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Central NPY‐Y5 sub‐receptor partially functions as a mediator of NPY‐induced hypothermia and affords thermotolerance in heat‐exposed fasted chicks

Exposure of chicks to a high ambient temperature () has previously been shown to increase neuropeptide Y () expression in the brain. Furthermore, it was found that has anti‐stress functions in heat‐exposed fasted chicks. The aim of the study was to reveal the role of central administration of on the... Full description

Journal Title: Physiological Reports December 2017, Vol.5(23), pp.n/a-n/a
Main Author: Eltahan, Hatem M.
Other Authors: Bahry, Mohammad A. , Yang, Hui , Han, Guofeng , Nguyen, Linh T. N. , Ikeda, Hiromi , Ali, Mohamed N. , Amber, Khairy A. , Furuse, Mitsuhiro , Chowdhury, Vishwajit S.
Format: Electronic Article Electronic Article
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Hsp
Npy
ID: ISSN: 2051-817X ; E-ISSN: 2051-817X ; DOI: 10.14814/phy2.13511
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title: Central NPY‐Y5 sub‐receptor partially functions as a mediator of NPY‐induced hypothermia and affords thermotolerance in heat‐exposed fasted chicks
format: Article
creator:
  • Eltahan, Hatem M.
  • Bahry, Mohammad A.
  • Yang, Hui
  • Han, Guofeng
  • Nguyen, Linh T. N.
  • Ikeda, Hiromi
  • Ali, Mohamed N.
  • Amber, Khairy A.
  • Furuse, Mitsuhiro
  • Chowdhury, Vishwajit S.
subjects:
  • Fasted Chicks
  • Hsp
  • Npy Sub‐Receptors
  • Npy
  • Rectal Temperature
ispartof: Physiological Reports, December 2017, Vol.5(23), pp.n/a-n/a
description: Exposure of chicks to a high ambient temperature () has previously been shown to increase neuropeptide Y () expression in the brain. Furthermore, it was found that has anti‐stress functions in heat‐exposed fasted chicks. The aim of the study was to reveal the role of central administration of on thermotolerance ability and the induction of heat‐shock protein () and sub‐receptors (s) in fasted chicks with the contribution of plasma metabolite changes. Six‐ or seven‐day‐old chicks were centrally injected with 0 or 375 pmol of and exposed to either (35 ± 1°C) or control thermoneutral temperature (: 30 ± 1°C) for 60 min while fasted. reduced body temperature under both and . enhanced the brain expression of ‐70 and ‐90, as well as of s‐Y5, ‐Y6, and ‐Y7, but not ‐Y1, ‐Y2, and ‐Y4, under and . A coinjection of an ‐Y5 antagonist (71683) and (375 pmol) attenuated the ‐induced hypothermia. Furthermore, central decreased plasma glucose and triacylglycerol under and and kept plasma corticosterone and epinephrine lower under . increased plasma taurine and anserine concentrations. In conclusion, brain ‐Y5 partially afforded protective thermotolerance in heat‐exposed fasted chicks. The ‐mediated reduction in plasma glucose and stress hormone levels and the increase in free amino acids in plasma further suggest that might potentially play a role in minimizing heat stress in fasted chicks. Brain NPY sub‐receptor‐Y5 partially afforded protective thermotolerance in heat‐exposed fasted chicks. The NPY‐mediated reduction in plasma glucose and stress hormone levels and the increase in free amino acids in plasma further suggest that NPY might potentially play a role in minimizing heat stress in fasted chicks.
language:
source:
identifier: ISSN: 2051-817X ; E-ISSN: 2051-817X ; DOI: 10.14814/phy2.13511
fulltext: fulltext
issn:
  • 2051-817X
  • 2051817X
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titleCentral NPY‐Y5 sub‐receptor partially functions as a mediator of NPY‐induced hypothermia and affords thermotolerance in heat‐exposed fasted chicks
creatorEltahan, Hatem M. ; Bahry, Mohammad A. ; Yang, Hui ; Han, Guofeng ; Nguyen, Linh T. N. ; Ikeda, Hiromi ; Ali, Mohamed N. ; Amber, Khairy A. ; Furuse, Mitsuhiro ; Chowdhury, Vishwajit S.
