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Therapy of human ovarian carcinoma xenografts using doxorubicin encapsulated in sterically stabilized liposomes

This study compared the therapeutic effects of doxorubicin hydrochloride in saline and in sterically stabilized, long‐circulating liposomes composed of hydrogenated soy phosphatidylcholine/cholesterol/polyethylene glycol‐distearoyl‐phosphatidyl‐ethanolamine (Doxil). The drug formulations were inject... Full description

Journal Title: Cancer 15 December 1993, Vol.72(12), pp.3671-3675
Main Author: Vaage, Jan
Other Authors: Donovan, Dorothy , Mayhew, Eric , Abra, Robert , Huang, Anthony
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0008-543X ; E-ISSN: 1097-0142 ; DOI: 10.1002/1097-0142(19931215)72:12<3671::AID-CNCR2820721219>3.0.CO;2-U
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recordid: wjAID-CNCR2820721219>3.0.CO;2-U
title: Therapy of human ovarian carcinoma xenografts using doxorubicin encapsulated in sterically stabilized liposomes
format: Article
creator:
  • Vaage, Jan
  • Donovan, Dorothy
  • Mayhew, Eric
  • Abra, Robert
  • Huang, Anthony
subjects:
  • Liposomes
  • Doxorubicin
  • Therapy
  • Ovarian Carcinoma
ispartof: Cancer, 15 December 1993, Vol.72(12), pp.3671-3675
description: This study compared the therapeutic effects of doxorubicin hydrochloride in saline and in sterically stabilized, long‐circulating liposomes composed of hydrogenated soy phosphatidylcholine/cholesterol/polyethylene glycol‐distearoyl‐phosphatidyl‐ethanolamine (Doxil). The drug formulations were injected intravenously or intraperitoneally to treat the human ovarian carcinoma HEY, which was implanted subcutaneously or intraperitoneally into mature female Swiss nude mice. The long‐circulating liposome formulation was significantly more effective than was the free drug in inhibiting tumor growth and in producing cure. The liposome formulation was significantly less toxic than was the free drug. This is the first demonstration of the therapeutic effectiveness of doxorubicin in sterically stabilized liposomes against human tumor xenografts. The encapsulation of doxorubicin in long‐circulating liposomes significantly enhanced the therapeutic efficacy of the drug against a human ovarian carcinoma.
language: eng
source:
identifier: ISSN: 0008-543X ; E-ISSN: 1097-0142 ; DOI: 10.1002/1097-0142(19931215)72:12<3671::AID-CNCR2820721219>3.0.CO;2-U
fulltext: fulltext
issn:
  • 0008-543X
  • 0008543X
  • 1097-0142
  • 10970142
url: Link


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titleTherapy of human ovarian carcinoma xenografts using doxorubicin encapsulated in sterically stabilized liposomes
creatorVaage, Jan ; Donovan, Dorothy ; Mayhew, Eric ; Abra, Robert ; Huang, Anthony
ispartofCancer, 15 December 1993, Vol.72(12), pp.3671-3675
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subjectLiposomes ; Doxorubicin ; Therapy ; Ovarian Carcinoma
descriptionThis study compared the therapeutic effects of doxorubicin hydrochloride in saline and in sterically stabilized, long‐circulating liposomes composed of hydrogenated soy phosphatidylcholine/cholesterol/polyethylene glycol‐distearoyl‐phosphatidyl‐ethanolamine (Doxil). The drug formulations were injected intravenously or intraperitoneally to treat the human ovarian carcinoma HEY, which was implanted subcutaneously or intraperitoneally into mature female Swiss nude mice. The long‐circulating liposome formulation was significantly more effective than was the free drug in inhibiting tumor growth and in producing cure. The liposome formulation was significantly less toxic than was the free drug. This is the first demonstration of the therapeutic effectiveness of doxorubicin in sterically stabilized liposomes against human tumor xenografts. The encapsulation of doxorubicin in long‐circulating liposomes significantly enhanced the therapeutic efficacy of the drug against a human ovarian carcinoma.
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titleTherapy of human ovarian carcinoma xenografts using doxorubicin encapsulated in sterically stabilized liposomes
descriptionThis study compared the therapeutic effects of doxorubicin hydrochloride in saline and in sterically stabilized, long‐circulating liposomes composed of hydrogenated soy phosphatidylcholine/cholesterol/polyethylene glycol‐distearoyl‐phosphatidyl‐ethanolamine (Doxil). The drug formulations were injected intravenously or intraperitoneally to treat the human ovarian carcinoma HEY, which was implanted subcutaneously or intraperitoneally into mature female Swiss nude mice. The long‐circulating liposome formulation was significantly more effective than was the free drug in inhibiting tumor growth and in producing cure. The liposome formulation was significantly less toxic than was the free drug. This is the first demonstration of the therapeutic effectiveness of doxorubicin in sterically stabilized liposomes against human tumor xenografts. The encapsulation of doxorubicin in long‐circulating liposomes significantly enhanced the therapeutic efficacy of the drug against a human ovarian carcinoma.
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abstractThis study compared the therapeutic effects of doxorubicin hydrochloride in saline and in sterically stabilized, long‐circulating liposomes composed of hydrogenated soy phosphatidylcholine/cholesterol/polyethylene glycol‐distearoyl‐phosphatidyl‐ethanolamine (Doxil). The drug formulations were injected intravenously or intraperitoneally to treat the human ovarian carcinoma HEY, which was implanted subcutaneously or intraperitoneally into mature female Swiss nude mice. The long‐circulating liposome formulation was significantly more effective than was the free drug in inhibiting tumor growth and in producing cure. The liposome formulation was significantly less toxic than was the free drug. This is the first demonstration of the therapeutic effectiveness of doxorubicin in sterically stabilized liposomes against human tumor xenografts. The encapsulation of doxorubicin in long‐circulating liposomes significantly enhanced the therapeutic efficacy of the drug against a human ovarian carcinoma.
copNew York
pubWiley Subscription Services, Inc., A Wiley Company
doi10.1002/1097-0142(19931215)72:12<3671::AID-CNCR2820721219>3.0.CO;2-U
pages3671-3675
date1993-12-15