)‐releasing inhibitory interneurons in the hippocampus. Basket cells, the main class of interneurons, target pyramidal cell somata and proximal... Full description

Journal Title: Journal of Physiology 15 February 2012, Vol.590(4), pp.703-714
Main Author: Keimpema, Erik
Other Authors: Straiker, Alex , Mackie, Ken , Harkany, Tibor , Hjerling‐Leffler, Jens
Format: Electronic Article Electronic Article
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ID: ISSN: 0022-3751 ; E-ISSN: 1469-7793 ; DOI: 10.1113/jphysiol.2011.224386
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recordid: wj10.1113/jphysiol.2011.224386
title: Sticking out of the crowd: the molecular identity and development of cholecystokinin‐containing basket cells
format: Article
creator:
  • Keimpema, Erik
  • Straiker, Alex
  • Mackie, Ken
  • Harkany, Tibor
  • Hjerling‐Leffler, Jens
subjects:
  • Nervous System Diseases
  • Neurosciences
  • Universities And Colleges
  • Gaba
  • Schizophrenia
ispartof: Journal of Physiology, 15 February 2012, Vol.590(4), pp.703-714
description: Certain essential cognitive processes require the precise temporal interplay between glutamatergic (excitatory) pyramidal cells and γ‐aminobutyric acid (GABA)‐releasing inhibitory interneurons in the hippocampus. Basket cells, the main class of interneurons, target pyramidal cell somata and proximal dendrites and thus are poised to modify network oscillations. Though only present in limited numbers, the impaired development of basket cells can result in changes in the hippocampal circuitry leading to neurological disorders, such as schizophrenia. The diversity of the spatial origins, neurochemical make‐up, cytoarchitecture and network contributions amongst basket cells is a provocative example of interneuron heterogeneity in the hippocampus. This review discusses recent data concerned with the developmental trajectories of one subclass, the cholecystokinin‐containing basket cell, and emphasizes the significance of the short‐range intercellular guidance cues that have recently emerged to impact the formation and function of their inhibitory synapses.
language:
source:
identifier: ISSN: 0022-3751 ; E-ISSN: 1469-7793 ; DOI: 10.1113/jphysiol.2011.224386
fulltext: fulltext
issn:
  • 0022-3751
  • 00223751
  • 1469-7793
  • 14697793
url: Link


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titleSticking out of the crowd: the molecular identity and development of cholecystokinin‐containing basket cells
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descriptionCertain essential cognitive processes require the precise temporal interplay between glutamatergic (excitatory) pyramidal cells and γ‐aminobutyric acid (GABA)‐releasing inhibitory interneurons in the hippocampus. Basket cells, the main class of interneurons, target pyramidal cell somata and proximal dendrites and thus are poised to modify network oscillations. Though only present in limited numbers, the impaired development of basket cells can result in changes in the hippocampal circuitry leading to neurological disorders, such as schizophrenia. The diversity of the spatial origins, neurochemical make‐up, cytoarchitecture and network contributions amongst basket cells is a provocative example of interneuron heterogeneity in the hippocampus. This review discusses recent data concerned with the developmental trajectories of one subclass, the cholecystokinin‐containing basket cell, and emphasizes the significance of the short‐range intercellular guidance cues that have recently emerged to impact the formation and function of their inhibitory synapses.
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descriptionCertain essential cognitive processes require the precise temporal interplay between glutamatergic (excitatory) pyramidal cells and γ‐aminobutyric acid (GABA)‐releasing inhibitory interneurons in the hippocampus. Basket cells, the main class of interneurons, target pyramidal cell somata and proximal dendrites and thus are poised to modify network oscillations. Though only present in limited numbers, the impaired development of basket cells can result in changes in the hippocampal circuitry leading to neurological disorders, such as schizophrenia. The diversity of the spatial origins, neurochemical make‐up, cytoarchitecture and network contributions amongst basket cells is a provocative example of interneuron heterogeneity in the hippocampus. This review discusses recent data concerned with the developmental trajectories of one subclass, the cholecystokinin‐containing basket cell, and emphasizes the significance of the short‐range intercellular guidance cues that have recently emerged to impact the formation and function of their inhibitory synapses.
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abstractCertain essential cognitive processes require the precise temporal interplay between glutamatergic (excitatory) pyramidal cells and γ‐aminobutyric acid (GABA)‐releasing inhibitory interneurons in the hippocampus. Basket cells, the main class of interneurons, target pyramidal cell somata and proximal dendrites and thus are poised to modify network oscillations. Though only present in limited numbers, the impaired development of basket cells can result in changes in the hippocampal circuitry leading to neurological disorders, such as schizophrenia. The diversity of the spatial origins, neurochemical make‐up, cytoarchitecture and network contributions amongst basket cells is a provocative example of interneuron heterogeneity in the hippocampus. This review discusses recent data concerned with the developmental trajectories of one subclass, the cholecystokinin‐containing basket cell, and emphasizes the significance of the short‐range intercellular guidance cues that have recently emerged to impact the formation and function of their inhibitory synapses.
copOxford, UK
pubBlackwell Publishing Ltd
doi10.1113/jphysiol.2011.224386
pages703-714
date2012-02-15