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subjectFasted Chicks ; Hsp ; Npy Sub‐Receptors ; Npy ; Rectal Temperature
descriptionExposure of chicks to a high ambient temperature () has previously been shown to increase neuropeptide Y () expression in the brain. Furthermore, it was found that has anti‐stress functions in heat‐exposed fasted chicks. The aim of the study was to reveal the role of central administration of on thermotolerance ability and the induction of heat‐shock protein () and sub‐receptors (s) in fasted chicks with the contribution of plasma metabolite changes. Six‐ or seven‐day‐old chicks were centrally injected with 0 or 375 pmol of and exposed to either (35 ± 1°C) or control thermoneutral temperature (: 30 ± 1°C) for 60 min while fasted. reduced body temperature under both and . enhanced the brain expression of ‐70 and ‐90, as well as of s‐Y5, ‐Y6, and ‐Y7, but not ‐Y1, ‐Y2, and ‐Y4, under and . A coinjection of an ‐Y5 antagonist (71683) and (375 pmol) attenuated the ‐induced hypothermia. Furthermore, central decreased plasma glucose and triacylglycerol under and and kept plasma corticosterone and epinephrine lower under . increased plasma taurine and anserine concentrations. In conclusion, brain ‐Y5 partially afforded protective thermotolerance in heat‐exposed fasted chicks. The ‐mediated reduction in plasma glucose and stress hormone levels and the increase in free amino acids in plasma further suggest that might potentially play a role in minimizing heat stress in fasted chicks. Brain NPY sub‐receptor‐Y5 partially afforded protective thermotolerance in heat‐exposed fasted chicks. The NPY‐mediated reduction in plasma glucose and stress hormone levels and the increase in free amino acids in plasma further suggest that NPY might potentially play a role in minimizing heat stress in fasted chicks.
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titleCentral NPY‐Y5 sub‐receptor partially functions as a mediator of NPY‐induced hypothermia and affords thermotolerance in heat‐exposed fasted chicks
descriptionExposure of chicks to a high ambient temperature () has previously been shown to increase neuropeptide Y () expression in the brain. Furthermore, it was found that has anti‐stress functions in heat‐exposed fasted chicks. The aim of the study was to reveal the role of central administration of on thermotolerance ability and the induction of heat‐shock protein () and sub‐receptors (s) in fasted chicks with the contribution of plasma metabolite changes. Six‐ or seven‐day‐old chicks were centrally injected with 0 or 375 pmol of and exposed to either (35 ± 1°C) or control thermoneutral temperature (: 30 ± 1°C) for 60 min while fasted. reduced body temperature under both and . enhanced the brain expression of ‐70 and ‐90, as well as of s‐Y5, ‐Y6, and ‐Y7, but not ‐Y1, ‐Y2, and ‐Y4, under and . A coinjection of an ‐Y5 antagonist (71683) and (375 pmol) attenuated the ‐induced hypothermia. Furthermore, central decreased plasma glucose and triacylglycerol under and and kept plasma corticosterone and epinephrine lower under . increased plasma taurine and anserine concentrations. In conclusion, brain ‐Y5 partially afforded protective thermotolerance in heat‐exposed fasted chicks. The ‐mediated reduction in plasma glucose and stress hormone levels and the increase in free amino acids in plasma further suggest that might potentially play a role in minimizing heat stress in fasted chicks. Brain NPY sub‐receptor‐Y5 partially afforded protective thermotolerance in heat‐exposed fasted chicks. The NPY‐mediated reduction in plasma glucose and stress hormone levels and the increase in free amino acids in plasma further suggest that NPY might potentially play a role in minimizing heat stress in fasted chicks.
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titleCentral NPY‐Y5 sub‐receptor partially functions as a mediator of NPY‐induced hypothermia and affords thermotolerance in heat‐exposed fasted chicks
authorEltahan, Hatem M. ; Bahry, Mohammad A. ; Yang, Hui ; Han, Guofeng ; Nguyen, Linh T. N. ; Ikeda, Hiromi ; Ali, Mohamed N. ; Amber, Khairy A. ; Furuse, Mitsuhiro ; Chowdhury, Vishwajit S.
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abstractExposure of chicks to a high ambient temperature () has previously been shown to increase neuropeptide Y () expression in the brain. Furthermore, it was found that has anti‐stress functions in heat‐exposed fasted chicks. The aim of the study was to reveal the role of central administration of on thermotolerance ability and the induction of heat‐shock protein () and sub‐receptors (s) in fasted chicks with the contribution of plasma metabolite changes. Six‐ or seven‐day‐old chicks were centrally injected with 0 or 375 pmol of and exposed to either (35 ± 1°C) or control thermoneutral temperature (: 30 ± 1°C) for 60 min while fasted. reduced body temperature under both and . enhanced the brain expression of ‐70 and ‐90, as well as of s‐Y5, ‐Y6, and ‐Y7, but not ‐Y1, ‐Y2, and ‐Y4, under and . A coinjection of an ‐Y5 antagonist (71683) and (375 pmol) attenuated the ‐induced hypothermia. Furthermore, central decreased plasma glucose and triacylglycerol under and and kept plasma corticosterone and epinephrine lower under . increased plasma taurine and anserine concentrations. In conclusion, brain ‐Y5 partially afforded protective thermotolerance in heat‐exposed fasted chicks. The ‐mediated reduction in plasma glucose and stress hormone levels and the increase in free amino acids in plasma further suggest that might potentially play a role in minimizing heat stress in fasted chicks. Brain NPY sub‐receptor‐Y5 partially afforded protective thermotolerance in heat‐exposed fasted chicks. The NPY‐mediated reduction in plasma glucose and stress hormone levels and the increase in free amino acids in plasma further suggest that NPY might potentially play a role in minimizing heat stress in fasted chicks.
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